Assessing risk of bias and applicability

Johannes B. Reitsma; Anne W. Rutjes; Penny Whiting; Bada Yang; Mariska M. Leeflang; Patrick M. Bossuyt; Jonathan J. Deeks

doi:10.1002/9781119756194.ch8

Assessing risk of bias and applicability

Johannes B. Reitsma^*, Anne W. Rutjes, Penny Whiting, Bada Yang, Mariska M. Leeflang, Patrick M. Bossuyt, Jonathan J. Deeks

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Abstract

The findings of the assessment of risk of bias and applicability play an important role in the systematic review process, in particular in the analysis and interpretation of results. This chapter focuses on assessing risk of bias and applicability for individual studies in a review. It also provides guidance on assessing comparative accuracy studies. A large number of methodological quality assessment tools are available for test accuracy studies. Because of the lack of a universal tool that can be used for test accuracy studies across all clinical domains and types of index tests, an initiative was started to develop a generic tool named QUADAS. QUADAS-2 is a revision of the original QUADAS tool. QUADAS-2 assesses the risk of bias of a study across four domains: participant selection, index test, reference standard, and flow and timing, as well as an overall assessment of risk of bias.

Original language	English
Title of host publication	Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy
Editors	J.J. Deeks, P.M. Bossuyt, M.M. Leeflang, Y. Takwoingi
Publisher	John Wiley & Sons Inc.
Chapter	8
Pages	169-201
Number of pages	33
ISBN (Electronic)	9781119756187
ISBN (Print)	9781119756163
DOIs	https://doi.org/10.1002/9781119756194.ch8
Publication status	Published - 16 Jun 2023

Keywords

Applicability judgements
Comparative accuracy studies
Index test
Participant selection
QUADAS-2 tool
Quality assessment tools
Reference standard
Risk of bias
Test accuracy studies

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10.1002/9781119756194.ch8

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Reitsma, J. B., Rutjes, A. W., Whiting, P., Yang, B., Leeflang, M. M., Bossuyt, P. M., & Deeks, J. J. (2023). Assessing risk of bias and applicability. In J. J. Deeks, P. M. Bossuyt, M. M. Leeflang, & Y. Takwoingi (Eds.), Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy (pp. 169-201). John Wiley & Sons Inc.. https://doi.org/10.1002/9781119756194.ch8

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author = "Reitsma, {Johannes B.} and Rutjes, {Anne W.} and Penny Whiting and Bada Yang and Leeflang, {Mariska M.} and Bossuyt, {Patrick M.} and Deeks, {Jonathan J.}",

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Assessing risk of bias and applicability. / Reitsma, Johannes B.; Rutjes, Anne W.; Whiting, Penny et al.
Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy. ed. / J.J. Deeks; P.M. Bossuyt; M.M. Leeflang; Y. Takwoingi. John Wiley & Sons Inc., 2023. p. 169-201.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

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Assessing risk of bias and applicability

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Keywords

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