TY - JOUR
T1 - Association between cardiovascular risk factors and intracranial hemorrhage in patients with acute leukemia
AU - Cornelissen, Loes L
AU - Kreuger, Aukje L
AU - Caram-Deelder, Camila
AU - Huisman, Menno V
AU - Middelburg, Rutger A
AU - Kerkhoffs, Jean Louis H
AU - von dem Borne, Peter A
AU - Beckers, Erik A M
AU - de Vooght, Karen M K
AU - Kuball, Jürgen
AU - van der Bom, Johanna G
AU - Zwaginga, J J
N1 - Funding Information:
JK works at an institution that received a fee by Miltenyi, Novartis, Gadeta. JLK works at an institution that received a research grant from Terumo BCT. The other authors declare no conflicts of interest.
Publisher Copyright:
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
PY - 2022/4
Y1 - 2022/4
N2 - Background: Intracranial hemorrhage is seen more frequently in acute leukemia patients compared to the general population. Besides leukemia-related risk factors, also risk factors that are present in the general population might contribute to hemorrhagic complications in leukemia patients. Of those, cardiovascular risk factors leading to chronic vascular damage could modulate the occurrence of intracranial hemorrhage in these patients, as during their disease and treatment acute endothelial damage occurs due to factors like thrombocytopenia and inflammation. Objectives: Our aim was to explore if cardiovascular risk factors can predict intracranial hemorrhage in acute leukemia patients. Methods: In a case-control study nested in a cohort of acute leukemia patients, including 17 cases with intracranial hemorrhage and 55 matched control patients without intracranial hemorrhage, data on cardiovascular risk factors were collected for all patients. Analyses were performed via conditional logistic regression. Results: Pre-existing hypertension and ischemic heart disease in the medical history were associated with intracranial hemorrhage, with an incidence rate ratio of 12.9 (95% confidence interval [CI] 1.5 to 109.2) and 12.1 (95% CI 1.3 to110.7), respectively. Conclusion: Both pre-existing hypertension and ischemic heart disease seem to be strong predictors of an increased risk for intracranial hemorrhage in leukemia patients.
AB - Background: Intracranial hemorrhage is seen more frequently in acute leukemia patients compared to the general population. Besides leukemia-related risk factors, also risk factors that are present in the general population might contribute to hemorrhagic complications in leukemia patients. Of those, cardiovascular risk factors leading to chronic vascular damage could modulate the occurrence of intracranial hemorrhage in these patients, as during their disease and treatment acute endothelial damage occurs due to factors like thrombocytopenia and inflammation. Objectives: Our aim was to explore if cardiovascular risk factors can predict intracranial hemorrhage in acute leukemia patients. Methods: In a case-control study nested in a cohort of acute leukemia patients, including 17 cases with intracranial hemorrhage and 55 matched control patients without intracranial hemorrhage, data on cardiovascular risk factors were collected for all patients. Analyses were performed via conditional logistic regression. Results: Pre-existing hypertension and ischemic heart disease in the medical history were associated with intracranial hemorrhage, with an incidence rate ratio of 12.9 (95% confidence interval [CI] 1.5 to 109.2) and 12.1 (95% CI 1.3 to110.7), respectively. Conclusion: Both pre-existing hypertension and ischemic heart disease seem to be strong predictors of an increased risk for intracranial hemorrhage in leukemia patients.
KW - cardiovascular risk factors
KW - intracranial hemorrhage
KW - leukemia
UR - http://www.scopus.com/inward/record.url?scp=85122881521&partnerID=8YFLogxK
U2 - 10.1111/ejh.13737
DO - 10.1111/ejh.13737
M3 - Article
C2 - 34923665
SN - 0902-4441
VL - 108
SP - 310
EP - 318
JO - European Journal of Haematology
JF - European Journal of Haematology
IS - 4
ER -