Association of fibrotic markers with diastolic function after STEMI

Lawien Al Ali; Wouter C. Meijers; Iris E. Beldhuis; Hilde E. Groot; Erik Lipsic; Dirk J. van Veldhuisen; Adriaan A. Voors; Iwan C.C. van der Horst; Rudolf A. de Boer; Pim van der Harst

doi:10.1038/s41598-024-69926-y

Association of fibrotic markers with diastolic function after STEMI

Lawien Al Ali^*, Wouter C. Meijers, Iris E. Beldhuis, Hilde E. Groot, Erik Lipsic, Dirk J. van Veldhuisen, Adriaan A. Voors, Iwan C.C. van der Horst, Rudolf A. de Boer, Pim van der Harst

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Galectin-3 and Suppression of tumorigenicity-2 (ST2) are known markers of cardiac fibrosis. We investigated the prognostic value of fibrotic markers for the development of diastolic dysfunction and long-term outcome in patients suffering an ST-elevated myocardial infarction (STEMI). We analyzed 236 patients from the GIPS-III cohort with available echocardiographic studies and plasma measurements at hospitalization and after 4 months follow-up. Adjusted logistic mixed effects modelling revealed no association between the occurrence of diastolic dysfunction over time with abnormal plasma levels of galectin-3 and ST2. We observed no differences regarding survival outcome at follow-up of 5 years between patients with normal versus abnormal values in both galectin-3 (P = 0.75), and ST2 (P = 0.85). In conclusion, galectin-3 and sST2 were not associated with the development of diastolic dysfunction in non-diabetic patients that presented with a STEMI.

Original language	English
Article number	19122
Number of pages	11
Journal	Scientific Reports
Volume	14
Issue number	1
DOIs	https://doi.org/10.1038/s41598-024-69926-y
Publication status	Published - 18 Aug 2024

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s41598-024-69926-yFinal published version, 1.33 MBLicence: CC BY-NC-ND

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@article{0691ca09e6c74a6690f58b73560ef449,

title = "Association of fibrotic markers with diastolic function after STEMI",

abstract = "Galectin-3 and Suppression of tumorigenicity-2 (ST2) are known markers of cardiac fibrosis. We investigated the prognostic value of fibrotic markers for the development of diastolic dysfunction and long-term outcome in patients suffering an ST-elevated myocardial infarction (STEMI). We analyzed 236 patients from the GIPS-III cohort with available echocardiographic studies and plasma measurements at hospitalization and after 4 months follow-up. Adjusted logistic mixed effects modelling revealed no association between the occurrence of diastolic dysfunction over time with abnormal plasma levels of galectin-3 and ST2. We observed no differences regarding survival outcome at follow-up of 5 years between patients with normal versus abnormal values in both galectin-3 (P = 0.75), and ST2 (P = 0.85). In conclusion, galectin-3 and sST2 were not associated with the development of diastolic dysfunction in non-diabetic patients that presented with a STEMI.",

author = "{Al Ali}, Lawien and Meijers, {Wouter C.} and Beldhuis, {Iris E.} and Groot, {Hilde E.} and Erik Lipsic and {van Veldhuisen}, {Dirk J.} and Voors, {Adriaan A.} and {van der Horst}, {Iwan C.C.} and {de Boer}, {Rudolf A.} and {van der Harst}, Pim",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = aug,

day = "18",

doi = "10.1038/s41598-024-69926-y",

language = "English",

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journal = "Scientific Reports",

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T1 - Association of fibrotic markers with diastolic function after STEMI

AU - Al Ali, Lawien

AU - Meijers, Wouter C.

AU - Beldhuis, Iris E.

AU - Groot, Hilde E.

AU - Lipsic, Erik

AU - van Veldhuisen, Dirk J.

AU - Voors, Adriaan A.

AU - van der Horst, Iwan C.C.

AU - de Boer, Rudolf A.

AU - van der Harst, Pim

PY - 2024/8/18

Y1 - 2024/8/18

N2 - Galectin-3 and Suppression of tumorigenicity-2 (ST2) are known markers of cardiac fibrosis. We investigated the prognostic value of fibrotic markers for the development of diastolic dysfunction and long-term outcome in patients suffering an ST-elevated myocardial infarction (STEMI). We analyzed 236 patients from the GIPS-III cohort with available echocardiographic studies and plasma measurements at hospitalization and after 4 months follow-up. Adjusted logistic mixed effects modelling revealed no association between the occurrence of diastolic dysfunction over time with abnormal plasma levels of galectin-3 and ST2. We observed no differences regarding survival outcome at follow-up of 5 years between patients with normal versus abnormal values in both galectin-3 (P = 0.75), and ST2 (P = 0.85). In conclusion, galectin-3 and sST2 were not associated with the development of diastolic dysfunction in non-diabetic patients that presented with a STEMI.

AB - Galectin-3 and Suppression of tumorigenicity-2 (ST2) are known markers of cardiac fibrosis. We investigated the prognostic value of fibrotic markers for the development of diastolic dysfunction and long-term outcome in patients suffering an ST-elevated myocardial infarction (STEMI). We analyzed 236 patients from the GIPS-III cohort with available echocardiographic studies and plasma measurements at hospitalization and after 4 months follow-up. Adjusted logistic mixed effects modelling revealed no association between the occurrence of diastolic dysfunction over time with abnormal plasma levels of galectin-3 and ST2. We observed no differences regarding survival outcome at follow-up of 5 years between patients with normal versus abnormal values in both galectin-3 (P = 0.75), and ST2 (P = 0.85). In conclusion, galectin-3 and sST2 were not associated with the development of diastolic dysfunction in non-diabetic patients that presented with a STEMI.

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SN - 2045-2322

VL - 14

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 19122

ER -

Association of fibrotic markers with diastolic function after STEMI

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