Association study of copy number variants with brain volume in schizophrenia patients and healthy controls

A.F. Terwisscha van Scheltinga; S.C. Bakker; N.E.M. van Haren; J.E. Voskamp; H.B.M. Boos; J.A.S. Vorstman; W. Cahn; H.E. Hulshoff Pol; R.A. Ophoff; R.S. Kahn

doi:10.1016/j.psychres.2012.04.007

Association study of copy number variants with brain volume in schizophrenia patients and healthy controls

A.F. Terwisscha van Scheltinga, S.C. Bakker, N.E.M. van Haren, J.E. Voskamp, H.B.M. Boos, J.A.S. Vorstman, W. Cahn, H.E. Hulshoff Pol, R.A. Ophoff, R.S. Kahn

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Schizophrenia patients have more copy number variations (CNVs) than healthy controls, and reduced brain volumes. Although this could suggest a causal relationship, we found no association between global CNV burden and three brain volume measures (on a MRI scan) in a sample of 173 schizophrenia patients and 176 healthy controls.

Original language	English
Pages (from-to)	1011-1013
Number of pages	3
Journal	Psychiatry Research
Volume	200
Issue number	2-3
DOIs	https://doi.org/10.1016/j.psychres.2012.04.007
Publication status	Published - 30 Dec 2012

Keywords

Adult
Brain
DNA Copy Number Variations
Female
Genetic Predisposition to Disease
Genotype
Humans
Magnetic Resonance Imaging
Male
Organ Size
Schizophrenia
Journal Article
Research Support, Non-U.S. Gov't

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10.1016/j.psychres.2012.04.007

http://www.ncbi.nlm.nih.gov/pubmed/22551941

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Terwisscha van Scheltinga, A. F., Bakker, S. C., van Haren, N. E. M., Voskamp, J. E., Boos, H. B. M., Vorstman, J. A. S., Cahn, W., Hulshoff Pol, H. E., Ophoff, R. A., & Kahn, R. S. (2012). Association study of copy number variants with brain volume in schizophrenia patients and healthy controls. Psychiatry Research, 200(2-3), 1011-1013. https://doi.org/10.1016/j.psychres.2012.04.007

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abstract = "Schizophrenia patients have more copy number variations (CNVs) than healthy controls, and reduced brain volumes. Although this could suggest a causal relationship, we found no association between global CNV burden and three brain volume measures (on a MRI scan) in a sample of 173 schizophrenia patients and 176 healthy controls.",

keywords = "Adult, Brain, DNA Copy Number Variations, Female, Genetic Predisposition to Disease, Genotype, Humans, Magnetic Resonance Imaging, Male, Organ Size, Schizophrenia, Journal Article, Research Support, Non-U.S. Gov't",

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doi = "10.1016/j.psychres.2012.04.007",

language = "English",

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AU - Terwisscha van Scheltinga, A.F.

AU - Bakker, S.C.

AU - van Haren, N.E.M.

AU - Voskamp, J.E.

AU - Boos, H.B.M.

AU - Vorstman, J.A.S.

AU - Cahn, W.

AU - Hulshoff Pol, H.E.

AU - Ophoff, R.A.

AU - Kahn, R.S.

PY - 2012/12/30

Y1 - 2012/12/30

N2 - Schizophrenia patients have more copy number variations (CNVs) than healthy controls, and reduced brain volumes. Although this could suggest a causal relationship, we found no association between global CNV burden and three brain volume measures (on a MRI scan) in a sample of 173 schizophrenia patients and 176 healthy controls.

AB - Schizophrenia patients have more copy number variations (CNVs) than healthy controls, and reduced brain volumes. Although this could suggest a causal relationship, we found no association between global CNV burden and three brain volume measures (on a MRI scan) in a sample of 173 schizophrenia patients and 176 healthy controls.

KW - Adult

KW - Brain

KW - DNA Copy Number Variations

KW - Female

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Organ Size

KW - Schizophrenia

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.psychres.2012.04.007

DO - 10.1016/j.psychres.2012.04.007

M3 - Article

C2 - 22551941

SN - 0165-1781

VL - 200

SP - 1011

EP - 1013

JO - Psychiatry Research

JF - Psychiatry Research

IS - 2-3

ER -

Association study of copy number variants with brain volume in schizophrenia patients and healthy controls

Abstract

Keywords

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