TY - JOUR
T1 - Arrhythmic risk stratification in arrhythmogenic right ventricular cardiomyopathy
AU - Gasperetti, Alessio
AU - James, Cynthia A
AU - Carrick, Richard T
AU - Protonotarios, Alexandros
AU - Te Riele, Anneline S J M
AU - Cadrin-Tourigny, Julia
AU - Compagnucci, Paolo
AU - Duru, Firat
AU - van Tintelen, Peter
AU - Elliot, Perry M
AU - Calkins, Hugh
N1 - Publisher Copyright:
© 2023 The Author(s). Published by Oxford University Press on behalf of the European Society of Cardiology.
PY - 2023/11/1
Y1 - 2023/11/1
N2 - Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heritable cardiomyopathy characterized by a predominantly arrhythmic presentation. It represents the leading cause of sudden cardiac death (SCD) among athletes and poses a significant morbidity threat in the general population. As a causative treatment for ARVC is still not available, the placement of an implantable cardioverter defibrillator represents the current cornerstone for SCD prevention in this setting. Thanks to international ARVC-dedicated efforts, significant steps have been achieved in recent years towards an individualized, patient-centred risk stratification approach. A novel risk calculator algorithm estimating the 5-year risk of arrhythmias of patients with ARVC has been introduced in clinical practice and subsequently validated. The purpose of this article is to summarize the body of evidence that has allowed the development of this tool and to discuss the best way to implement its use in the care of an individual patient.
AB - Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heritable cardiomyopathy characterized by a predominantly arrhythmic presentation. It represents the leading cause of sudden cardiac death (SCD) among athletes and poses a significant morbidity threat in the general population. As a causative treatment for ARVC is still not available, the placement of an implantable cardioverter defibrillator represents the current cornerstone for SCD prevention in this setting. Thanks to international ARVC-dedicated efforts, significant steps have been achieved in recent years towards an individualized, patient-centred risk stratification approach. A novel risk calculator algorithm estimating the 5-year risk of arrhythmias of patients with ARVC has been introduced in clinical practice and subsequently validated. The purpose of this article is to summarize the body of evidence that has allowed the development of this tool and to discuss the best way to implement its use in the care of an individual patient.
KW - Arrhythmias, Cardiac/diagnosis
KW - Arrhythmogenic Right Ventricular Dysplasia/complications
KW - Death, Sudden, Cardiac/etiology
KW - Defibrillators, Implantable/adverse effects
KW - Humans
KW - Risk Assessment
KW - Risk Factors
KW - Primary Prevention
KW - Arrhythmogenic right ventricular cardiomyopathy
KW - Risk stratification
KW - ICD
UR - http://www.scopus.com/inward/record.url?scp=85178499095&partnerID=8YFLogxK
U2 - 10.1093/europace/euad312
DO - 10.1093/europace/euad312
M3 - Review article
C2 - 37935403
SN - 1099-5129
VL - 25
JO - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
JF - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
IS - 11
M1 - euad312
ER -