Antibody targeting of TIRC7 results in significant therapeutic effects on collagen-induced arthritis in mice

N Utku; T Heinemann; M Winter; C G Bulwin; M Schlawinsky; P Fraser; E E S Nieuwenhuis; H-D Volk; R S Blumberg

doi:10.1111/j.1365-2249.2006.03044.x

Antibody targeting of TIRC7 results in significant therapeutic effects on collagen-induced arthritis in mice

N Utku, T Heinemann, M Winter, C G Bulwin, M Schlawinsky, P Fraser, E E S Nieuwenhuis, H-D Volk, R S Blumberg

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

TIRC7 is a cell surface molecule which is expressed in T and B lymphocytes and negatively regulates their function. Anti-TIRC7 specific monoclonal antibody (mAb) inhibited T cell memory response to recall antigens. Up-regulation of TIRC7 on lymphocytes from joint tissue of patients with Rheumatoid Arthritis (RA) and mice with collagen induced arthritis (CIA) suggested TIRC7 as a novel target to promote anti-inflammatory reaction. Anti-TIRC7 mAb administration significantly inhibited the induction and progression of CIA and the anti-collagen IgG1 and IgG2a antibody response. Combination therapy of anti-TIRC7 mAb and soluble TNF-alpha receptor demonstrated an increased inhibitory effect over the single compounds on CIA. The results demonstrate the therapeutic potential of TIRC7 targeting with mAb in diseases associated with exaggerated T and B cell responses.

Original language	English
Pages (from-to)	142-51
Number of pages	10
Journal	Clinical and Experimental Immunology
Volume	144
Issue number	1
DOIs	https://doi.org/10.1111/j.1365-2249.2006.03044.x
Publication status	Published - Apr 2006

Keywords

Animals
Antibodies, Monoclonal
Arthritis, Experimental
Arthritis, Rheumatoid
B-Lymphocytes
Female
Humans
Immunoglobulin G
Immunologic Memory
Immunotherapy
Knee Joint
Male
Mice
Mice, Inbred BALB C
Mice, Inbred DBA
Receptors, Tumor Necrosis Factor
Synovial Fluid
T-Lymphocytes
Tumor Necrosis Factor-alpha
Up-Regulation
Vacuolar Proton-Translocating ATPases

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title = "Antibody targeting of TIRC7 results in significant therapeutic effects on collagen-induced arthritis in mice",

abstract = "TIRC7 is a cell surface molecule which is expressed in T and B lymphocytes and negatively regulates their function. Anti-TIRC7 specific monoclonal antibody (mAb) inhibited T cell memory response to recall antigens. Up-regulation of TIRC7 on lymphocytes from joint tissue of patients with Rheumatoid Arthritis (RA) and mice with collagen induced arthritis (CIA) suggested TIRC7 as a novel target to promote anti-inflammatory reaction. Anti-TIRC7 mAb administration significantly inhibited the induction and progression of CIA and the anti-collagen IgG1 and IgG2a antibody response. Combination therapy of anti-TIRC7 mAb and soluble TNF-alpha receptor demonstrated an increased inhibitory effect over the single compounds on CIA. The results demonstrate the therapeutic potential of TIRC7 targeting with mAb in diseases associated with exaggerated T and B cell responses.",

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author = "N Utku and T Heinemann and M Winter and Bulwin, {C G} and M Schlawinsky and P Fraser and Nieuwenhuis, {E E S} and H-D Volk and Blumberg, {R S}",

year = "2006",

month = apr,

doi = "10.1111/j.1365-2249.2006.03044.x",

language = "English",

volume = "144",

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journal = "Clinical and Experimental Immunology",

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publisher = "Wiley-Blackwell",

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AU - Utku, N

AU - Heinemann, T

AU - Winter, M

AU - Bulwin, C G

AU - Schlawinsky, M

AU - Fraser, P

AU - Nieuwenhuis, E E S

AU - Volk, H-D

AU - Blumberg, R S

PY - 2006/4

Y1 - 2006/4

N2 - TIRC7 is a cell surface molecule which is expressed in T and B lymphocytes and negatively regulates their function. Anti-TIRC7 specific monoclonal antibody (mAb) inhibited T cell memory response to recall antigens. Up-regulation of TIRC7 on lymphocytes from joint tissue of patients with Rheumatoid Arthritis (RA) and mice with collagen induced arthritis (CIA) suggested TIRC7 as a novel target to promote anti-inflammatory reaction. Anti-TIRC7 mAb administration significantly inhibited the induction and progression of CIA and the anti-collagen IgG1 and IgG2a antibody response. Combination therapy of anti-TIRC7 mAb and soluble TNF-alpha receptor demonstrated an increased inhibitory effect over the single compounds on CIA. The results demonstrate the therapeutic potential of TIRC7 targeting with mAb in diseases associated with exaggerated T and B cell responses.

AB - TIRC7 is a cell surface molecule which is expressed in T and B lymphocytes and negatively regulates their function. Anti-TIRC7 specific monoclonal antibody (mAb) inhibited T cell memory response to recall antigens. Up-regulation of TIRC7 on lymphocytes from joint tissue of patients with Rheumatoid Arthritis (RA) and mice with collagen induced arthritis (CIA) suggested TIRC7 as a novel target to promote anti-inflammatory reaction. Anti-TIRC7 mAb administration significantly inhibited the induction and progression of CIA and the anti-collagen IgG1 and IgG2a antibody response. Combination therapy of anti-TIRC7 mAb and soluble TNF-alpha receptor demonstrated an increased inhibitory effect over the single compounds on CIA. The results demonstrate the therapeutic potential of TIRC7 targeting with mAb in diseases associated with exaggerated T and B cell responses.

KW - Animals

KW - Antibodies, Monoclonal

KW - Arthritis, Experimental

KW - Arthritis, Rheumatoid

KW - B-Lymphocytes

KW - Female

KW - Humans

KW - Immunoglobulin G

KW - Immunologic Memory

KW - Immunotherapy

KW - Knee Joint

KW - Male

KW - Mice

KW - Mice, Inbred BALB C

KW - Mice, Inbred DBA

KW - Receptors, Tumor Necrosis Factor

KW - Synovial Fluid

KW - T-Lymphocytes

KW - Tumor Necrosis Factor-alpha

KW - Up-Regulation

KW - Vacuolar Proton-Translocating ATPases

U2 - 10.1111/j.1365-2249.2006.03044.x

DO - 10.1111/j.1365-2249.2006.03044.x

M3 - Article

C2 - 16542376

SN - 0009-9104

VL - 144

SP - 142

EP - 151

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

IS - 1

ER -

Antibody targeting of TIRC7 results in significant therapeutic effects on collagen-induced arthritis in mice

Abstract

Keywords

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