Abstract
Radioreceptor assays can be a useful tool for systematic toxicological analysis in that they can be applied for the detection of an entire pharmacological class of drugs. In the present paper procedures for radioreceptor assays for benzodiazepines, anticholinergics and antihistaminics have been described in detail. The development of the assay for antihistaminics in urine is given in order to illustrate the prerequisites for these types of assays with regard to the incubation conditions. In part 2 the applicability of the three assays for systematic toxicological analysis will be evaluated on the basis of testing a large number of urine samples after administration of a selected number of drugs to healthy volunteers and patients.
Original language | English |
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Pages (from-to) | 53-8 |
Number of pages | 6 |
Journal | Journal of Pharmaceutical and Biomedical Analysis |
Volume | 12 |
Issue number | 1 |
Publication status | Published - Jan 1994 |
Keywords
- Animals
- Benzodiazepines
- Binding Sites
- False Positive Reactions
- Histamine Antagonists
- Histamine H1 Antagonists
- Histamine H2 Antagonists
- Humans
- Parasympatholytics
- Radioligand Assay
- Toxicology