Arrhythmic mitral valve prolapse: Introducing an era of multimodality imaging-based diagnosis and risk stratification

Deni Kukavica, Marco Guglielmo, Andrea Baggiano, Giuseppe Muscogiuri, Laura Fusini, Manuela Muratori, Gloria Tamborini, Valentina Mantegazza, Alessandro Trancuccio, Carlo Arnò, Andrea Mazzanti, Mauro Pepi, Silvia Giuliana Priori, Gianluca Pontone*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Mitral valve prolapse is a common cardiac condition, with an estimated prevalence between 1% and 3%. Most patients have a benign course, but ever since its initial description mitral valve prolapse has been associated to sudden cardiac death. Although the causal relationship between mitral valve prolapse and sudden cardiac death has never been clearly demonstrated, different factors have been implicated in arrhythmogenesis in patients with mitral valve prolapse. In this work, we offer a comprehensive overview of the etiology and the genetic background, epidemiology, pathophysiology, and we focus on the state-of-the-art imaging-based diagnosis of mitral valve prolapse. Going beyond the classical, well-described clinical factors, such as young age, female gender and auscultatory findings, we investigate multimodality imaging features, such as alterations of anatomy and function of the mitral valve and its leaflets, the structural and contractile anomalies of the myocardium, all of which have been associated to sudden cardiac death.

Original languageEnglish
Article number467
JournalDiagnostics
Volume11
Issue number3
DOIs
Publication statusPublished - Mar 2021
Externally publishedYes

Keywords

  • Arrhythmia
  • Cardiovascular magnetic resonance
  • Echocardiography
  • Mitral valve prolapse
  • Multimodality imaging
  • Risk factors
  • Sudden cardiac death

Fingerprint

Dive into the research topics of 'Arrhythmic mitral valve prolapse: Introducing an era of multimodality imaging-based diagnosis and risk stratification'. Together they form a unique fingerprint.

Cite this