Approaches to microRNA discovery

Eugene Berezikov; Edwin Cuppen; Ronald H.A. Plasterk

doi:10.1038/ng1794

Approaches to microRNA discovery

Eugene Berezikov^*, Edwin Cuppen, Ronald H.A. Plasterk

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

308 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are noncoding RNAs that can regulate gene expression. Several hundred genes encoding miRNAs have been experimentally identified in animals, and many more are predicted by computational methods. How can new miRNAs be discovered and distinguished from other types of small RNA? Here we summarize current methods for identifying and validating miRNAs and discuss criteria used to define an miRNA.

Original language	English
Journal	Nature Genetics
Volume	38
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1038/ng1794
Publication status	Published - 1 Jun 2006

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10.1038/ng1794

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title = "Approaches to microRNA discovery",

abstract = "MicroRNAs (miRNAs) are noncoding RNAs that can regulate gene expression. Several hundred genes encoding miRNAs have been experimentally identified in animals, and many more are predicted by computational methods. How can new miRNAs be discovered and distinguished from other types of small RNA? Here we summarize current methods for identifying and validating miRNAs and discuss criteria used to define an miRNA.",

author = "Eugene Berezikov and Edwin Cuppen and Plasterk, \{Ronald H.A.\}",

year = "2006",

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T1 - Approaches to microRNA discovery

AU - Berezikov, Eugene

AU - Cuppen, Edwin

AU - Plasterk, Ronald H.A.

PY - 2006/6/1

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N2 - MicroRNAs (miRNAs) are noncoding RNAs that can regulate gene expression. Several hundred genes encoding miRNAs have been experimentally identified in animals, and many more are predicted by computational methods. How can new miRNAs be discovered and distinguished from other types of small RNA? Here we summarize current methods for identifying and validating miRNAs and discuss criteria used to define an miRNA.

AB - MicroRNAs (miRNAs) are noncoding RNAs that can regulate gene expression. Several hundred genes encoding miRNAs have been experimentally identified in animals, and many more are predicted by computational methods. How can new miRNAs be discovered and distinguished from other types of small RNA? Here we summarize current methods for identifying and validating miRNAs and discuss criteria used to define an miRNA.

UR - https://www.scopus.com/pages/publications/33745239258

U2 - 10.1038/ng1794

DO - 10.1038/ng1794

M3 - Review article

C2 - 16736019

AN - SCOPUS:33745239258

SN - 1061-4036

VL - 38

JO - Nature Genetics

JF - Nature Genetics

IS - SUPPL. 1

ER -

Approaches to microRNA discovery

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