Antibacterial activity of antibiotic-soaked polyvinylpyrrolidone-grafted silicon elastomer hydrocephalus shunts

J J Boelens, W F Tan, J Dankert, S A Zaat

Research output: Contribution to journalArticleAcademicpeer-review


If shunts, inserted for the relief of hydrocephalus, are pretreated with antimicrobials, the incidence of shunt-associated infections (SAI) may be reduced. The duration of the antibacterial activity of shunts, made from conventional silicon elastomer (SE) or from SE grafted with the hydrogel polyvinylpyrrolidone (SEpvp), which had been soaked in various antibiotics, was assessed in vitro. For any antibiotic or combination, using an arbitrary breakpoint (aBP), SEpvp remained antibacterially active for longer periods than SE. Bacterial adherence to either shunt was prevented during the period of antibacterial activity. Thus, the aBP is a good indicator of the capacity of antimicrobial-treated shunts to prevent bacterial colonization in vitro. Hydrogel-grafting of shunts may be useful in preventing SAI.

Original languageEnglish
Pages (from-to)221-224
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Issue number2
Publication statusPublished - Feb 2000


  • Anti-Bacterial Agents
  • Bacteria
  • Bacterial Adhesion
  • Hydrocephalus
  • Povidone
  • Silicone Elastomers
  • Staphylococcus


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