TY - JOUR
T1 - An RF coil design to enable quintuple nuclear whole-brain MRI
AU - Dai, Jiying
AU - Gosselink, Mark
AU - van der Velden, Tijl Antonius
AU - Meliadò, Ettore Flavio
AU - Raaijmakers, Alexander Jan Eberhard
AU - Klomp, Dennis Wilhelmus Johannes
N1 - Funding Information:
information Nederlandse Organisatie voor Wetenschappelijk Onderzoek and KWF Kankerbestrijding, Grant/Award Number: 17907
Publisher Copyright:
© 2023 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.
PY - 2023/5
Y1 - 2023/5
N2 - Purpose: To bring metabolic imaging based on multi-NMR toward practical use from the RF hardware perspective. Methods: A highly integrated RF coil is designed for whole-brain MRI and MRS targeted to five nuclear species: 1H, 19F, 31P, 23Na, and 13C. Dipole antennas and closely loaded local receiver loops are combined in this setup. Results: High-quality in vivo scan results of 1H, 31P, 23Na, and 13C on healthy volunteers have been achieved. For 1H, the transmit efficiency is 77% of a single-tuned commercial head coil (NOVA 8-transmit [Tx]/32-receive [Rx]; NOVA Medical, Wilmington, MA, USA). For 31P, 110% SNR of a dual-tuned close-fit head-birdcage was achieved at the center of the subject, based on MR experiments on a phantom. For 31P, 23Na, and 13C, bench measurements indicate SNR loss of 15%, 27%, and 30% compared with single-tuned conditions. 19F performance has been proven to be similar to that of 1H through bench tests and electromagnetic simulations. Conclusion: With this device, 1H-based anatomic images that are expected to meet clinical requirements, as well as high-quality multi-NMR images and spectra, can be acquired within one scan session without hardware replacement or patient repositioning, enabling morphologic and metabolic MRI within acceptable scan time.
AB - Purpose: To bring metabolic imaging based on multi-NMR toward practical use from the RF hardware perspective. Methods: A highly integrated RF coil is designed for whole-brain MRI and MRS targeted to five nuclear species: 1H, 19F, 31P, 23Na, and 13C. Dipole antennas and closely loaded local receiver loops are combined in this setup. Results: High-quality in vivo scan results of 1H, 31P, 23Na, and 13C on healthy volunteers have been achieved. For 1H, the transmit efficiency is 77% of a single-tuned commercial head coil (NOVA 8-transmit [Tx]/32-receive [Rx]; NOVA Medical, Wilmington, MA, USA). For 31P, 110% SNR of a dual-tuned close-fit head-birdcage was achieved at the center of the subject, based on MR experiments on a phantom. For 31P, 23Na, and 13C, bench measurements indicate SNR loss of 15%, 27%, and 30% compared with single-tuned conditions. 19F performance has been proven to be similar to that of 1H through bench tests and electromagnetic simulations. Conclusion: With this device, 1H-based anatomic images that are expected to meet clinical requirements, as well as high-quality multi-NMR images and spectra, can be acquired within one scan session without hardware replacement or patient repositioning, enabling morphologic and metabolic MRI within acceptable scan time.
KW - metabolic imaging
KW - multinuclear
KW - RF coil
UR - http://www.scopus.com/inward/record.url?scp=85147508681&partnerID=8YFLogxK
U2 - 10.1002/mrm.29577
DO - 10.1002/mrm.29577
M3 - Article
C2 - 36740899
AN - SCOPUS:85147508681
SN - 0740-3194
VL - 89
SP - 2131
EP - 2141
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
IS - 5
ER -