Assessing and minimizing the risk of cerebrospinal fluid leakage after intradural surgery

Ahmet Kinaci

doi:10.33540/2330

Assessing and minimizing the risk of cerebrospinal fluid leakage after intradural surgery

Ahmet Kinaci

Neurochirurgen

Research output: Thesis › Doctoral thesis 2 (Research NOT UU / Graduation UU)

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Abstract

This thesis evaluated the effectiveness of current sealants in preventing incisional CSF leakage. Subsequently, we developed a new dural sealant patch (Liqoseal) which should ultimately prevent incisional CSF leakage in patients. However, before clinical application, the effectiveness and the safety of this sealant in preclinical studies had to be evaluated. In this thesis the in vitro effectiveness and in vivo safety of Liqoseal have been studied.

Original language	English
Awarding Institution	University Medical Center (UMC) Utrecht
Supervisors/Advisors	van der Zwan, Bart, Supervisor van Doormaal, Tristan, Co-supervisor
Award date	28 Jan 2025
Publisher	Utrecht University
Print ISBNs	978-94-6506-795-7
DOIs	https://doi.org/10.33540/2330
Publication status	Published - 28 Jan 2025

Keywords

Cerebrospinal fluid leakage
intradural surgery
cranial surgery
spinal surgery
sealant
in vitro study
in vivo study

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title = "Assessing and minimizing the risk of cerebrospinal fluid leakage after intradural surgery",

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AB - This thesis evaluated the effectiveness of current sealants in preventing incisional CSF leakage. Subsequently, we developed a new dural sealant patch (Liqoseal) which should ultimately prevent incisional CSF leakage in patients. However, before clinical application, the effectiveness and the safety of this sealant in preclinical studies had to be evaluated. In this thesis the in vitro effectiveness and in vivo safety of Liqoseal have been studied.

KW - Cerebrospinal fluid leakage

KW - intradural surgery

KW - cranial surgery

KW - spinal surgery

KW - sealant

KW - in vitro study

KW - in vivo study

U2 - 10.33540/2330

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SN - 978-94-6506-795-7

PB - Utrecht University

ER -

Assessing and minimizing the risk of cerebrospinal fluid leakage after intradural surgery

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Keywords

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