Assessment of drug-induced immunotoxicity in animal models

Femke van Wijk; Stefan Nierkens

doi:10.1016/j.ddtec.2006.03.003

Assessment of drug-induced immunotoxicity in animal models

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

With the growing understanding that drugs might induce immune-mediated adverse reactions in patients, immunotoxicity testing of new pharmaceuticals has become an important topic in drug development. The nonclinical assessment of unexpected immune suppression is based on relatively well-standardized and validated assays and animal models. For the evaluation of direct immune stimulation few animal models are available, whilst the development of animal models to assess drug-induced hypersensitivity and in particular autoimmunity is in its infancy.:

Original language	English
Pages (from-to)	103-9
Number of pages	7
Journal	Drug discovery today. Technologies
Volume	3
Issue number	1
DOIs	https://doi.org/10.1016/j.ddtec.2006.03.003
Publication status	Published - 2006

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10.1016/j.ddtec.2006.03.003

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title = "Assessment of drug-induced immunotoxicity in animal models",

abstract = "With the growing understanding that drugs might induce immune-mediated adverse reactions in patients, immunotoxicity testing of new pharmaceuticals has become an important topic in drug development. The nonclinical assessment of unexpected immune suppression is based on relatively well-standardized and validated assays and animal models. For the evaluation of direct immune stimulation few animal models are available, whilst the development of animal models to assess drug-induced hypersensitivity and in particular autoimmunity is in its infancy.:",

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AU - Nierkens, Stefan

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AB - With the growing understanding that drugs might induce immune-mediated adverse reactions in patients, immunotoxicity testing of new pharmaceuticals has become an important topic in drug development. The nonclinical assessment of unexpected immune suppression is based on relatively well-standardized and validated assays and animal models. For the evaluation of direct immune stimulation few animal models are available, whilst the development of animal models to assess drug-induced hypersensitivity and in particular autoimmunity is in its infancy.:

U2 - 10.1016/j.ddtec.2006.03.003

DO - 10.1016/j.ddtec.2006.03.003

M3 - Article

C2 - 24980108

SN - 1740-6749

VL - 3

SP - 103

EP - 109

JO - Drug discovery today. Technologies

JF - Drug discovery today. Technologies

IS - 1

ER -

Assessment of drug-induced immunotoxicity in animal models

Abstract

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