TY - JOUR
T1 - Associations between olfactory identification and (social) cognitive functioning
T2 - A cross-sectional study in schizophrenia patients and healthy controls
AU - de Nijs, Jessica
AU - Meijer, Julia H.
AU - de Haan, Lieuwe
AU - Meijer, Carin J.
AU - Bruggeman, Richard
AU - van Haren, Neeltje E.M.
AU - Kahn, René S.
AU - Cahn, Wiepke
N1 - Funding Information:
The infrastructure for the GROUP study is funded through the Geestkracht programme of the Dutch Health Research Council (ZON–MW, grant number 10–000–1001 ). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.
Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Schizophrenia patients have difficulties identifying odors, possibly a marker of cognitive and social impairment. This study investigated olfactory identification (OI) differences between patients and controls, related to cognitive and social functioning in childhood and adolescence, to present state cognition and to present state social cognition. 132 schizophrenia patients and 128 healthy controls were assessed on OI performance with the Sniffin’ Sticks task. Multiple regression analyses were conducted investigating OI in association with cognitive and social functioning measures in childhood/adolescence and in association with IQ, memory, processing speed, attention, executive functioning, face recognition, emotion recognition and theory of mind. Patients had reduced OI performance compared to controls. Also, patients scored worse on childhood/adolescence cognitive and social functioning, on present state cognitive functioning and present state social cognition compared to controls. OI in patients and controls was significantly related to cognitive and social functioning in childhood/adolescence, to present state cognition and to present state social cognition, with worse functioning being associated with worse OI. In this study, findings of worse OI in patients relative to controls were replicated. We also showed associations between OI and cognitive and social functioning which are not specific to schizophrenia.
AB - Schizophrenia patients have difficulties identifying odors, possibly a marker of cognitive and social impairment. This study investigated olfactory identification (OI) differences between patients and controls, related to cognitive and social functioning in childhood and adolescence, to present state cognition and to present state social cognition. 132 schizophrenia patients and 128 healthy controls were assessed on OI performance with the Sniffin’ Sticks task. Multiple regression analyses were conducted investigating OI in association with cognitive and social functioning measures in childhood/adolescence and in association with IQ, memory, processing speed, attention, executive functioning, face recognition, emotion recognition and theory of mind. Patients had reduced OI performance compared to controls. Also, patients scored worse on childhood/adolescence cognitive and social functioning, on present state cognitive functioning and present state social cognition compared to controls. OI in patients and controls was significantly related to cognitive and social functioning in childhood/adolescence, to present state cognition and to present state social cognition, with worse functioning being associated with worse OI. In this study, findings of worse OI in patients relative to controls were replicated. We also showed associations between OI and cognitive and social functioning which are not specific to schizophrenia.
KW - Childhood/adolescent functioning
KW - Cognition
KW - Olfactory identification deficit
KW - Social cognition
UR - http://www.scopus.com/inward/record.url?scp=85048510877&partnerID=8YFLogxK
U2 - 10.1016/j.psychres.2018.05.009
DO - 10.1016/j.psychres.2018.05.009
M3 - Article
AN - SCOPUS:85048510877
SN - 0165-1781
VL - 266
SP - 147
EP - 151
JO - Psychiatry Research
JF - Psychiatry Research
ER -