Abstract
Recent progress in molecular medicine has provided important tools to identify antigen-specific T cells. In most cases, the approach is based on oligomeric combinations of recombinant major histocompatibility complex-peptide complexes fixed to various rigid supports available for binding by the T-cell receptor1-8. These tools have greatly increased our insight into mechanisms of immune responses mediated by CD8+ T cells1,2. Examples of the diverse fields of application for this technology include immunization, viral infections and oral tolerance induction1-6.
Original language | English |
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Pages (from-to) | 1406-1410 |
Number of pages | 5 |
Journal | Nature Medicine |
Volume | 6 |
Issue number | 12 |
DOIs | |
Publication status | Published - 1 Dec 2000 |