Are renal ciliopathies (replication) stressed out?

Gisela G Slaats; R Giles

doi:10.1016/j.tcb.2015.03.005

Are renal ciliopathies (replication) stressed out?

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Juvenile renal failure is commonly caused by the ciliopathy nephronophthisis (NPHP). Since all NPHP genes regulate cilia function, it has been assumed that NPHP onset is due to cilia loss. However, recent data suggest that DNA damage caused by replication stress, possibly concomitant with or upstream of cilia dysfunction, causes NPHP.

Original language	English
Pages (from-to)	317-9
Number of pages	3
Journal	Trends in Cell Biology
Volume	25
Issue number	6
DOIs	https://doi.org/10.1016/j.tcb.2015.03.005
Publication status	Published - Jun 2015

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10.1016/j.tcb.2015.03.005

Cite this

@article{447f519fa02f4d68adf3b4877c1d98ef,

title = "Are renal ciliopathies (replication) stressed out?",

abstract = "Juvenile renal failure is commonly caused by the ciliopathy nephronophthisis (NPHP). Since all NPHP genes regulate cilia function, it has been assumed that NPHP onset is due to cilia loss. However, recent data suggest that DNA damage caused by replication stress, possibly concomitant with or upstream of cilia dysfunction, causes NPHP.",

author = "Slaats, {Gisela G} and R Giles",

year = "2015",

month = jun,

doi = "10.1016/j.tcb.2015.03.005",

language = "English",

volume = "25",

pages = "317--9",

journal = "Trends in Cell Biology",

issn = "0962-8924",