Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the perioperative period: withdraw or continue? A multicentre randomised controlled trial

Lynn A Miggelbrink; Wilton A van Klei; Marianne C Verhaar; Folkert W Asselbergs; Wilko Spiering; Wolfgang F F A Buhre; Markus W Hollmann; Felix van Lier; Eric H P A van Dongen; Patrick Schober; Thijs C D Rettig; Hans J B Reitsma; Eva P C van Schaik; Lisette M Vernooij; Judith A R van Waes

doi:10.1016/j.bja.2025.05.056

Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the perioperative period: withdraw or continue? A multicentre randomised controlled trial

Lynn A Miggelbrink^*
, Wilton A van Klei
, Marianne C Verhaar
, Folkert W Asselbergs
, Wilko Spiering
, Wolfgang F F A Buhre
, Markus W Hollmann
, Felix van Lier
, Eric H P A van Dongen
, Patrick Schober
, Thijs C D Rettig
, Hans J B Reitsma
, Eva P C van Schaik
, Lisette M Vernooij
, Judith A R van Waes

^*Corresponding author for this work

Research output: Contribution to journal › Letter › Academic › peer-review

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Original language	English
Pages (from-to)	1075-1077
Number of pages	3
Journal	British Journal of Anaesthesia
Volume	135
Issue number	4
Early online date	22 Jul 2025
DOIs	https://doi.org/10.1016/j.bja.2025.05.056
Publication status	Published - Oct 2025

Keywords

acute kidney injury
angiotensin receptor blockers
angiotensin-converting enzyme inhibitors
noncardiac surgery
perioperative care
randomised controlled trial
renin–angiotensin system inhibitors

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10.1016/j.bja.2025.05.056

1-s2.0-S0007091225004040-mainFinal published version, 310 KBLicence: Taverne

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Miggelbrink, L. A., van Klei, W. A., Verhaar, M. C., Asselbergs, F. W., Spiering, W., Buhre, W. F. F. A., Hollmann, M. W., van Lier, F., van Dongen, E. H. P. A., Schober, P., Rettig, T. C. D., Reitsma, H. J. B., van Schaik, E. P. C., Vernooij, L. M., & van Waes, J. A. R. (2025). Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the perioperative period: withdraw or continue? A multicentre randomised controlled trial. British Journal of Anaesthesia, 135(4), 1075-1077. https://doi.org/10.1016/j.bja.2025.05.056

@article{589ce59fae284d0bbc174f83fc15ccf6,

title = "Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the perioperative period: withdraw or continue? A multicentre randomised controlled trial",

keywords = "acute kidney injury, angiotensin receptor blockers, angiotensin-converting enzyme inhibitors, noncardiac surgery, perioperative care, randomised controlled trial, renin{\textendash}angiotensin system inhibitors",

author = "Miggelbrink, \{Lynn A\} and \{van Klei\}, \{Wilton A\} and Verhaar, \{Marianne C\} and Asselbergs, \{Folkert W\} and Wilko Spiering and Buhre, \{Wolfgang F F A\} and Hollmann, \{Markus W\} and \{van Lier\}, Felix and \{van Dongen\}, \{Eric H P A\} and Patrick Schober and Rettig, \{Thijs C D\} and Reitsma, \{Hans J B\} and \{van Schaik\}, \{Eva P C\} and Vernooij, \{Lisette M\} and \{van Waes\}, \{Judith A R\}",

year = "2025",

month = oct,

doi = "10.1016/j.bja.2025.05.056",

language = "English",

volume = "135",

pages = "1075--1077",

journal = "British Journal of Anaesthesia",

issn = "0007-0912",

publisher = "Elsevier Limited",

number = "4",

}

Miggelbrink, LA, van Klei, WA , Verhaar, MC , Asselbergs, FW , Spiering, W , Buhre, WFFA, Hollmann, MW, van Lier, F, van Dongen, EHPA, Schober, P, Rettig, TCD, Reitsma, HJB, van Schaik, EPC, Vernooij, LM & van Waes, JAR 2025, 'Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the perioperative period: withdraw or continue? A multicentre randomised controlled trial', British Journal of Anaesthesia, vol. 135, no. 4, pp. 1075-1077. https://doi.org/10.1016/j.bja.2025.05.056

Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the perioperative period: withdraw or continue? A multicentre randomised controlled trial. / Miggelbrink, Lynn A; van Klei, Wilton A ; Verhaar, Marianne C et al.
In: British Journal of Anaesthesia, Vol. 135, No. 4, 10.2025, p. 1075-1077.

Research output: Contribution to journal › Letter › Academic › peer-review

TY - JOUR

T1 - Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the perioperative period

T2 - withdraw or continue? A multicentre randomised controlled trial

AU - Miggelbrink, Lynn A

AU - van Klei, Wilton A

AU - Verhaar, Marianne C

AU - Asselbergs, Folkert W

AU - Spiering, Wilko

AU - Buhre, Wolfgang F F A

AU - Hollmann, Markus W

AU - van Lier, Felix

AU - van Dongen, Eric H P A

AU - Schober, Patrick

AU - Rettig, Thijs C D

AU - Reitsma, Hans J B

AU - van Schaik, Eva P C

AU - Vernooij, Lisette M

AU - van Waes, Judith A R

PY - 2025/10

Y1 - 2025/10

KW - acute kidney injury

KW - angiotensin receptor blockers

KW - angiotensin-converting enzyme inhibitors

KW - noncardiac surgery

KW - perioperative care

KW - randomised controlled trial

KW - renin–angiotensin system inhibitors

UR - https://www.scopus.com/pages/publications/105016478464

U2 - 10.1016/j.bja.2025.05.056

DO - 10.1016/j.bja.2025.05.056

M3 - Letter

C2 - 40701887

SN - 0007-0912

VL - 135

SP - 1075

EP - 1077

JO - British Journal of Anaesthesia

JF - British Journal of Anaesthesia

IS - 4

ER -

Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the perioperative period: withdraw or continue? A multicentre randomised controlled trial

Keywords

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