TY - JOUR
T1 - Anti-Müllerian hormone does not predict time to pregnancy
T2 - results of a prospective cohort study
AU - Depmann, M.
AU - Broer, S. L.
AU - Eijkemans, M. J.C.
AU - van Rooij, I. A.J.
AU - Scheffer, G. J.
AU - Heimensem, J.
AU - Mol, B. W.
AU - Broekmans, F. J.M.
N1 - Publisher Copyright:
© 2017 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2017/8/3
Y1 - 2017/8/3
N2 - In order to study whether ovarian reserve tests (ORTs) can predict time to ongoing pregnancy, we conducted a prospective cohort study in a cohort of healthy pregnancy planners. A total of 102 pregnancy planners were followed for 1 year, or until ongoing pregnancy occurred, after cessation of contraceptives). A baseline measurement of anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH) and antral follicle count (AFC) was conducted. At the end of follow-up, a semen analysis was performed and chlamydia antibody titres were assessed. A univariate prediction model demonstrated age and the AFC to be significantly capable of predicting time to pregnancy (hazard ratio 0.92, 95% CI 0.87–0.98, p = 0.01; 1.04, 95% CI 1.01–1.07, p = 0.02 respectively). In the multivariate model, however, correcting for female age, we found no predictive effect of AMH, basal FSH or the AFC for time to ongoing pregnancy (hazard ratios 1.43, 95% CI 0.84–2.46, p = 0.36; 0.96, 95% CI 0.86–1.06, p = 0.43; 1.03, 95% CI 1.00–1.07, p = 0.08, respectively). This was confirmed by the low C-statistic. We therefore concluded that baseline AMH, AFC or FSH levels do not predict time to ongoing pregnancy in a cohort of healthy pregnancy planners. These results limit the usability of these ORTs in the assessment of current fertility.
AB - In order to study whether ovarian reserve tests (ORTs) can predict time to ongoing pregnancy, we conducted a prospective cohort study in a cohort of healthy pregnancy planners. A total of 102 pregnancy planners were followed for 1 year, or until ongoing pregnancy occurred, after cessation of contraceptives). A baseline measurement of anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH) and antral follicle count (AFC) was conducted. At the end of follow-up, a semen analysis was performed and chlamydia antibody titres were assessed. A univariate prediction model demonstrated age and the AFC to be significantly capable of predicting time to pregnancy (hazard ratio 0.92, 95% CI 0.87–0.98, p = 0.01; 1.04, 95% CI 1.01–1.07, p = 0.02 respectively). In the multivariate model, however, correcting for female age, we found no predictive effect of AMH, basal FSH or the AFC for time to ongoing pregnancy (hazard ratios 1.43, 95% CI 0.84–2.46, p = 0.36; 0.96, 95% CI 0.86–1.06, p = 0.43; 1.03, 95% CI 1.00–1.07, p = 0.08, respectively). This was confirmed by the low C-statistic. We therefore concluded that baseline AMH, AFC or FSH levels do not predict time to ongoing pregnancy in a cohort of healthy pregnancy planners. These results limit the usability of these ORTs in the assessment of current fertility.
KW - AMH
KW - conception
KW - fecundability
KW - prediction
KW - pregnancy
UR - http://www.scopus.com/inward/record.url?scp=85017205203&partnerID=8YFLogxK
U2 - 10.1080/09513590.2017.1306848
DO - 10.1080/09513590.2017.1306848
M3 - Article
C2 - 28393651
SN - 0951-3590
VL - 33
SP - 644
EP - 648
JO - Gynecological Endocrinology
JF - Gynecological Endocrinology
IS - 8
ER -