Associations between Fatty Acid Intakes and Plasma Phospholipid Fatty Acid Concentrations in the European Prospective Investigation into Cancer and Nutrition

Inge Huybrechts*, Inarie Jacobs, Elom K. Aglago, Sahar Yammine, Michèle Matta, Julie A. Schmidt, Corinne Casagrande, Geneviève Nicolas, Carine Biessy, Heleen Van Puyvelde, Augustin Scalbert, Jeroen W.G. Derksen, Yvonne T. van der Schouw, Sara Grioni, Pilar Amiano, Jytte Halkjær, Anne Tjønneland, José M. Huerta, Leila Luján-Barroso, Domenico PalliMarc J. Gunter, Aurora Perez-Cornago, Véronique Chajès

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Downloads (Pure)

Abstract

Background: The aim of this study is to determine the correlations between dietary fatty acid (FA) intakes and plasma phospholipid (PL) FA levels in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: The dietary intake of 60 individual FAs was estimated using centre-specific validated dietary questionnaires. Plasma PL FA concentrations of these FAs were measured in non-fasting venous plasma samples in nested case-control studies within the EPIC cohort (n = 4923, using only non-cases). Spearman rank correlations were calculated to determine associations between FA intakes and plasma PL FA levels. Results: Correlations between FA intakes and circulating levels were low to moderately high (−0.233 and 0.554). Moderate positive correlations were found for total long-chain n-3 poly-unsaturated FA (PUFA) (r = 0.354) with the highest (r = 0.406) for n-3 PUFA docosahexaenoic acid (DHA). Moderate positive correlations were also found for the non-endogenously synthesized trans-FA (r = 0.461 for total trans-FA C16-18; r = 0.479 for industrial trans-FA (elaidic acid)). Conclusions: Our findings indicate that dietary FA intakes might influence the plasma PL FA status to a certain extent for several specific FAs. The stronger positive correlations for health-enhancing long-chain PUFAs and the health-deteriorating trans-FA that are not endogenously produced are valuable for future cancer prevention public health interventions.

Original languageEnglish
Article number3695
Pages (from-to)1-15
Number of pages15
JournalNutrients
Volume15
Issue number17
DOIs
Publication statusPublished - Sept 2023

Keywords

  • dietary intake
  • fatty acids
  • plasma phospholipid concentrations

Fingerprint

Dive into the research topics of 'Associations between Fatty Acid Intakes and Plasma Phospholipid Fatty Acid Concentrations in the European Prospective Investigation into Cancer and Nutrition'. Together they form a unique fingerprint.

Cite this