Associations between olfactory identification and (social) cognitive functioning: A cross-sectional study in schizophrenia patients and healthy controls

Jessica de Nijs; Julia H. Meijer; Lieuwe de Haan; Carin J. Meijer; Richard Bruggeman; Neeltje E.M. van Haren; René S. Kahn; Wiepke Cahn

doi:10.1016/j.psychres.2018.05.009

Associations between olfactory identification and (social) cognitive functioning: A cross-sectional study in schizophrenia patients and healthy controls

Jessica de Nijs^*
, Julia H. Meijer
, Lieuwe de Haan
, Carin J. Meijer
, Richard Bruggeman
, Neeltje E.M. van Haren
, René S. Kahn
, Wiepke Cahn

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Schizophrenia patients have difficulties identifying odors, possibly a marker of cognitive and social impairment. This study investigated olfactory identification (OI) differences between patients and controls, related to cognitive and social functioning in childhood and adolescence, to present state cognition and to present state social cognition. 132 schizophrenia patients and 128 healthy controls were assessed on OI performance with the Sniffin’ Sticks task. Multiple regression analyses were conducted investigating OI in association with cognitive and social functioning measures in childhood/adolescence and in association with IQ, memory, processing speed, attention, executive functioning, face recognition, emotion recognition and theory of mind. Patients had reduced OI performance compared to controls. Also, patients scored worse on childhood/adolescence cognitive and social functioning, on present state cognitive functioning and present state social cognition compared to controls. OI in patients and controls was significantly related to cognitive and social functioning in childhood/adolescence, to present state cognition and to present state social cognition, with worse functioning being associated with worse OI. In this study, findings of worse OI in patients relative to controls were replicated. We also showed associations between OI and cognitive and social functioning which are not specific to schizophrenia.

Original language	English
Pages (from-to)	147-151
Number of pages	5
Journal	Psychiatry Research
Volume	266
DOIs	https://doi.org/10.1016/j.psychres.2018.05.009
Publication status	Published - 1 Aug 2018

Keywords

Childhood/adolescent functioning
Cognition
Olfactory identification deficit
Social cognition

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10.1016/j.psychres.2018.05.009

1-s2.0-S0165178117308053-mainFinal published version, 202 KBLicence: Taverne

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title = "Associations between olfactory identification and (social) cognitive functioning: A cross-sectional study in schizophrenia patients and healthy controls",

abstract = "Schizophrenia patients have difficulties identifying odors, possibly a marker of cognitive and social impairment. This study investigated olfactory identification (OI) differences between patients and controls, related to cognitive and social functioning in childhood and adolescence, to present state cognition and to present state social cognition. 132 schizophrenia patients and 128 healthy controls were assessed on OI performance with the Sniffin{\textquoteright} Sticks task. Multiple regression analyses were conducted investigating OI in association with cognitive and social functioning measures in childhood/adolescence and in association with IQ, memory, processing speed, attention, executive functioning, face recognition, emotion recognition and theory of mind. Patients had reduced OI performance compared to controls. Also, patients scored worse on childhood/adolescence cognitive and social functioning, on present state cognitive functioning and present state social cognition compared to controls. OI in patients and controls was significantly related to cognitive and social functioning in childhood/adolescence, to present state cognition and to present state social cognition, with worse functioning being associated with worse OI. In this study, findings of worse OI in patients relative to controls were replicated. We also showed associations between OI and cognitive and social functioning which are not specific to schizophrenia.",

keywords = "Childhood/adolescent functioning, Cognition, Olfactory identification deficit, Social cognition",

author = "\{de Nijs\}, Jessica and Meijer, \{Julia H.\} and \{de Haan\}, Lieuwe and Meijer, \{Carin J.\} and Richard Bruggeman and \{van Haren\}, \{Neeltje E.M.\} and Kahn, \{Ren{\'e} S.\} and Wiepke Cahn",

note = "Funding Information: The infrastructure for the GROUP study is funded through the Geestkracht programme of the Dutch Health Research Council (ZON–MW, grant number 10–000–1001 ). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",

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doi = "10.1016/j.psychres.2018.05.009",

language = "English",

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AU - de Nijs, Jessica

AU - Meijer, Julia H.

AU - de Haan, Lieuwe

AU - Meijer, Carin J.

AU - Bruggeman, Richard

AU - van Haren, Neeltje E.M.

AU - Kahn, René S.

AU - Cahn, Wiepke

N1 - Funding Information: The infrastructure for the GROUP study is funded through the Geestkracht programme of the Dutch Health Research Council (ZON–MW, grant number 10–000–1001 ). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. Publisher Copyright: © 2018 Elsevier B.V.

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Schizophrenia patients have difficulties identifying odors, possibly a marker of cognitive and social impairment. This study investigated olfactory identification (OI) differences between patients and controls, related to cognitive and social functioning in childhood and adolescence, to present state cognition and to present state social cognition. 132 schizophrenia patients and 128 healthy controls were assessed on OI performance with the Sniffin’ Sticks task. Multiple regression analyses were conducted investigating OI in association with cognitive and social functioning measures in childhood/adolescence and in association with IQ, memory, processing speed, attention, executive functioning, face recognition, emotion recognition and theory of mind. Patients had reduced OI performance compared to controls. Also, patients scored worse on childhood/adolescence cognitive and social functioning, on present state cognitive functioning and present state social cognition compared to controls. OI in patients and controls was significantly related to cognitive and social functioning in childhood/adolescence, to present state cognition and to present state social cognition, with worse functioning being associated with worse OI. In this study, findings of worse OI in patients relative to controls were replicated. We also showed associations between OI and cognitive and social functioning which are not specific to schizophrenia.

AB - Schizophrenia patients have difficulties identifying odors, possibly a marker of cognitive and social impairment. This study investigated olfactory identification (OI) differences between patients and controls, related to cognitive and social functioning in childhood and adolescence, to present state cognition and to present state social cognition. 132 schizophrenia patients and 128 healthy controls were assessed on OI performance with the Sniffin’ Sticks task. Multiple regression analyses were conducted investigating OI in association with cognitive and social functioning measures in childhood/adolescence and in association with IQ, memory, processing speed, attention, executive functioning, face recognition, emotion recognition and theory of mind. Patients had reduced OI performance compared to controls. Also, patients scored worse on childhood/adolescence cognitive and social functioning, on present state cognitive functioning and present state social cognition compared to controls. OI in patients and controls was significantly related to cognitive and social functioning in childhood/adolescence, to present state cognition and to present state social cognition, with worse functioning being associated with worse OI. In this study, findings of worse OI in patients relative to controls were replicated. We also showed associations between OI and cognitive and social functioning which are not specific to schizophrenia.

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KW - Cognition

KW - Olfactory identification deficit

KW - Social cognition

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JO - Psychiatry Research

JF - Psychiatry Research

ER -

Associations between olfactory identification and (social) cognitive functioning: A cross-sectional study in schizophrenia patients and healthy controls

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