Associations between dietary inflammatory scores and biomarkers of inflammation in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Lucie Lécuyer; Nasser Laouali; Vivian Viallon; Fanny Artaud; James R Hébert; Nitin Shivappa; Antonio Agudo; Anne Tjønneland; Lene Mellemkjær; Rudolf Kaaks; Verena A Katzke; Matthias B Schulze; Pauline Frenoy; Francesca Romana Mancini; Maria Santucci De Magistris; Alessandra Macciotta; Giovanna Masala; Claudia Agnoli; Rosario Tumino; Jolanda M A Boer; W M Monique Verschuren; Torill M Enget Jensen; Karina Standahl Olsen; Guri Skeie; María-Dolores Chirlaque; Dafina Petrova; Carlota Castro-Espin; J Ramón Quirós; Marcela Guevara; Pilar Amiano; Yan Borné; Maria Sandström; Lena Maria Nilsson; Alicia K Heath; Ana-Lucia Mayen; Inge Huybrechts; Elisabete Weiderpass; Marie-Christine Boutron-Ruault; Laure Dossus; Sabina Rinaldi; Thérèse Truong

doi:10.1016/j.clnu.2023.05.012

Associations between dietary inflammatory scores and biomarkers of inflammation in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Lucie Lécuyer, Nasser Laouali, Vivian Viallon, Fanny Artaud, James R Hébert, Nitin Shivappa, Antonio Agudo, Anne Tjønneland, Lene Mellemkjær, Rudolf Kaaks, Verena A Katzke, Matthias B Schulze, Pauline Frenoy, Francesca Romana Mancini, Maria Santucci De Magistris, Alessandra Macciotta, Giovanna Masala, Claudia Agnoli, Rosario Tumino, Jolanda M A BoerW M Monique Verschuren, Torill M Enget Jensen, Karina Standahl Olsen, Guri Skeie, María-Dolores Chirlaque, Dafina Petrova, Carlota Castro-Espin, J Ramón Quirós, Marcela Guevara, Pilar Amiano, Yan Borné, Maria Sandström, Lena Maria Nilsson, Alicia K Heath, Ana-Lucia Mayen, Inge Huybrechts, Elisabete Weiderpass, Marie-Christine Boutron-Ruault, Laure Dossus, Sabina Rinaldi, Thérèse Truong^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

BACKGROUND: Since the first version of the dietary inflammatory index (DII®) developed in the past decade, several other versions have been developed. However, to date no study has attempted to compare these versions with respect to their associations with biomarkers of inflammation.

OBJECTIVE: We aimed to investigate the relationship between four dietary inflammatory scores [DII, two energy-adjusted derivatives (E-DII and E-DII r), and the Inflammatory Score of the Diet (ISD)], and circulating levels of several inflammatory markers and adipokines.

METHODS: This study included 17 637 participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort with at least one marker of inflammation measured in blood. Associations between the four scores and C-reactive protein (CRP), interleukin (IL)6, IL10, IL1RA, tumor necrosis factor-α (TNFα), soluble tumor necrosis factor receptor-1 (sTNFR1), sTNFR2, leptin, soluble leptin receptor (sLeptin R), adiponectin, and High Molecular Weight (HMW) adiponectin were evaluated using multivariable linear regressions adjusted for potential confounders.

RESULTS: Positive associations were observed between the four dietary inflammatory scores and levels of CRP, IL6, sTNFR1, sTNFR2 and leptin. However, only the DII and the ISD were positively associated with IL1RA levels and only the DII and the E-DII r were positively associated with TNFα levels. The proportion of variance of each biomarker explained by the scores was lower than 2%, which was equivalent to the variance explained by smoking status but much lower than that explained by body mass index.

CONCLUSIONS: Our results suggest that the four dietary inflammatory scores were associated with some biomarkers of inflammation and could be used to assess the inflammatory potential of diet in European adults but are not sufficient to capture the inflammatory status of an individual. These findings can help to better understand the inflammatory potential of diet, but they need to be replicated in studies with repeated dietary measurements.

Original language	English
Pages (from-to)	1115-1125
Number of pages	11
Journal	Clinical Nutrition
Volume	42
Issue number	7
DOIs	https://doi.org/10.1016/j.clnu.2023.05.012
Publication status	Published - Jul 2023

Keywords

Adiponectin
Adult
Biomarkers
C-Reactive Protein/metabolism
Diet
Humans
Inflammation
Leptin
Neoplasms
Prospective Studies
Tumor Necrosis Factor-alpha

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Lécuyer, L., Laouali, N., Viallon, V., Artaud, F., Hébert, J. R., Shivappa, N., Agudo, A., Tjønneland, A., Mellemkjær, L., Kaaks, R., Katzke, V. A., Schulze, M. B., Frenoy, P., Mancini, F. R., De Magistris, M. S., Macciotta, A., Masala, G., Agnoli, C., Tumino, R., ... Truong, T. (2023). Associations between dietary inflammatory scores and biomarkers of inflammation in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Clinical Nutrition, 42(7), 1115-1125. https://doi.org/10.1016/j.clnu.2023.05.012

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title = "Associations between dietary inflammatory scores and biomarkers of inflammation in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort",

abstract = "BACKGROUND: Since the first version of the dietary inflammatory index (DII{\textregistered}) developed in the past decade, several other versions have been developed. However, to date no study has attempted to compare these versions with respect to their associations with biomarkers of inflammation.OBJECTIVE: We aimed to investigate the relationship between four dietary inflammatory scores [DII, two energy-adjusted derivatives (E-DII and E-DII r), and the Inflammatory Score of the Diet (ISD)], and circulating levels of several inflammatory markers and adipokines. METHODS: This study included 17 637 participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort with at least one marker of inflammation measured in blood. Associations between the four scores and C-reactive protein (CRP), interleukin (IL)6, IL10, IL1RA, tumor necrosis factor-α (TNFα), soluble tumor necrosis factor receptor-1 (sTNFR1), sTNFR2, leptin, soluble leptin receptor (sLeptin R), adiponectin, and High Molecular Weight (HMW) adiponectin were evaluated using multivariable linear regressions adjusted for potential confounders.RESULTS: Positive associations were observed between the four dietary inflammatory scores and levels of CRP, IL6, sTNFR1, sTNFR2 and leptin. However, only the DII and the ISD were positively associated with IL1RA levels and only the DII and the E-DII r were positively associated with TNFα levels. The proportion of variance of each biomarker explained by the scores was lower than 2%, which was equivalent to the variance explained by smoking status but much lower than that explained by body mass index. CONCLUSIONS: Our results suggest that the four dietary inflammatory scores were associated with some biomarkers of inflammation and could be used to assess the inflammatory potential of diet in European adults but are not sufficient to capture the inflammatory status of an individual. These findings can help to better understand the inflammatory potential of diet, but they need to be replicated in studies with repeated dietary measurements.",

keywords = "Adiponectin, Adult, Biomarkers, C-Reactive Protein/metabolism, Diet, Humans, Inflammation, Leptin, Neoplasms, Prospective Studies, Tumor Necrosis Factor-alpha",

author = "Lucie L{\'e}cuyer and Nasser Laouali and Vivian Viallon and Fanny Artaud and H{\'e}bert, {James R} and Nitin Shivappa and Antonio Agudo and Anne Tj{\o}nneland and Lene Mellemkj{\ae}r and Rudolf Kaaks and Katzke, {Verena A} and Schulze, {Matthias B} and Pauline Frenoy and Mancini, {Francesca Romana} and {De Magistris}, {Maria Santucci} and Alessandra Macciotta and Giovanna Masala and Claudia Agnoli and Rosario Tumino and Boer, {Jolanda M A} and Verschuren, {W M Monique} and {Enget Jensen}, {Torill M} and Olsen, {Karina Standahl} and Guri Skeie and Mar{\'i}a-Dolores Chirlaque and Dafina Petrova and Carlota Castro-Espin and Quir{\'o}s, {J Ram{\'o}n} and Marcela Guevara and Pilar Amiano and Yan Born{\'e} and Maria Sandstr{\"o}m and Nilsson, {Lena Maria} and Heath, {Alicia K} and Ana-Lucia Mayen and Inge Huybrechts and Elisabete Weiderpass and Marie-Christine Boutron-Ruault and Laure Dossus and Sabina Rinaldi and Th{\'e}r{\`e}se Truong",

note = "Publisher Copyright: {\textcopyright} 2023",

year = "2023",

month = jul,

doi = "10.1016/j.clnu.2023.05.012",

language = "English",

volume = "42",

pages = "1115--1125",

journal = "Clinical Nutrition",

issn = "0261-5614",

publisher = "Churchill Livingstone",

number = "7",

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Lécuyer, L, Laouali, N, Viallon, V, Artaud, F, Hébert, JR, Shivappa, N, Agudo, A, Tjønneland, A, Mellemkjær, L, Kaaks, R, Katzke, VA, Schulze, MB, Frenoy, P, Mancini, FR, De Magistris, MS, Macciotta, A, Masala, G, Agnoli, C, Tumino, R, Boer, JMA, Verschuren, WMM, Enget Jensen, TM, Olsen, KS, Skeie, G, Chirlaque, M-D, Petrova, D, Castro-Espin, C, Quirós, JR, Guevara, M, Amiano, P, Borné, Y, Sandström, M, Nilsson, LM, Heath, AK, Mayen, A-L, Huybrechts, I, Weiderpass, E, Boutron-Ruault, M-C, Dossus, L, Rinaldi, S & Truong, T 2023, 'Associations between dietary inflammatory scores and biomarkers of inflammation in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort', Clinical Nutrition, vol. 42, no. 7, pp. 1115-1125. https://doi.org/10.1016/j.clnu.2023.05.012

TY - JOUR

T1 - Associations between dietary inflammatory scores and biomarkers of inflammation in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

AU - Lécuyer, Lucie

AU - Laouali, Nasser

AU - Viallon, Vivian

AU - Artaud, Fanny

AU - Hébert, James R

AU - Shivappa, Nitin

AU - Agudo, Antonio

AU - Tjønneland, Anne

AU - Mellemkjær, Lene

AU - Kaaks, Rudolf

AU - Katzke, Verena A

AU - Schulze, Matthias B

AU - Frenoy, Pauline

AU - Mancini, Francesca Romana

AU - De Magistris, Maria Santucci

AU - Macciotta, Alessandra

AU - Masala, Giovanna

AU - Agnoli, Claudia

AU - Tumino, Rosario

AU - Boer, Jolanda M A

AU - Verschuren, W M Monique

AU - Enget Jensen, Torill M

AU - Olsen, Karina Standahl

AU - Skeie, Guri

AU - Chirlaque, María-Dolores

AU - Petrova, Dafina

AU - Castro-Espin, Carlota

AU - Quirós, J Ramón

AU - Guevara, Marcela

AU - Amiano, Pilar

AU - Borné, Yan

AU - Sandström, Maria

AU - Nilsson, Lena Maria

AU - Heath, Alicia K

AU - Mayen, Ana-Lucia

AU - Huybrechts, Inge

AU - Weiderpass, Elisabete

AU - Boutron-Ruault, Marie-Christine

AU - Dossus, Laure

AU - Rinaldi, Sabina

AU - Truong, Thérèse

PY - 2023/7

Y1 - 2023/7

N2 - BACKGROUND: Since the first version of the dietary inflammatory index (DII®) developed in the past decade, several other versions have been developed. However, to date no study has attempted to compare these versions with respect to their associations with biomarkers of inflammation.OBJECTIVE: We aimed to investigate the relationship between four dietary inflammatory scores [DII, two energy-adjusted derivatives (E-DII and E-DII r), and the Inflammatory Score of the Diet (ISD)], and circulating levels of several inflammatory markers and adipokines. METHODS: This study included 17 637 participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort with at least one marker of inflammation measured in blood. Associations between the four scores and C-reactive protein (CRP), interleukin (IL)6, IL10, IL1RA, tumor necrosis factor-α (TNFα), soluble tumor necrosis factor receptor-1 (sTNFR1), sTNFR2, leptin, soluble leptin receptor (sLeptin R), adiponectin, and High Molecular Weight (HMW) adiponectin were evaluated using multivariable linear regressions adjusted for potential confounders.RESULTS: Positive associations were observed between the four dietary inflammatory scores and levels of CRP, IL6, sTNFR1, sTNFR2 and leptin. However, only the DII and the ISD were positively associated with IL1RA levels and only the DII and the E-DII r were positively associated with TNFα levels. The proportion of variance of each biomarker explained by the scores was lower than 2%, which was equivalent to the variance explained by smoking status but much lower than that explained by body mass index. CONCLUSIONS: Our results suggest that the four dietary inflammatory scores were associated with some biomarkers of inflammation and could be used to assess the inflammatory potential of diet in European adults but are not sufficient to capture the inflammatory status of an individual. These findings can help to better understand the inflammatory potential of diet, but they need to be replicated in studies with repeated dietary measurements.

AB - BACKGROUND: Since the first version of the dietary inflammatory index (DII®) developed in the past decade, several other versions have been developed. However, to date no study has attempted to compare these versions with respect to their associations with biomarkers of inflammation.OBJECTIVE: We aimed to investigate the relationship between four dietary inflammatory scores [DII, two energy-adjusted derivatives (E-DII and E-DII r), and the Inflammatory Score of the Diet (ISD)], and circulating levels of several inflammatory markers and adipokines. METHODS: This study included 17 637 participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort with at least one marker of inflammation measured in blood. Associations between the four scores and C-reactive protein (CRP), interleukin (IL)6, IL10, IL1RA, tumor necrosis factor-α (TNFα), soluble tumor necrosis factor receptor-1 (sTNFR1), sTNFR2, leptin, soluble leptin receptor (sLeptin R), adiponectin, and High Molecular Weight (HMW) adiponectin were evaluated using multivariable linear regressions adjusted for potential confounders.RESULTS: Positive associations were observed between the four dietary inflammatory scores and levels of CRP, IL6, sTNFR1, sTNFR2 and leptin. However, only the DII and the ISD were positively associated with IL1RA levels and only the DII and the E-DII r were positively associated with TNFα levels. The proportion of variance of each biomarker explained by the scores was lower than 2%, which was equivalent to the variance explained by smoking status but much lower than that explained by body mass index. CONCLUSIONS: Our results suggest that the four dietary inflammatory scores were associated with some biomarkers of inflammation and could be used to assess the inflammatory potential of diet in European adults but are not sufficient to capture the inflammatory status of an individual. These findings can help to better understand the inflammatory potential of diet, but they need to be replicated in studies with repeated dietary measurements.

KW - Adiponectin

KW - Adult

KW - Biomarkers

KW - C-Reactive Protein/metabolism

KW - Diet

KW - Humans

KW - Inflammation

KW - Leptin

KW - Neoplasms

KW - Prospective Studies

KW - Tumor Necrosis Factor-alpha

UR - http://www.scopus.com/inward/record.url?scp=85160866795&partnerID=8YFLogxK

U2 - 10.1016/j.clnu.2023.05.012

DO - 10.1016/j.clnu.2023.05.012

M3 - Article

C2 - 37271707

SN - 0261-5614

VL - 42

SP - 1115

EP - 1125

JO - Clinical Nutrition

JF - Clinical Nutrition

IS - 7

ER -

Associations between dietary inflammatory scores and biomarkers of inflammation in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

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Keywords

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