Apolipoprotein e and LRP1 increase early in Parkinson's disease pathogenesis

Micha M.M. Wilhelmus; John G.J.M. Bol; Elise S. Van Haastert; Annemieke J.M. Rozemuller; Guojun Bu; Benjamin Drukarch; Jeroen J.M. Hoozemans

doi:10.1016/j.ajpath.2011.07.021

Apolipoprotein e and LRP1 increase early in Parkinson's disease pathogenesis

Micha M.M. Wilhelmus^*, John G.J.M. Bol, Elise S. Van Haastert, Annemieke J.M. Rozemuller, Guojun Bu, Benjamin Drukarch, Jeroen J.M. Hoozemans

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

14 Citations (Scopus)

Abstract

Parkinson's disease (PD) is characterized by α-synucleincontaining Lewy bodies (LBs) and loss of melanized neurons in the substantia nigra (SN). Recently, a link between apolipoprotein E (ApoE) expression, α-synuclein aggregation, and neurodegeneration was suggested. Here, we report on ApoE expression appearing in melanized neurons of the SN and in LBs in both PD and incidental LB disease cases. Interestingly, increased expression of the low-density lipoprotein receptor-related protein 1 (the receptor for ApoE) was also observed in incidental LB disease and PD. Our data suggest that alterations in lipoprotein homeostasis/signaling in melanized neurons of the SN are an early event during PD pathogenesis.

Original language	English
Pages (from-to)	2152-2156
Number of pages	5
Journal	American Journal of Pathology
Volume	179
Issue number	5
DOIs	https://doi.org/10.1016/j.ajpath.2011.07.021
Publication status	Published - 1 Nov 2011
Externally published	Yes

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title = "Apolipoprotein e and LRP1 increase early in Parkinson's disease pathogenesis",

abstract = "Parkinson's disease (PD) is characterized by α-synucleincontaining Lewy bodies (LBs) and loss of melanized neurons in the substantia nigra (SN). Recently, a link between apolipoprotein E (ApoE) expression, α-synuclein aggregation, and neurodegeneration was suggested. Here, we report on ApoE expression appearing in melanized neurons of the SN and in LBs in both PD and incidental LB disease cases. Interestingly, increased expression of the low-density lipoprotein receptor-related protein 1 (the receptor for ApoE) was also observed in incidental LB disease and PD. Our data suggest that alterations in lipoprotein homeostasis/signaling in melanized neurons of the SN are an early event during PD pathogenesis.",

author = "Wilhelmus, {Micha M.M.} and Bol, {John G.J.M.} and {Van Haastert}, {Elise S.} and Rozemuller, {Annemieke J.M.} and Guojun Bu and Benjamin Drukarch and Hoozemans, {Jeroen J.M.}",

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TY - JOUR

T1 - Apolipoprotein e and LRP1 increase early in Parkinson's disease pathogenesis

AU - Wilhelmus, Micha M.M.

AU - Bol, John G.J.M.

AU - Van Haastert, Elise S.

AU - Rozemuller, Annemieke J.M.

AU - Bu, Guojun

AU - Drukarch, Benjamin

AU - Hoozemans, Jeroen J.M.

PY - 2011/11/1

Y1 - 2011/11/1

N2 - Parkinson's disease (PD) is characterized by α-synucleincontaining Lewy bodies (LBs) and loss of melanized neurons in the substantia nigra (SN). Recently, a link between apolipoprotein E (ApoE) expression, α-synuclein aggregation, and neurodegeneration was suggested. Here, we report on ApoE expression appearing in melanized neurons of the SN and in LBs in both PD and incidental LB disease cases. Interestingly, increased expression of the low-density lipoprotein receptor-related protein 1 (the receptor for ApoE) was also observed in incidental LB disease and PD. Our data suggest that alterations in lipoprotein homeostasis/signaling in melanized neurons of the SN are an early event during PD pathogenesis.

AB - Parkinson's disease (PD) is characterized by α-synucleincontaining Lewy bodies (LBs) and loss of melanized neurons in the substantia nigra (SN). Recently, a link between apolipoprotein E (ApoE) expression, α-synuclein aggregation, and neurodegeneration was suggested. Here, we report on ApoE expression appearing in melanized neurons of the SN and in LBs in both PD and incidental LB disease cases. Interestingly, increased expression of the low-density lipoprotein receptor-related protein 1 (the receptor for ApoE) was also observed in incidental LB disease and PD. Our data suggest that alterations in lipoprotein homeostasis/signaling in melanized neurons of the SN are an early event during PD pathogenesis.

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U2 - 10.1016/j.ajpath.2011.07.021

DO - 10.1016/j.ajpath.2011.07.021

M3 - Article

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VL - 179

SP - 2152

EP - 2156

JO - American Journal of Pathology

JF - American Journal of Pathology

IS - 5

ER -

Apolipoprotein e and LRP1 increase early in Parkinson's disease pathogenesis

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