Antiphospholipid syndrome: State of the art on clinical practice guidelines

Marteen Limper; Carlo Alberto Scirè; Rosaria Talarico; Zahir Amoura; Tadej Avcin; Martina Basile; Gerd Burmester; Linda Carli; Ricard Cervera; Nathalie Costedoat-Chalumeau; Andrea Doria; Thomas Dörner; João Eurico Fonseca; Ilaria Galetti; Eric Hachulla; David Launay; Filipa Lourenco; Carla Macieira; Pierluigi Meroni; Carlo Maurizio Montecucco; Maria Francisca Moraes-Fontes; Luc Mouthon; Cecilia Nalli; Veronique Ramoni; Maria Tektonidou; Jacob M. Van Laar; Stefano Bombardieri; Matthias Schneider; Vanessa Smith; Ana Vieira; Maurizio Cutolo; Marta Mosca; Angela Tincani

doi:10.1136/rmdopen-2018-000785

Antiphospholipid syndrome: State of the art on clinical practice guidelines

Marteen Limper, Carlo Alberto Scirè, Rosaria Talarico, Zahir Amoura, Tadej Avcin, Martina Basile, Gerd Burmester, Linda Carli, Ricard Cervera, Nathalie Costedoat-Chalumeau, Andrea Doria, Thomas Dörner, João Eurico Fonseca, Ilaria Galetti, Eric Hachulla, David Launay, Filipa Lourenco, Carla Macieira, Pierluigi Meroni, Carlo Maurizio MontecuccoMaria Francisca Moraes-Fontes, Luc Mouthon, Cecilia Nalli, Veronique Ramoni, Maria Tektonidou, Jacob M. Van Laar, Stefano Bombardieri, Matthias Schneider, Vanessa Smith, Ana Vieira, Maurizio Cutolo, Marta Mosca, Angela Tincani^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

20 Citations (Scopus)

Abstract

Antiphospholipid syndrome (APS) is a rare disease characterised by venous and/or arterial thrombosis, pregnancy complications and the presence of specific autoantibodies called antiphospholipid antibodies. This review aims to identify existing clinical practice guidelines (CPG) as part of the ERN ReCONNET project, aimed at evaluating existing CPGs or recommendations in rare and complex diseases. Seventeen papers providing important data were identified; however, the literature search highlighted the scarceness of reliable clinical data to develop CPGs. With no formal clinical guidelines in place, diagnosis and treatment of APS is largely based on consensus and expert opinion. Patients' unmet need refers to the understanding of the disease and its clinical picture and implications, the need of education for patients, family members and healthcare providers, as well as to the development of monitoring pathways involving multiple healthcare providers.

Original language	English
Article number	e000785
Journal	RMD Open
Volume	4
Issue number	Suppl 1
DOIs	https://doi.org/10.1136/rmdopen-2018-000785 https://doi.org/10.1136/rmdopen-2018-000785
Publication status	Published - 1 Oct 2018

Keywords

antiphospholipid syndrome
clinical practice guidelines
ERN ReCONNET
European reference networks
unmet needs

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Limper, M., Scirè, C. A., Talarico, R., Amoura, Z., Avcin, T., Basile, M., Burmester, G., Carli, L., Cervera, R., Costedoat-Chalumeau, N., Doria, A., Dörner, T., Fonseca, J. E., Galetti, I., Hachulla, E., Launay, D., Lourenco, F., Macieira, C., Meroni, P., ... Tincani, A. (2018). Antiphospholipid syndrome: State of the art on clinical practice guidelines. RMD Open, 4(Suppl 1), Article e000785. https://doi.org/10.1136/rmdopen-2018-000785, https://doi.org/10.1136/rmdopen-2018-000785

@article{de32b92aea1749138e9c42799e407bb9,

title = "Antiphospholipid syndrome: State of the art on clinical practice guidelines",

abstract = "Antiphospholipid syndrome (APS) is a rare disease characterised by venous and/or arterial thrombosis, pregnancy complications and the presence of specific autoantibodies called antiphospholipid antibodies. This review aims to identify existing clinical practice guidelines (CPG) as part of the ERN ReCONNET project, aimed at evaluating existing CPGs or recommendations in rare and complex diseases. Seventeen papers providing important data were identified; however, the literature search highlighted the scarceness of reliable clinical data to develop CPGs. With no formal clinical guidelines in place, diagnosis and treatment of APS is largely based on consensus and expert opinion. Patients' unmet need refers to the understanding of the disease and its clinical picture and implications, the need of education for patients, family members and healthcare providers, as well as to the development of monitoring pathways involving multiple healthcare providers.",

keywords = "antiphospholipid syndrome, clinical practice guidelines, ERN ReCONNET, European reference networks, unmet needs",

author = "Marteen Limper and Scir{\`e}, \{Carlo Alberto\} and Rosaria Talarico and Zahir Amoura and Tadej Avcin and Martina Basile and Gerd Burmester and Linda Carli and Ricard Cervera and Nathalie Costedoat-Chalumeau and Andrea Doria and Thomas D{\"o}rner and Fonseca, \{Jo{\~a}o Eurico\} and Ilaria Galetti and Eric Hachulla and David Launay and Filipa Lourenco and Carla Macieira and Pierluigi Meroni and Montecucco, \{Carlo Maurizio\} and Moraes-Fontes, \{Maria Francisca\} and Luc Mouthon and Cecilia Nalli and Veronique Ramoni and Maria Tektonidou and \{Van Laar\}, \{Jacob M.\} and Stefano Bombardieri and Matthias Schneider and Vanessa Smith and Ana Vieira and Maurizio Cutolo and Marta Mosca and Angela Tincani",

note = "Publisher Copyright: {\textcopyright} 2018 Author(s) (or their employer(s)).",

year = "2018",

month = oct,

day = "1",

doi = "10.1136/rmdopen-2018-000785",

language = "English",

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Limper, M, Scirè, CA, Talarico, R, Amoura, Z, Avcin, T, Basile, M, Burmester, G, Carli, L, Cervera, R, Costedoat-Chalumeau, N, Doria, A, Dörner, T, Fonseca, JE, Galetti, I, Hachulla, E, Launay, D, Lourenco, F, Macieira, C, Meroni, P, Montecucco, CM, Moraes-Fontes, MF, Mouthon, L, Nalli, C, Ramoni, V, Tektonidou, M, Van Laar, JM, Bombardieri, S, Schneider, M, Smith, V, Vieira, A, Cutolo, M, Mosca, M & Tincani, A 2018, 'Antiphospholipid syndrome: State of the art on clinical practice guidelines', RMD Open, vol. 4, no. Suppl 1, e000785. https://doi.org/10.1136/rmdopen-2018-000785, https://doi.org/10.1136/rmdopen-2018-000785

TY - JOUR

T1 - Antiphospholipid syndrome

T2 - State of the art on clinical practice guidelines

AU - Limper, Marteen

AU - Scirè, Carlo Alberto

AU - Talarico, Rosaria

AU - Amoura, Zahir

AU - Avcin, Tadej

AU - Basile, Martina

AU - Burmester, Gerd

AU - Carli, Linda

AU - Cervera, Ricard

AU - Costedoat-Chalumeau, Nathalie

AU - Doria, Andrea

AU - Dörner, Thomas

AU - Fonseca, João Eurico

AU - Galetti, Ilaria

AU - Hachulla, Eric

AU - Launay, David

AU - Lourenco, Filipa

AU - Macieira, Carla

AU - Meroni, Pierluigi

AU - Montecucco, Carlo Maurizio

AU - Moraes-Fontes, Maria Francisca

AU - Mouthon, Luc

AU - Nalli, Cecilia

AU - Ramoni, Veronique

AU - Tektonidou, Maria

AU - Van Laar, Jacob M.

AU - Bombardieri, Stefano

AU - Schneider, Matthias

AU - Smith, Vanessa

AU - Vieira, Ana

AU - Cutolo, Maurizio

AU - Mosca, Marta

AU - Tincani, Angela

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Antiphospholipid syndrome (APS) is a rare disease characterised by venous and/or arterial thrombosis, pregnancy complications and the presence of specific autoantibodies called antiphospholipid antibodies. This review aims to identify existing clinical practice guidelines (CPG) as part of the ERN ReCONNET project, aimed at evaluating existing CPGs or recommendations in rare and complex diseases. Seventeen papers providing important data were identified; however, the literature search highlighted the scarceness of reliable clinical data to develop CPGs. With no formal clinical guidelines in place, diagnosis and treatment of APS is largely based on consensus and expert opinion. Patients' unmet need refers to the understanding of the disease and its clinical picture and implications, the need of education for patients, family members and healthcare providers, as well as to the development of monitoring pathways involving multiple healthcare providers.

AB - Antiphospholipid syndrome (APS) is a rare disease characterised by venous and/or arterial thrombosis, pregnancy complications and the presence of specific autoantibodies called antiphospholipid antibodies. This review aims to identify existing clinical practice guidelines (CPG) as part of the ERN ReCONNET project, aimed at evaluating existing CPGs or recommendations in rare and complex diseases. Seventeen papers providing important data were identified; however, the literature search highlighted the scarceness of reliable clinical data to develop CPGs. With no formal clinical guidelines in place, diagnosis and treatment of APS is largely based on consensus and expert opinion. Patients' unmet need refers to the understanding of the disease and its clinical picture and implications, the need of education for patients, family members and healthcare providers, as well as to the development of monitoring pathways involving multiple healthcare providers.

KW - antiphospholipid syndrome

KW - clinical practice guidelines

KW - ERN ReCONNET

KW - European reference networks

KW - unmet needs

UR - https://www.scopus.com/pages/publications/85055704162

U2 - 10.1136/rmdopen-2018-000785

DO - 10.1136/rmdopen-2018-000785

M3 - Review article

C2 - 30402272

SN - 2056-5933

VL - 4

JO - RMD Open

JF - RMD Open

IS - Suppl 1

M1 - e000785

ER -

Antiphospholipid syndrome: State of the art on clinical practice guidelines

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Keywords

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