TY - JOUR
T1 - Antibodies to TRIM46 are associated with paraneoplastic neurological syndromes
AU - van Coevorden-Hameete, Marleen H.
AU - van Beuningen, Sam F.B.
AU - Perrenoud, Matthieu
AU - Will, Lena M.
AU - Hulsenboom, Esther
AU - Demonet, Jean Francois
AU - Sabater, Lidia
AU - Kros, Johan M.
AU - Verschuuren, Jan J.G.M.
AU - Titulaer, Maarten J.
AU - de Graaff, Esther
AU - Sillevis Smitt, Peter A.E.
AU - Hoogenraad, Casper C.
N1 - Funding Information:
We thank the patients and their physicians for their trust and collaboration. This study was funded by NUTS-OHRA (1104-034), Hersenstichting (2012(1)-141).
Publisher Copyright:
© 2017 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.
PY - 2017/9
Y1 - 2017/9
N2 - Paraneoplastic neurological syndromes (PNS) are often characterized by the presence of antineuronal antibodies in patient serum or cerebrospinal fluid. The detection of antineuronal antibodies has proven to be a useful tool in PNS diagnosis and the search for an underlying tumor. Here, we describe three patients with autoantibodies to several epitopes of the axon initial segment protein tripartite motif 46 (TRIM46). We show that anti-TRIM46 antibodies are easy to detect in routine immunohistochemistry screening and can be confirmed by western blotting and cell-based assay. Anti-TRIM46 antibodies can occur in patients with diverse neurological syndromes and are associated with small-cell lung carcinoma.
AB - Paraneoplastic neurological syndromes (PNS) are often characterized by the presence of antineuronal antibodies in patient serum or cerebrospinal fluid. The detection of antineuronal antibodies has proven to be a useful tool in PNS diagnosis and the search for an underlying tumor. Here, we describe three patients with autoantibodies to several epitopes of the axon initial segment protein tripartite motif 46 (TRIM46). We show that anti-TRIM46 antibodies are easy to detect in routine immunohistochemistry screening and can be confirmed by western blotting and cell-based assay. Anti-TRIM46 antibodies can occur in patients with diverse neurological syndromes and are associated with small-cell lung carcinoma.
UR - http://www.scopus.com/inward/record.url?scp=85026356058&partnerID=8YFLogxK
U2 - 10.1002/acn3.396
DO - 10.1002/acn3.396
M3 - Article
AN - SCOPUS:85026356058
SN - 2328-9503
VL - 4
SP - 680
EP - 686
JO - Annals of Clinical and Translational Neurology
JF - Annals of Clinical and Translational Neurology
IS - 9
ER -