TY - JOUR
T1 - Association of amyloid-beta with depression or depressive symptoms in older adults without dementia
T2 - a systematic review and meta-analysis
AU - Twait, Emma L.
AU - Wu, Jen Hao
AU - Kamarioti, Maria
AU - Basten, Maartje
AU - van der Flier, Wiesje M.
AU - Gerritsen, Lotte
AU - Geerlings, Mirjam I.
N1 - Publisher Copyright:
© 2024, The Author(s).
PY - 2024/1/15
Y1 - 2024/1/15
N2 - Several lines of evidence have indicated that depression might be a prodromal symptom of Alzheimer’s disease (AD). This systematic review and meta-analysis investigated the cross-sectional association between amyloid-beta, one of the key pathologies defining AD, and depression or depressive symptoms in older adults without dementia. A systematic search in PubMed yielded 689 peer-reviewed articles. After full-text screening, nine CSF studies, 11 PET studies, and five plasma studies were included. No association between amyloid-beta and depression or depressive symptoms were found using cerebrospinal fluid (CSF) (0.15; 95% CI: −0.08; 0.37), positron emission topography (PET) (Cohen’s d: 0.09; 95% CI: −0.05; 0.24), or plasma (−0.01; 95% CI: −0.23; 0.22). However, subgroup analyses revealed an association in plasma studies of individuals with cognitive impairment. A trend of an association was found in the studies using CSF and PET. This systematic review and meta-analysis suggested that depressive symptoms may be part of the prodromal stage of dementia.
AB - Several lines of evidence have indicated that depression might be a prodromal symptom of Alzheimer’s disease (AD). This systematic review and meta-analysis investigated the cross-sectional association between amyloid-beta, one of the key pathologies defining AD, and depression or depressive symptoms in older adults without dementia. A systematic search in PubMed yielded 689 peer-reviewed articles. After full-text screening, nine CSF studies, 11 PET studies, and five plasma studies were included. No association between amyloid-beta and depression or depressive symptoms were found using cerebrospinal fluid (CSF) (0.15; 95% CI: −0.08; 0.37), positron emission topography (PET) (Cohen’s d: 0.09; 95% CI: −0.05; 0.24), or plasma (−0.01; 95% CI: −0.23; 0.22). However, subgroup analyses revealed an association in plasma studies of individuals with cognitive impairment. A trend of an association was found in the studies using CSF and PET. This systematic review and meta-analysis suggested that depressive symptoms may be part of the prodromal stage of dementia.
KW - Aged
KW - Humans
KW - Amyloid beta-Peptides/cerebrospinal fluid
KW - Biomarkers
KW - Cognitive Dysfunction/diagnosis
KW - Cross-Sectional Studies
KW - Depression
KW - Positron-Emission Tomography
KW - tau Proteins/cerebrospinal fluid
UR - http://www.scopus.com/inward/record.url?scp=85182492171&partnerID=8YFLogxK
U2 - 10.1038/s41398-024-02739-9
DO - 10.1038/s41398-024-02739-9
M3 - Review article
C2 - 38225253
AN - SCOPUS:85182492171
SN - 2158-3188
VL - 14
JO - Translational Psychiatry
JF - Translational Psychiatry
IS - 1
M1 - 25
ER -