Antibodies to conserved pneumococcal antigens correlate with, but are not required for, protection against pneumococcal colonization induced by prior exposure in a mouse model

Krzysztof Trzciński; Claudette Thompson; Richard Malley; Marc Lipsitch

doi:10.1128/IAI.73.10.7043-7046.2005

Antibodies to conserved pneumococcal antigens correlate with, but are not required for, protection against pneumococcal colonization induced by prior exposure in a mouse model

Krzysztof Trzciński
, Claudette Thompson
, Richard Malley
, Marc Lipsitch^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

55 Citations (Scopus)

Abstract

In mice following intranasal exposure to Streptococcus pneumoniae, protection against pneumococcal colonization was independent of antibody but dependent on CD4⁺ T cells. Nonetheless, concentrations of antibodies to three conserved pneumococcal antigens correlated with protection against colonization. Concentrations of antibodies to conserved pneumococcal antigens may be correlates of protection without being effectors of protection.

Original language	English
Pages (from-to)	7043-7046
Number of pages	4
Journal	Infection and Immunity
Volume	73
Issue number	10
DOIs	https://doi.org/10.1128/IAI.73.10.7043-7046.2005
Publication status	Published - 1 Oct 2005

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10.1128/IAI.73.10.7043-7046.2005

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title = "Antibodies to conserved pneumococcal antigens correlate with, but are not required for, protection against pneumococcal colonization induced by prior exposure in a mouse model",

abstract = "In mice following intranasal exposure to Streptococcus pneumoniae, protection against pneumococcal colonization was independent of antibody but dependent on CD4+ T cells. Nonetheless, concentrations of antibodies to three conserved pneumococcal antigens correlated with protection against colonization. Concentrations of antibodies to conserved pneumococcal antigens may be correlates of protection without being effectors of protection.",

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Antibodies to conserved pneumococcal antigens correlate with, but are not required for, protection against pneumococcal colonization induced by prior exposure in a mouse model. / Trzciński, Krzysztof; Thompson, Claudette; Malley, Richard et al.
In: Infection and Immunity, Vol. 73, No. 10, 01.10.2005, p. 7043-7046.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Antibodies to conserved pneumococcal antigens correlate with, but are not required for, protection against pneumococcal colonization induced by prior exposure in a mouse model

AU - Trzciński, Krzysztof

AU - Thompson, Claudette

AU - Malley, Richard

AU - Lipsitch, Marc

PY - 2005/10/1

Y1 - 2005/10/1

N2 - In mice following intranasal exposure to Streptococcus pneumoniae, protection against pneumococcal colonization was independent of antibody but dependent on CD4+ T cells. Nonetheless, concentrations of antibodies to three conserved pneumococcal antigens correlated with protection against colonization. Concentrations of antibodies to conserved pneumococcal antigens may be correlates of protection without being effectors of protection.

AB - In mice following intranasal exposure to Streptococcus pneumoniae, protection against pneumococcal colonization was independent of antibody but dependent on CD4+ T cells. Nonetheless, concentrations of antibodies to three conserved pneumococcal antigens correlated with protection against colonization. Concentrations of antibodies to conserved pneumococcal antigens may be correlates of protection without being effectors of protection.

UR - https://www.scopus.com/pages/publications/25444498544

U2 - 10.1128/IAI.73.10.7043-7046.2005

DO - 10.1128/IAI.73.10.7043-7046.2005

M3 - Article

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AN - SCOPUS:25444498544

SN - 0019-9567

VL - 73

SP - 7043

EP - 7046

JO - Infection and Immunity

JF - Infection and Immunity

IS - 10

ER -

Antibodies to conserved pneumococcal antigens correlate with, but are not required for, protection against pneumococcal colonization induced by prior exposure in a mouse model

Abstract

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