TY - JOUR
T1 - Antibodies to conserved pneumococcal antigens correlate with, but are not required for, protection against pneumococcal colonization induced by prior exposure in a mouse model
AU - Trzciński, Krzysztof
AU - Thompson, Claudette
AU - Malley, Richard
AU - Lipsitch, Marc
PY - 2005/10/1
Y1 - 2005/10/1
N2 - In mice following intranasal exposure to Streptococcus pneumoniae, protection against pneumococcal colonization was independent of antibody but dependent on CD4+ T cells. Nonetheless, concentrations of antibodies to three conserved pneumococcal antigens correlated with protection against colonization. Concentrations of antibodies to conserved pneumococcal antigens may be correlates of protection without being effectors of protection.
AB - In mice following intranasal exposure to Streptococcus pneumoniae, protection against pneumococcal colonization was independent of antibody but dependent on CD4+ T cells. Nonetheless, concentrations of antibodies to three conserved pneumococcal antigens correlated with protection against colonization. Concentrations of antibodies to conserved pneumococcal antigens may be correlates of protection without being effectors of protection.
UR - http://www.scopus.com/inward/record.url?scp=25444498544&partnerID=8YFLogxK
U2 - 10.1128/IAI.73.10.7043-7046.2005
DO - 10.1128/IAI.73.10.7043-7046.2005
M3 - Article
C2 - 16177389
AN - SCOPUS:25444498544
SN - 0019-9567
VL - 73
SP - 7043
EP - 7046
JO - Infection and Immunity
JF - Infection and Immunity
IS - 10
ER -