Associations between Fatty Acid Intakes and Plasma Phospholipid Fatty Acid Concentrations in the European Prospective Investigation into Cancer and Nutrition

Inge Huybrechts; Inarie Jacobs; Elom K. Aglago; Sahar Yammine; Michèle Matta; Julie A. Schmidt; Corinne Casagrande; Geneviève Nicolas; Carine Biessy; Heleen Van Puyvelde; Augustin Scalbert; Jeroen W.G. Derksen; Yvonne T. van der Schouw; Sara Grioni; Pilar Amiano; Jytte Halkjær; Anne Tjønneland; José M. Huerta; Leila Luján-Barroso; Domenico Palli; Marc J. Gunter; Aurora Perez-Cornago; Véronique Chajès

doi:10.3390/nu15173695

Associations between Fatty Acid Intakes and Plasma Phospholipid Fatty Acid Concentrations in the European Prospective Investigation into Cancer and Nutrition

Inge Huybrechts^*, Inarie Jacobs, Elom K. Aglago, Sahar Yammine, Michèle Matta, Julie A. Schmidt, Corinne Casagrande, Geneviève Nicolas, Carine Biessy, Heleen Van Puyvelde, Augustin Scalbert, Jeroen W.G. Derksen, Yvonne T. van der Schouw, Sara Grioni, Pilar Amiano, Jytte Halkjær, Anne Tjønneland, José M. Huerta, Leila Luján-Barroso, Domenico PalliMarc J. Gunter, Aurora Perez-Cornago, Véronique Chajès

^*Corresponding author for this work

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Abstract

Background: The aim of this study is to determine the correlations between dietary fatty acid (FA) intakes and plasma phospholipid (PL) FA levels in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: The dietary intake of 60 individual FAs was estimated using centre-specific validated dietary questionnaires. Plasma PL FA concentrations of these FAs were measured in non-fasting venous plasma samples in nested case-control studies within the EPIC cohort (n = 4923, using only non-cases). Spearman rank correlations were calculated to determine associations between FA intakes and plasma PL FA levels. Results: Correlations between FA intakes and circulating levels were low to moderately high (−0.233 and 0.554). Moderate positive correlations were found for total long-chain n-3 poly-unsaturated FA (PUFA) (r = 0.354) with the highest (r = 0.406) for n-3 PUFA docosahexaenoic acid (DHA). Moderate positive correlations were also found for the non-endogenously synthesized trans-FA (r = 0.461 for total trans-FA C16-18; r = 0.479 for industrial trans-FA (elaidic acid)). Conclusions: Our findings indicate that dietary FA intakes might influence the plasma PL FA status to a certain extent for several specific FAs. The stronger positive correlations for health-enhancing long-chain PUFAs and the health-deteriorating trans-FA that are not endogenously produced are valuable for future cancer prevention public health interventions.

Original language	English
Article number	3695
Pages (from-to)	1-15
Number of pages	15
Journal	Nutrients
Volume	15
Issue number	17
DOIs	https://doi.org/10.3390/nu15173695
Publication status	Published - Sept 2023

Keywords

dietary intake
fatty acids
plasma phospholipid concentrations

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nutrients-15-03695Final published version, 472 KBLicence: CC BY

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Huybrechts, I., Jacobs, I., Aglago, E. K., Yammine, S., Matta, M., Schmidt, J. A., Casagrande, C., Nicolas, G., Biessy, C., Van Puyvelde, H., Scalbert, A., Derksen, J. W. G., van der Schouw, Y. T., Grioni, S., Amiano, P., Halkjær, J., Tjønneland, A., Huerta, J. M., Luján-Barroso, L., ... Chajès, V. (2023). Associations between Fatty Acid Intakes and Plasma Phospholipid Fatty Acid Concentrations in the European Prospective Investigation into Cancer and Nutrition. Nutrients, 15(17), 1-15. Article 3695. https://doi.org/10.3390/nu15173695

@article{852902918a894a8a81a99bcd6b931d3b,

title = "Associations between Fatty Acid Intakes and Plasma Phospholipid Fatty Acid Concentrations in the European Prospective Investigation into Cancer and Nutrition",

abstract = "Background: The aim of this study is to determine the correlations between dietary fatty acid (FA) intakes and plasma phospholipid (PL) FA levels in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: The dietary intake of 60 individual FAs was estimated using centre-specific validated dietary questionnaires. Plasma PL FA concentrations of these FAs were measured in non-fasting venous plasma samples in nested case-control studies within the EPIC cohort (n = 4923, using only non-cases). Spearman rank correlations were calculated to determine associations between FA intakes and plasma PL FA levels. Results: Correlations between FA intakes and circulating levels were low to moderately high (−0.233 and 0.554). Moderate positive correlations were found for total long-chain n-3 poly-unsaturated FA (PUFA) (r = 0.354) with the highest (r = 0.406) for n-3 PUFA docosahexaenoic acid (DHA). Moderate positive correlations were also found for the non-endogenously synthesized trans-FA (r = 0.461 for total trans-FA C16-18; r = 0.479 for industrial trans-FA (elaidic acid)). Conclusions: Our findings indicate that dietary FA intakes might influence the plasma PL FA status to a certain extent for several specific FAs. The stronger positive correlations for health-enhancing long-chain PUFAs and the health-deteriorating trans-FA that are not endogenously produced are valuable for future cancer prevention public health interventions.",

keywords = "dietary intake, fatty acids, plasma phospholipid concentrations",

author = "Inge Huybrechts and Inarie Jacobs and Aglago, {Elom K.} and Sahar Yammine and Mich{\`e}le Matta and Schmidt, {Julie A.} and Corinne Casagrande and Genevi{\`e}ve Nicolas and Carine Biessy and {Van Puyvelde}, Heleen and Augustin Scalbert and Derksen, {Jeroen W.G.} and {van der Schouw}, {Yvonne T.} and Sara Grioni and Pilar Amiano and Jytte Halkj{\ae}r and Anne Tj{\o}nneland and Huerta, {Jos{\'e} M.} and Leila Luj{\'a}n-Barroso and Domenico Palli and Gunter, {Marc J.} and Aurora Perez-Cornago and V{\'e}ronique Chaj{\`e}s",

note = "Funding Information: The coordination of EPIC is financially supported by International Agency for Research on Cancer (IARC) and also by the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London which has additional infrastructure support provided by the NIHR Imperial Biomedical Research Centre (BRC). The national cohorts are supported by: Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle G{\'e}n{\'e}rale de l{\textquoteright}Education Nationale, Institut National de la Sant{\'e} et de la Recherche M{\'e}dicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Federal Ministry of Education and Research (BMBF) (Germany); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy, Compagnia di SanPaolo and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); Health Research Fund (FIS)—Instituto de Salud Carlos III (ISCIII), Regional Governments of Andaluc{\'i}a, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology—ICO (Spain); Swedish Cancer Society, Swedish Research Council and County Councils of Sk{\aa}ne and V{\"a}sterbotten (Sweden); Cancer Research UK (14136 to EPIC-Norfolk; C8221/A29017 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk; MR/M012190/1 to EPIC-Oxford) (United Kingdom). This study was conducted as part of the EXPANSE project funded by the European Union{\textquoteright}s Horizon 2020 research and innovation program (grant agreement No. 874627). Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = sep,

doi = "10.3390/nu15173695",

language = "English",

volume = "15",

pages = "1--15",

number = "17",

}

Huybrechts, I, Jacobs, I, Aglago, EK, Yammine, S, Matta, M, Schmidt, JA, Casagrande, C, Nicolas, G, Biessy, C, Van Puyvelde, H, Scalbert, A, Derksen, JWG , van der Schouw, YT, Grioni, S, Amiano, P, Halkjær, J, Tjønneland, A, Huerta, JM, Luján-Barroso, L, Palli, D, Gunter, MJ, Perez-Cornago, A & Chajès, V 2023, 'Associations between Fatty Acid Intakes and Plasma Phospholipid Fatty Acid Concentrations in the European Prospective Investigation into Cancer and Nutrition', Nutrients, vol. 15, no. 17, 3695, pp. 1-15. https://doi.org/10.3390/nu15173695

TY - JOUR

T1 - Associations between Fatty Acid Intakes and Plasma Phospholipid Fatty Acid Concentrations in the European Prospective Investigation into Cancer and Nutrition

AU - Huybrechts, Inge

AU - Jacobs, Inarie

AU - Aglago, Elom K.

AU - Yammine, Sahar

AU - Matta, Michèle

AU - Schmidt, Julie A.

AU - Casagrande, Corinne

AU - Nicolas, Geneviève

AU - Biessy, Carine

AU - Van Puyvelde, Heleen

AU - Scalbert, Augustin

AU - Derksen, Jeroen W.G.

AU - van der Schouw, Yvonne T.

AU - Grioni, Sara

AU - Amiano, Pilar

AU - Halkjær, Jytte

AU - Tjønneland, Anne

AU - Huerta, José M.

AU - Luján-Barroso, Leila

AU - Palli, Domenico

AU - Gunter, Marc J.

AU - Perez-Cornago, Aurora

AU - Chajès, Véronique

N1 - Funding Information: The coordination of EPIC is financially supported by International Agency for Research on Cancer (IARC) and also by the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London which has additional infrastructure support provided by the NIHR Imperial Biomedical Research Centre (BRC). The national cohorts are supported by: Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Federal Ministry of Education and Research (BMBF) (Germany); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy, Compagnia di SanPaolo and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); Health Research Fund (FIS)—Instituto de Salud Carlos III (ISCIII), Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology—ICO (Spain); Swedish Cancer Society, Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden); Cancer Research UK (14136 to EPIC-Norfolk; C8221/A29017 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk; MR/M012190/1 to EPIC-Oxford) (United Kingdom). This study was conducted as part of the EXPANSE project funded by the European Union’s Horizon 2020 research and innovation program (grant agreement No. 874627). Publisher Copyright: © 2023 by the authors.

PY - 2023/9

Y1 - 2023/9

N2 - Background: The aim of this study is to determine the correlations between dietary fatty acid (FA) intakes and plasma phospholipid (PL) FA levels in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: The dietary intake of 60 individual FAs was estimated using centre-specific validated dietary questionnaires. Plasma PL FA concentrations of these FAs were measured in non-fasting venous plasma samples in nested case-control studies within the EPIC cohort (n = 4923, using only non-cases). Spearman rank correlations were calculated to determine associations between FA intakes and plasma PL FA levels. Results: Correlations between FA intakes and circulating levels were low to moderately high (−0.233 and 0.554). Moderate positive correlations were found for total long-chain n-3 poly-unsaturated FA (PUFA) (r = 0.354) with the highest (r = 0.406) for n-3 PUFA docosahexaenoic acid (DHA). Moderate positive correlations were also found for the non-endogenously synthesized trans-FA (r = 0.461 for total trans-FA C16-18; r = 0.479 for industrial trans-FA (elaidic acid)). Conclusions: Our findings indicate that dietary FA intakes might influence the plasma PL FA status to a certain extent for several specific FAs. The stronger positive correlations for health-enhancing long-chain PUFAs and the health-deteriorating trans-FA that are not endogenously produced are valuable for future cancer prevention public health interventions.

AB - Background: The aim of this study is to determine the correlations between dietary fatty acid (FA) intakes and plasma phospholipid (PL) FA levels in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: The dietary intake of 60 individual FAs was estimated using centre-specific validated dietary questionnaires. Plasma PL FA concentrations of these FAs were measured in non-fasting venous plasma samples in nested case-control studies within the EPIC cohort (n = 4923, using only non-cases). Spearman rank correlations were calculated to determine associations between FA intakes and plasma PL FA levels. Results: Correlations between FA intakes and circulating levels were low to moderately high (−0.233 and 0.554). Moderate positive correlations were found for total long-chain n-3 poly-unsaturated FA (PUFA) (r = 0.354) with the highest (r = 0.406) for n-3 PUFA docosahexaenoic acid (DHA). Moderate positive correlations were also found for the non-endogenously synthesized trans-FA (r = 0.461 for total trans-FA C16-18; r = 0.479 for industrial trans-FA (elaidic acid)). Conclusions: Our findings indicate that dietary FA intakes might influence the plasma PL FA status to a certain extent for several specific FAs. The stronger positive correlations for health-enhancing long-chain PUFAs and the health-deteriorating trans-FA that are not endogenously produced are valuable for future cancer prevention public health interventions.

KW - dietary intake

KW - fatty acids

KW - plasma phospholipid concentrations

UR - http://www.scopus.com/inward/record.url?scp=85170349131&partnerID=8YFLogxK

U2 - 10.3390/nu15173695

DO - 10.3390/nu15173695

M3 - Article

C2 - 37686727

AN - SCOPUS:85170349131

SN - 2072-6643

VL - 15

SP - 1

EP - 15

JO - Nutrients

JF - Nutrients

IS - 17

M1 - 3695

ER -

Associations between Fatty Acid Intakes and Plasma Phospholipid Fatty Acid Concentrations in the European Prospective Investigation into Cancer and Nutrition

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