TY - JOUR
T1 - Anthropometric characteristics and risk of lymphoid and myeloid leukemia in the European Prospective Investigation into Cancer and Nutrition (EPIC)
AU - Saberi Hosnijeh, Fatemeh
AU - Romieu, Isabelle
AU - Gallo, Valentina
AU - Riboli, Elio
AU - Tjønneland, Anne
AU - Halkjær, Jytte
AU - Fagherazzi, Guy
AU - Clavel-Chapelon, Françoise
AU - Dossus, Laure
AU - Lukanova, Annie
AU - Kaaks, Rudolf
AU - Trichopoulou, Antonia
AU - Lagiou, Pagona
AU - Katsoulis, Michael
AU - Panico, Salvatore
AU - Tagliabue, Giovanna
AU - Bonet, Catalina
AU - Dorronsoro, Miren
AU - Huerta, José María
AU - Ardanaz, Eva
AU - Sánchez, Maria José
AU - Johansen, Dorthe
AU - Borgquist, Signe
AU - Peeters, Petra
AU - Bueno-De-Mesquita, H. Bas
AU - Ros, Martine M.
AU - Travis, Ruth C.
AU - Key, Timothy J.
AU - Vineis, Paolo
AU - Vermeulen, Roel
PY - 2013
Y1 - 2013
N2 - Purpose: Overweight and obesity have been suggested as a risk factor for leukemia. Impaired immune function associated with obesity, increased insulin-like growth factor-I activity and stimulating effects of leptin suggest a possible biological link between anthropometric measures and leukemia. However, evidence from epidemiological studies has been inconsistent. We examined the potential association between prospective measurements of body size and risk of leukemia among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: During follow-up (mean = 11.52 years, standard deviation = 2.63), 671 leukemia (lymphoid leukemia = 50.1 %, myeloid leukemia = 43.2 %) cases were identified. Anthropometric measures including weight, height, body mass index (BMI), waist circumference (WC), hip circumference, and waist-to-hip ratio (WHR) were measured. Cox proportional hazard models were used to explore the association between anthropometric measures and risk of leukemia. Results: No associations were observed between anthropometric measures and total leukemia, and lymphoid leukemia. Risk of myeloid leukemia significantly increased for higher categories of BMI and WC among women. Analyses by subtype of myeloid leukemia showed an increased risk of acute myeloid leukemia (AML) for higher categories of WHR among women. This association seemed to be reversed for chronic myeloid leukemia. No association between anthropometric measures and myeloid leukemia were observed among men except an increased risk of AML with height. Conclusion: The study showed no associations between anthropometric measures and total leukemia, and lymphoid leukemia among men and women. A possible association between BMI as general obesity and WC as abdominal obesity and increased risk of myeloid leukemia among women were observed. © 2012 Springer Science+Business Media Dordrecht.
AB - Purpose: Overweight and obesity have been suggested as a risk factor for leukemia. Impaired immune function associated with obesity, increased insulin-like growth factor-I activity and stimulating effects of leptin suggest a possible biological link between anthropometric measures and leukemia. However, evidence from epidemiological studies has been inconsistent. We examined the potential association between prospective measurements of body size and risk of leukemia among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: During follow-up (mean = 11.52 years, standard deviation = 2.63), 671 leukemia (lymphoid leukemia = 50.1 %, myeloid leukemia = 43.2 %) cases were identified. Anthropometric measures including weight, height, body mass index (BMI), waist circumference (WC), hip circumference, and waist-to-hip ratio (WHR) were measured. Cox proportional hazard models were used to explore the association between anthropometric measures and risk of leukemia. Results: No associations were observed between anthropometric measures and total leukemia, and lymphoid leukemia. Risk of myeloid leukemia significantly increased for higher categories of BMI and WC among women. Analyses by subtype of myeloid leukemia showed an increased risk of acute myeloid leukemia (AML) for higher categories of WHR among women. This association seemed to be reversed for chronic myeloid leukemia. No association between anthropometric measures and myeloid leukemia were observed among men except an increased risk of AML with height. Conclusion: The study showed no associations between anthropometric measures and total leukemia, and lymphoid leukemia among men and women. A possible association between BMI as general obesity and WC as abdominal obesity and increased risk of myeloid leukemia among women were observed. © 2012 Springer Science+Business Media Dordrecht.
KW - Anthropometry
KW - Body mass index
KW - Cohort studies
KW - Leukemia
KW - Lymphoid
KW - Myeloid
UR - https://www.scopus.com/pages/publications/84878872260
U2 - 10.1007/s10552-012-0128-2
DO - 10.1007/s10552-012-0128-2
M3 - Article
C2 - 23288400
SN - 0957-5243
VL - 24
SP - 427
EP - 438
JO - Cancer Causes & Control
JF - Cancer Causes & Control
IS - 3
ER -