Antibodies against aquaporin-4 in neuromyelitis optica: distinction between recurrent and monophasic patients

Immy A Ketelslegers; Piet W Modderman; Anke Vennegoor; Joep Killestein; Dörte Hamann; Rogier Q Hintzen

doi:10.1177/1352458511412995

Antibodies against aquaporin-4 in neuromyelitis optica: distinction between recurrent and monophasic patients

Immy A Ketelslegers, Piet W Modderman, Anke Vennegoor, Joep Killestein, Dörte Hamann, Rogier Q Hintzen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The detection of antibodies against aquaporin-4 (AQP4) has improved the diagnosis of neuromyelitis optica (NMO). We evaluated a recently established cell-based anti-AQP4 assay in 273 patients with inflammatory CNS demyelination. The assay had a specificity of 99% and a sensitivity of 56% to detect all NMO patients and of 74% to detect the recurrent NMO patients, similar to the initial studies reported. AQP4 antibodies were absent in monophasic NMO patients, while samples in recurrent cases remained positive during follow-up. We conclude that the pathogenesis of monophasic NMO may be different from that of relapsing NMO.

Original language	English
Pages (from-to)	1527-30
Number of pages	4
Journal	Multiple Sclerosis Journal
Volume	17
Issue number	12
DOIs	https://doi.org/10.1177/1352458511412995
Publication status	Published - Dec 2011
Externally published	Yes

Keywords

Aquaporin 4/immunology
Autoantibodies/blood
Diagnosis, Differential
Fluorescent Antibody Technique, Indirect
Follow-Up Studies
Humans
Immunoglobulin G/blood
Multiple Sclerosis/diagnosis
Neuromyelitis Optica/diagnosis
Recurrence
Sensitivity and Specificity

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title = "Antibodies against aquaporin-4 in neuromyelitis optica: distinction between recurrent and monophasic patients",

abstract = "The detection of antibodies against aquaporin-4 (AQP4) has improved the diagnosis of neuromyelitis optica (NMO). We evaluated a recently established cell-based anti-AQP4 assay in 273 patients with inflammatory CNS demyelination. The assay had a specificity of 99% and a sensitivity of 56% to detect all NMO patients and of 74% to detect the recurrent NMO patients, similar to the initial studies reported. AQP4 antibodies were absent in monophasic NMO patients, while samples in recurrent cases remained positive during follow-up. We conclude that the pathogenesis of monophasic NMO may be different from that of relapsing NMO.",

keywords = "Aquaporin 4/immunology, Autoantibodies/blood, Diagnosis, Differential, Fluorescent Antibody Technique, Indirect, Follow-Up Studies, Humans, Immunoglobulin G/blood, Multiple Sclerosis/diagnosis, Neuromyelitis Optica/diagnosis, Recurrence, Sensitivity and Specificity",

author = "Ketelslegers, {Immy A} and Modderman, {Piet W} and Anke Vennegoor and Joep Killestein and D{\"o}rte Hamann and Hintzen, {Rogier Q}",

year = "2011",

month = dec,

doi = "10.1177/1352458511412995",

language = "English",

volume = "17",

pages = "1527--30",

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T1 - Antibodies against aquaporin-4 in neuromyelitis optica

T2 - distinction between recurrent and monophasic patients

AU - Ketelslegers, Immy A

AU - Modderman, Piet W

AU - Vennegoor, Anke

AU - Killestein, Joep

AU - Hamann, Dörte

AU - Hintzen, Rogier Q

PY - 2011/12

Y1 - 2011/12

N2 - The detection of antibodies against aquaporin-4 (AQP4) has improved the diagnosis of neuromyelitis optica (NMO). We evaluated a recently established cell-based anti-AQP4 assay in 273 patients with inflammatory CNS demyelination. The assay had a specificity of 99% and a sensitivity of 56% to detect all NMO patients and of 74% to detect the recurrent NMO patients, similar to the initial studies reported. AQP4 antibodies were absent in monophasic NMO patients, while samples in recurrent cases remained positive during follow-up. We conclude that the pathogenesis of monophasic NMO may be different from that of relapsing NMO.

AB - The detection of antibodies against aquaporin-4 (AQP4) has improved the diagnosis of neuromyelitis optica (NMO). We evaluated a recently established cell-based anti-AQP4 assay in 273 patients with inflammatory CNS demyelination. The assay had a specificity of 99% and a sensitivity of 56% to detect all NMO patients and of 74% to detect the recurrent NMO patients, similar to the initial studies reported. AQP4 antibodies were absent in monophasic NMO patients, while samples in recurrent cases remained positive during follow-up. We conclude that the pathogenesis of monophasic NMO may be different from that of relapsing NMO.

KW - Aquaporin 4/immunology

KW - Autoantibodies/blood

KW - Diagnosis, Differential

KW - Fluorescent Antibody Technique, Indirect

KW - Follow-Up Studies

KW - Humans

KW - Immunoglobulin G/blood

KW - Multiple Sclerosis/diagnosis

KW - Neuromyelitis Optica/diagnosis

KW - Recurrence

KW - Sensitivity and Specificity

U2 - 10.1177/1352458511412995

DO - 10.1177/1352458511412995

M3 - Article

C2 - 21828202

SN - 1352-4585

VL - 17

SP - 1527

EP - 1530

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

IS - 12

ER -

Antibodies against aquaporin-4 in neuromyelitis optica: distinction between recurrent and monophasic patients

Abstract

Keywords

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