Antipsychotic prophylaxis is needed after remission from a first psychotic episode in schizophrenia patients: results from an aborted randomised trial

G. Boonstra; H. Burger; D.E. Grobbee; R.S. Kahn

doi:10.3109/13651501.2010.534801

Antipsychotic prophylaxis is needed after remission from a first psychotic episode in schizophrenia patients: results from an aborted randomised trial

G. Boonstra, H. Burger, D.E. Grobbee, R.S. Kahn

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: To assess the effect of withdrawal of antipsychotic treatment on relapse risk in remitted first-episode schizophrenia patients.

METHODS: First-episode 1-year stable and remitted outpatients with a schizophrenic disorder were randomly allocated to continuation of their antipsychotic regimen for at least 6 months (N = 9), or gradual withdrawal (N = 11). Primary outcome was the difference in cumulative relapse-free survival at 9 months.

RESULTS: Recruitment was terminated prematurely on 26 October 2005. The cumulative relapse-free survival was 88% (SE = 0.12) in the continuation and 18% (SE = 0.12) in the discontinuation group (P = 0.001) at 9 months follow-up.

CONCLUSIONS: Discontinuation of antipsychotic medication markedly increases the risk of relapse in stable remitted first-episode schizophrenia patients. In future studies the topics of safety monitoring and sampling of patients should receive extra attention.

Original language	English
Pages (from-to)	128-134
Number of pages	7
Journal	International Journal of Psychiatry in Clinical Practice
Volume	15
Issue number	2
DOIs	https://doi.org/10.3109/13651501.2010.534801
Publication status	Published - Jun 2011

Keywords

Adult
Antipsychotic Agents
Disease-Free Survival
Female
Follow-Up Studies
Humans
Male
Middle Aged
Schizophrenia
Secondary Prevention
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

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10.3109/13651501.2010.534801

http://www.ncbi.nlm.nih.gov/pubmed/22121861

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title = "Antipsychotic prophylaxis is needed after remission from a first psychotic episode in schizophrenia patients: results from an aborted randomised trial",

abstract = "OBJECTIVE: To assess the effect of withdrawal of antipsychotic treatment on relapse risk in remitted first-episode schizophrenia patients.METHODS: First-episode 1-year stable and remitted outpatients with a schizophrenic disorder were randomly allocated to continuation of their antipsychotic regimen for at least 6 months (N = 9), or gradual withdrawal (N = 11). Primary outcome was the difference in cumulative relapse-free survival at 9 months.RESULTS: Recruitment was terminated prematurely on 26 October 2005. The cumulative relapse-free survival was 88% (SE = 0.12) in the continuation and 18% (SE = 0.12) in the discontinuation group (P = 0.001) at 9 months follow-up.CONCLUSIONS: Discontinuation of antipsychotic medication markedly increases the risk of relapse in stable remitted first-episode schizophrenia patients. In future studies the topics of safety monitoring and sampling of patients should receive extra attention.",

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author = "G. Boonstra and H. Burger and D.E. Grobbee and R.S. Kahn",

year = "2011",

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doi = "10.3109/13651501.2010.534801",

language = "English",

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Antipsychotic prophylaxis is needed after remission from a first psychotic episode in schizophrenia patients: results from an aborted randomised trial. / Boonstra, G.; Burger, H.; Grobbee, D.E. et al.
In: International Journal of Psychiatry in Clinical Practice, Vol. 15, No. 2, 06.2011, p. 128-134.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - Antipsychotic prophylaxis is needed after remission from a first psychotic episode in schizophrenia patients

T2 - results from an aborted randomised trial

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AU - Burger, H.

AU - Grobbee, D.E.

AU - Kahn, R.S.

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N2 - OBJECTIVE: To assess the effect of withdrawal of antipsychotic treatment on relapse risk in remitted first-episode schizophrenia patients.METHODS: First-episode 1-year stable and remitted outpatients with a schizophrenic disorder were randomly allocated to continuation of their antipsychotic regimen for at least 6 months (N = 9), or gradual withdrawal (N = 11). Primary outcome was the difference in cumulative relapse-free survival at 9 months.RESULTS: Recruitment was terminated prematurely on 26 October 2005. The cumulative relapse-free survival was 88% (SE = 0.12) in the continuation and 18% (SE = 0.12) in the discontinuation group (P = 0.001) at 9 months follow-up.CONCLUSIONS: Discontinuation of antipsychotic medication markedly increases the risk of relapse in stable remitted first-episode schizophrenia patients. In future studies the topics of safety monitoring and sampling of patients should receive extra attention.

AB - OBJECTIVE: To assess the effect of withdrawal of antipsychotic treatment on relapse risk in remitted first-episode schizophrenia patients.METHODS: First-episode 1-year stable and remitted outpatients with a schizophrenic disorder were randomly allocated to continuation of their antipsychotic regimen for at least 6 months (N = 9), or gradual withdrawal (N = 11). Primary outcome was the difference in cumulative relapse-free survival at 9 months.RESULTS: Recruitment was terminated prematurely on 26 October 2005. The cumulative relapse-free survival was 88% (SE = 0.12) in the continuation and 18% (SE = 0.12) in the discontinuation group (P = 0.001) at 9 months follow-up.CONCLUSIONS: Discontinuation of antipsychotic medication markedly increases the risk of relapse in stable remitted first-episode schizophrenia patients. In future studies the topics of safety monitoring and sampling of patients should receive extra attention.

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KW - Randomized Controlled Trial

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ER -

Antipsychotic prophylaxis is needed after remission from a first psychotic episode in schizophrenia patients: results from an aborted randomised trial

Abstract

Keywords

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