Artificial antigen-presenting cells as a tool to exploit the immune 'synapse'

Berent Prakken, Marca Wauben, Davide Genini, Rodrigo Samodal, Joellen Barnett, Alberto Mendivil, Lorenzo Leoni, Salvatore Albani*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

85 Citations (Scopus)

Abstract

Recent progress in molecular medicine has provided important tools to identify antigen-specific T cells. In most cases, the approach is based on oligomeric combinations of recombinant major histocompatibility complex-peptide complexes fixed to various rigid supports available for binding by the T-cell receptor1-8. These tools have greatly increased our insight into mechanisms of immune responses mediated by CD8+ T cells1,2. Examples of the diverse fields of application for this technology include immunization, viral infections and oral tolerance induction1-6.

Original languageEnglish
Pages (from-to)1406-1410
Number of pages5
JournalNature Medicine
Volume6
Issue number12
DOIs
Publication statusPublished - 1 Dec 2000

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