Application of Antigen Cross-Presentation Research into Patient Care

ML Boes (Editor)

Research output: Book/ReportBook editingAcademicpeer-review

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The activation of adaptive immune responses requires the processing and presentation of protein antigens to lymphocytes. Especially dendritic cells are effective at display of antigen-derived peptides in the form of immunogenic peptide/MHC complexes to CD4 and CD8-positive T cells, and can stimulate even naive T cells to clonally expand. During the last 40 years, mechanisms that facilitate antigen processing and presentation were clarified, mostly from work in cell lines and mouse models. From mouse-based work, it is now clear that dendritic cells represent a collection of specialized cell subsets that are particularly well endowed to stimulate antigen transport to distinct tissue locations, to transfer antigens between cellular subsets or to trigger T cell responses. Dendritic cell subsets hold great promise for therapeutic application, for example as dendritic cell-based vaccines to bolster immune responses against viruses or malignant growths. Hurdles remain that preclude the efficient application of high quality pre-clinical research into standardized patient care. In this research topic, efforts in dendritic cell research and dendritic cell-based vaccines are discussed, from both pre-clinical and application points of view.
Original languageEnglish
PublisherFrontiers Media S. A.
ISBN (Electronic)978-2-88945-191-3
Publication statusPublished - May 2017

Publication series

NameFrontiers Research Topic Ebook
ISSN (Electronic)1664-8714


  • Antigen cross-presentation
  • dendritic cells
  • Patient Care
  • Vaccination
  • Immunotherapy
  • clinical translation
  • cross-presentation


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