Anaemia is associated with shorter leucocyte telomere length in patients with chronic heart failure

Liza S M Wong; Jardi Huzen; Pim van der Harst; Rudolf A de Boer; Veryan Codd; B Daan Westenbrink; Germaine F J D Benus; Adriaan A Voors; Wiek H van Gilst; Nilesh J Samani; Tiny Jaarsma; Dirk J van Veldhuisen

doi:10.1093/eurjhf/hfq007

Anaemia is associated with shorter leucocyte telomere length in patients with chronic heart failure

Liza S M Wong
, Jardi Huzen
, Pim van der Harst
, Rudolf A de Boer
, Veryan Codd
, B Daan Westenbrink
, Germaine F J D Benus
, Adriaan A Voors
, Wiek H van Gilst
, Nilesh J Samani
, Tiny Jaarsma
, Dirk J van Veldhuisen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

AIMS: Anaemia is highly prevalent and associated with poor prognosis in patients with chronic heart failure (CHF). Reduced erythroid proliferation capacity of haematopoietic progenitor cells is associated with reduced telomere length, a marker of cellular ageing. We hypothesize that short telomere length contributes to the susceptibility to develop anaemia in patients with CHF.

METHODS AND RESULTS: We studied 875 CHF patients, of whom 254 (29%) fulfilled the WHO criteria of anaemia. Telomere length in DNA from peripheral leucocytes was measured with real-time quantitative polymerase chain reaction. Age, gender, and baseline differences adjusted telomere length was correlated with haemoglobin levels (partial r = 0.130; P = 0.011). One standard deviation shorter telomere length was associated with an increased risk of having anaemia [odds ratio (OR), 1.31; 95% confidence interval (CI), 1.12-1.53; P = 0.001]. This observation was not affected by adjustment for potential confounders (OR, 1.38; 95% CI, 1.05-1.81; P = 0.021 after adjustment for age, gender, erythropoietin levels, renal function, left ventricular ejection fraction, age of CHF onset, blood pressure, history of stroke, diabetes, and B-type natriuretic peptide levels).

CONCLUSION: Shorter telomere length increases the odds of having anaemia in CHF patients. This finding supports the hypothesis that cellular ageing in CHF contributes to the susceptibility to develop anaemia.

Original language	English
Pages (from-to)	348-53
Number of pages	6
Journal	European Journal of Heart Failure
Volume	12
Issue number	4
DOIs	https://doi.org/10.1093/eurjhf/hfq007
Publication status	Published - Apr 2010
Externally published	Yes

Keywords

Aged
Aged, 80 and over
Anemia/etiology
Biomarkers
Case-Control Studies
Cellular Senescence
Confidence Intervals
Disease Progression
Female
Heart Failure/complications
Humans
Leukocytes/pathology
Linear Models
Logistic Models
Male
Middle Aged
Natriuretic Peptide, Brain
Odds Ratio
Prognosis
Risk Factors
Stroke Volume
Telomere/ultrastructure
Time Factors
Ventricular Function, Left

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10.1093/eurjhf/hfq007

Cite this

Wong, L. S. M., Huzen, J., van der Harst, P., de Boer, R. A., Codd, V., Westenbrink, B. D., Benus, G. F. J. D., Voors, A. A., van Gilst, W. H., Samani, N. J., Jaarsma, T., & van Veldhuisen, D. J. (2010). Anaemia is associated with shorter leucocyte telomere length in patients with chronic heart failure. European Journal of Heart Failure, 12(4), 348-53. https://doi.org/10.1093/eurjhf/hfq007

@article{fb45451717164d4dbcc35d00d22d827d,

title = "Anaemia is associated with shorter leucocyte telomere length in patients with chronic heart failure",

abstract = "AIMS: Anaemia is highly prevalent and associated with poor prognosis in patients with chronic heart failure (CHF). Reduced erythroid proliferation capacity of haematopoietic progenitor cells is associated with reduced telomere length, a marker of cellular ageing. We hypothesize that short telomere length contributes to the susceptibility to develop anaemia in patients with CHF.METHODS AND RESULTS: We studied 875 CHF patients, of whom 254 (29\%) fulfilled the WHO criteria of anaemia. Telomere length in DNA from peripheral leucocytes was measured with real-time quantitative polymerase chain reaction. Age, gender, and baseline differences adjusted telomere length was correlated with haemoglobin levels (partial r = 0.130; P = 0.011). One standard deviation shorter telomere length was associated with an increased risk of having anaemia [odds ratio (OR), 1.31; 95\% confidence interval (CI), 1.12-1.53; P = 0.001]. This observation was not affected by adjustment for potential confounders (OR, 1.38; 95\% CI, 1.05-1.81; P = 0.021 after adjustment for age, gender, erythropoietin levels, renal function, left ventricular ejection fraction, age of CHF onset, blood pressure, history of stroke, diabetes, and B-type natriuretic peptide levels).CONCLUSION: Shorter telomere length increases the odds of having anaemia in CHF patients. This finding supports the hypothesis that cellular ageing in CHF contributes to the susceptibility to develop anaemia.",

keywords = "Aged, Aged, 80 and over, Anemia/etiology, Biomarkers, Case-Control Studies, Cellular Senescence, Confidence Intervals, Disease Progression, Female, Heart Failure/complications, Humans, Leukocytes/pathology, Linear Models, Logistic Models, Male, Middle Aged, Natriuretic Peptide, Brain, Odds Ratio, Prognosis, Risk Factors, Stroke Volume, Telomere/ultrastructure, Time Factors, Ventricular Function, Left",

author = "Wong, \{Liza S M\} and Jardi Huzen and \{van der Harst\}, Pim and \{de Boer\}, \{Rudolf A\} and Veryan Codd and Westenbrink, \{B Daan\} and Benus, \{Germaine F J D\} and Voors, \{Adriaan A\} and \{van Gilst\}, \{Wiek H\} and Samani, \{Nilesh J\} and Tiny Jaarsma and \{van Veldhuisen\}, \{Dirk J\}",

year = "2010",

month = apr,

doi = "10.1093/eurjhf/hfq007",

language = "English",

volume = "12",

pages = "348--53",

journal = "European Journal of Heart Failure",

issn = "1388-9842",

publisher = "Oxford University Press",

number = "4",

}

Wong, LSM, Huzen, J, van der Harst, P, de Boer, RA, Codd, V, Westenbrink, BD, Benus, GFJD, Voors, AA, van Gilst, WH, Samani, NJ, Jaarsma, T & van Veldhuisen, DJ 2010, 'Anaemia is associated with shorter leucocyte telomere length in patients with chronic heart failure', European Journal of Heart Failure, vol. 12, no. 4, pp. 348-53. https://doi.org/10.1093/eurjhf/hfq007

TY - JOUR

T1 - Anaemia is associated with shorter leucocyte telomere length in patients with chronic heart failure

AU - Wong, Liza S M

AU - Huzen, Jardi

AU - van der Harst, Pim

AU - de Boer, Rudolf A

AU - Codd, Veryan

AU - Westenbrink, B Daan

AU - Benus, Germaine F J D

AU - Voors, Adriaan A

AU - van Gilst, Wiek H

AU - Samani, Nilesh J

AU - Jaarsma, Tiny

AU - van Veldhuisen, Dirk J

PY - 2010/4

Y1 - 2010/4

N2 - AIMS: Anaemia is highly prevalent and associated with poor prognosis in patients with chronic heart failure (CHF). Reduced erythroid proliferation capacity of haematopoietic progenitor cells is associated with reduced telomere length, a marker of cellular ageing. We hypothesize that short telomere length contributes to the susceptibility to develop anaemia in patients with CHF.METHODS AND RESULTS: We studied 875 CHF patients, of whom 254 (29%) fulfilled the WHO criteria of anaemia. Telomere length in DNA from peripheral leucocytes was measured with real-time quantitative polymerase chain reaction. Age, gender, and baseline differences adjusted telomere length was correlated with haemoglobin levels (partial r = 0.130; P = 0.011). One standard deviation shorter telomere length was associated with an increased risk of having anaemia [odds ratio (OR), 1.31; 95% confidence interval (CI), 1.12-1.53; P = 0.001]. This observation was not affected by adjustment for potential confounders (OR, 1.38; 95% CI, 1.05-1.81; P = 0.021 after adjustment for age, gender, erythropoietin levels, renal function, left ventricular ejection fraction, age of CHF onset, blood pressure, history of stroke, diabetes, and B-type natriuretic peptide levels).CONCLUSION: Shorter telomere length increases the odds of having anaemia in CHF patients. This finding supports the hypothesis that cellular ageing in CHF contributes to the susceptibility to develop anaemia.

AB - AIMS: Anaemia is highly prevalent and associated with poor prognosis in patients with chronic heart failure (CHF). Reduced erythroid proliferation capacity of haematopoietic progenitor cells is associated with reduced telomere length, a marker of cellular ageing. We hypothesize that short telomere length contributes to the susceptibility to develop anaemia in patients with CHF.METHODS AND RESULTS: We studied 875 CHF patients, of whom 254 (29%) fulfilled the WHO criteria of anaemia. Telomere length in DNA from peripheral leucocytes was measured with real-time quantitative polymerase chain reaction. Age, gender, and baseline differences adjusted telomere length was correlated with haemoglobin levels (partial r = 0.130; P = 0.011). One standard deviation shorter telomere length was associated with an increased risk of having anaemia [odds ratio (OR), 1.31; 95% confidence interval (CI), 1.12-1.53; P = 0.001]. This observation was not affected by adjustment for potential confounders (OR, 1.38; 95% CI, 1.05-1.81; P = 0.021 after adjustment for age, gender, erythropoietin levels, renal function, left ventricular ejection fraction, age of CHF onset, blood pressure, history of stroke, diabetes, and B-type natriuretic peptide levels).CONCLUSION: Shorter telomere length increases the odds of having anaemia in CHF patients. This finding supports the hypothesis that cellular ageing in CHF contributes to the susceptibility to develop anaemia.

KW - Aged

KW - Aged, 80 and over

KW - Anemia/etiology

KW - Biomarkers

KW - Case-Control Studies

KW - Cellular Senescence

KW - Confidence Intervals

KW - Disease Progression

KW - Female

KW - Heart Failure/complications

KW - Humans

KW - Leukocytes/pathology

KW - Linear Models

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Natriuretic Peptide, Brain

KW - Odds Ratio

KW - Prognosis

KW - Risk Factors

KW - Stroke Volume

KW - Telomere/ultrastructure

KW - Time Factors

KW - Ventricular Function, Left

U2 - 10.1093/eurjhf/hfq007

DO - 10.1093/eurjhf/hfq007

M3 - Article

C2 - 20335352

SN - 1388-9842

VL - 12

SP - 348

EP - 353

JO - European Journal of Heart Failure

JF - European Journal of Heart Failure

IS - 4

ER -

Anaemia is associated with shorter leucocyte telomere length in patients with chronic heart failure

Abstract

Keywords

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