Associations of psychosocial stress with type 2 diabetes and glycaemic control among Ghanaians: The RODAM study

Felix P Chilunga; Pleun S Schwerzel; Karlijn A C Meeks; Erik Beune; Silver Bahendeka; Frank Mockenhaupt; Kerstin Klipstein-Grobusch; Charles Agyemang

doi:10.1111/dme.15006

Associations of psychosocial stress with type 2 diabetes and glycaemic control among Ghanaians: The RODAM study

Felix P Chilunga^*, Pleun S Schwerzel^*, Karlijn A C Meeks, Erik Beune, Silver Bahendeka, Frank Mockenhaupt, Kerstin Klipstein-Grobusch, Charles Agyemang

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

BACKGROUND: The extent to which psychosocial stress relates to type 2 diabetes among sub-Saharan Africans is not well understood. We assessed associations of psychosocial stresses with type 2 diabetes status and glycaemic control among Ghanaians.

METHODS: We used data from Research on Obesity and Diabetes among African Migrants (RODAM) study. We performed logistic and linear regression models to assess association of psychosocial stresses with type 2 diabetes and HbA1c respectively with adjustments for age, sex, education and other stresses. We also assessed moderation effects of migration status (migrant Ghanaians vs. non-migrant Ghanaians), age, sex and education by adding interaction terms in models.

RESULTS: Four thousand eight hundred and forty one Ghanaians were included with 44% resident in Ghana, 62% women, mean age of 46 years and 10% having type 2 diabetes. Psychosocial stress at home and at work were not associated with type 2 diabetes or HbA1c levels. Negative life events in past 12 months were negatively associated with type 2 diabetes (adjusted odds ratio = 0.93, 95% CI 0.87-0.99). Perceived discrimination was positively associated with type 2 diabetes (aOR = 1.01, 95% CI 1.004-1.03). Both associations were more pronounced in men. Perceived discrimination was also positively associated with HbA1c levels, especially among those with type 2 diabetes (adjusted β = 0.01, 95% CI 0.007-0.02).

CONCLUSIONS: Perceived discrimination and negative life events are associated with type 2 diabetes and glycaemic control among Ghanaians, especially in men. Further studies are needed to identify context-specific mechanisms underlying these associations.

Original language	English
Article number	e15006
Pages (from-to)	1-10
Journal	Diabetic Medicine
Volume	40
Issue number	1
DOIs	https://doi.org/10.1111/dme.15006
Publication status	Published - Jan 2023

Keywords

glycaemic control
psychosocial stress
sub-Saharan Africans; migration
type 2 diabetes

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Diabetic Medicine - 2022 - Chilunga - Associations of psychosocial stress with type 2 diabetes and glycaemic control amongFinal published version, 166 KBLicence: CC BY-NC-ND

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title = "Associations of psychosocial stress with type 2 diabetes and glycaemic control among Ghanaians: The RODAM study",

abstract = "BACKGROUND: The extent to which psychosocial stress relates to type 2 diabetes among sub-Saharan Africans is not well understood. We assessed associations of psychosocial stresses with type 2 diabetes status and glycaemic control among Ghanaians.METHODS: We used data from Research on Obesity and Diabetes among African Migrants (RODAM) study. We performed logistic and linear regression models to assess association of psychosocial stresses with type 2 diabetes and HbA1c respectively with adjustments for age, sex, education and other stresses. We also assessed moderation effects of migration status (migrant Ghanaians vs. non-migrant Ghanaians), age, sex and education by adding interaction terms in models.RESULTS: Four thousand eight hundred and forty one Ghanaians were included with 44% resident in Ghana, 62% women, mean age of 46 years and 10% having type 2 diabetes. Psychosocial stress at home and at work were not associated with type 2 diabetes or HbA1c levels. Negative life events in past 12 months were negatively associated with type 2 diabetes (adjusted odds ratio = 0.93, 95% CI 0.87-0.99). Perceived discrimination was positively associated with type 2 diabetes (aOR = 1.01, 95% CI 1.004-1.03). Both associations were more pronounced in men. Perceived discrimination was also positively associated with HbA1c levels, especially among those with type 2 diabetes (adjusted β = 0.01, 95% CI 0.007-0.02).CONCLUSIONS: Perceived discrimination and negative life events are associated with type 2 diabetes and glycaemic control among Ghanaians, especially in men. Further studies are needed to identify context-specific mechanisms underlying these associations.",

keywords = "glycaemic control, psychosocial stress, sub-Saharan Africans; migration, type 2 diabetes",

author = "Chilunga, {Felix P} and Schwerzel, {Pleun S} and Meeks, {Karlijn A C} and Erik Beune and Silver Bahendeka and Frank Mockenhaupt and Kerstin Klipstein-Grobusch and Charles Agyemang",

note = "Funding Information: This work was supported by the European Commission under the Framework Programme (Grant Number: 278901) and European Research Council Consolidation (Grant Number: 772244). Publisher Copyright: {\textcopyright} 2022 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK.",

year = "2023",

month = jan,

doi = "10.1111/dme.15006",

language = "English",

volume = "40",

pages = "1--10",

journal = "Diabetic Medicine",

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TY - JOUR

T1 - Associations of psychosocial stress with type 2 diabetes and glycaemic control among Ghanaians

T2 - The RODAM study

AU - Chilunga, Felix P

AU - Schwerzel, Pleun S

AU - Meeks, Karlijn A C

AU - Beune, Erik

AU - Bahendeka, Silver

AU - Mockenhaupt, Frank

AU - Klipstein-Grobusch, Kerstin

AU - Agyemang, Charles

N1 - Funding Information: This work was supported by the European Commission under the Framework Programme (Grant Number: 278901) and European Research Council Consolidation (Grant Number: 772244). Publisher Copyright: © 2022 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK.

PY - 2023/1

Y1 - 2023/1

N2 - BACKGROUND: The extent to which psychosocial stress relates to type 2 diabetes among sub-Saharan Africans is not well understood. We assessed associations of psychosocial stresses with type 2 diabetes status and glycaemic control among Ghanaians.METHODS: We used data from Research on Obesity and Diabetes among African Migrants (RODAM) study. We performed logistic and linear regression models to assess association of psychosocial stresses with type 2 diabetes and HbA1c respectively with adjustments for age, sex, education and other stresses. We also assessed moderation effects of migration status (migrant Ghanaians vs. non-migrant Ghanaians), age, sex and education by adding interaction terms in models.RESULTS: Four thousand eight hundred and forty one Ghanaians were included with 44% resident in Ghana, 62% women, mean age of 46 years and 10% having type 2 diabetes. Psychosocial stress at home and at work were not associated with type 2 diabetes or HbA1c levels. Negative life events in past 12 months were negatively associated with type 2 diabetes (adjusted odds ratio = 0.93, 95% CI 0.87-0.99). Perceived discrimination was positively associated with type 2 diabetes (aOR = 1.01, 95% CI 1.004-1.03). Both associations were more pronounced in men. Perceived discrimination was also positively associated with HbA1c levels, especially among those with type 2 diabetes (adjusted β = 0.01, 95% CI 0.007-0.02).CONCLUSIONS: Perceived discrimination and negative life events are associated with type 2 diabetes and glycaemic control among Ghanaians, especially in men. Further studies are needed to identify context-specific mechanisms underlying these associations.

AB - BACKGROUND: The extent to which psychosocial stress relates to type 2 diabetes among sub-Saharan Africans is not well understood. We assessed associations of psychosocial stresses with type 2 diabetes status and glycaemic control among Ghanaians.METHODS: We used data from Research on Obesity and Diabetes among African Migrants (RODAM) study. We performed logistic and linear regression models to assess association of psychosocial stresses with type 2 diabetes and HbA1c respectively with adjustments for age, sex, education and other stresses. We also assessed moderation effects of migration status (migrant Ghanaians vs. non-migrant Ghanaians), age, sex and education by adding interaction terms in models.RESULTS: Four thousand eight hundred and forty one Ghanaians were included with 44% resident in Ghana, 62% women, mean age of 46 years and 10% having type 2 diabetes. Psychosocial stress at home and at work were not associated with type 2 diabetes or HbA1c levels. Negative life events in past 12 months were negatively associated with type 2 diabetes (adjusted odds ratio = 0.93, 95% CI 0.87-0.99). Perceived discrimination was positively associated with type 2 diabetes (aOR = 1.01, 95% CI 1.004-1.03). Both associations were more pronounced in men. Perceived discrimination was also positively associated with HbA1c levels, especially among those with type 2 diabetes (adjusted β = 0.01, 95% CI 0.007-0.02).CONCLUSIONS: Perceived discrimination and negative life events are associated with type 2 diabetes and glycaemic control among Ghanaians, especially in men. Further studies are needed to identify context-specific mechanisms underlying these associations.

KW - glycaemic control

KW - psychosocial stress

KW - sub-Saharan Africans; migration

KW - type 2 diabetes

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U2 - 10.1111/dme.15006

DO - 10.1111/dme.15006

M3 - Article

C2 - 36373887

SN - 0742-3071

VL - 40

SP - 1

EP - 10

JO - Diabetic Medicine

JF - Diabetic Medicine

IS - 1

M1 - e15006

ER -

Associations of psychosocial stress with type 2 diabetes and glycaemic control among Ghanaians: The RODAM study

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