An observational study on disturbed peripheral circadian rhythms in hemodialysis patients

Marije Russcher; Ines Chaves; Karolina Lech; Birgit C. P. Koch; J. Elsbeth Nagtegaal; Kira F. Dorsman; Anke't Jong; Manfred Kayser; H. (Martijn) J. R. van Faassen; Ido P. Kema; Gijsbertus T. J. van der Horst; Carlo A. J. M. Gaillard

doi:10.3109/07420528.2015.1048868

An observational study on disturbed peripheral circadian rhythms in hemodialysis patients

Marije Russcher, Ines Chaves, Karolina Lech, Birgit C. P. Koch, J. Elsbeth Nagtegaal, Kira F. Dorsman, Anke't Jong, Manfred Kayser, H. (Martijn) J. R. van Faassen, Ido P. Kema, Gijsbertus T. J. van der Horst, Carlo A. J. M. Gaillard

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The quality of life of hemodialysis (HD) patients is hampered by reduced nocturnal sleep quality and excessive daytime sleepiness. In addition to the sleep/wake cycle, levels of circadian biomarkers (e.g. melatonin) are disturbed in end-stage renal disease (ESRD). This suggests impaired circadian clock performance in HD patients, but the underlying mechanism is unknown. In this observational study, diurnal rhythms of sleep, serum melatonin and cortisol concentrations and clock gene mRNA expression are compared between HD patients (n = 9) and healthy control subjects (n = 9). In addition, the presence of circulating factors that might affect circadian rhythmicity is tested in vitro with cell culture experiments. Reduced sleep quality (median sleep onset latency [interquartile range] of 23.9 [17.3] min for patients versus 5.0 [10] minutes for controls, p

Original language	English
Pages (from-to)	848-857
Number of pages	10
Journal	Chronobiology International
Volume	32
Issue number	6
DOIs	https://doi.org/10.3109/07420528.2015.1048868
Publication status	Published - Jul 2015
Externally published	Yes

Keywords

Circadian clock
clock genes
clock synchronization
cortisol
end-stage renal disease
hemodialysis
melatonin
sleep
GENE-EXPRESSION
MELATONIN
CLOCK
SLEEP
VARIABILITY
KIDNEY
PERIOD
MICE

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Russcher, M., Chaves, I., Lech, K., Koch, B. C. P., Nagtegaal, J. E., Dorsman, K. F., Jong, A., Kayser, M., van Faassen, H. J. R., Kema, I. P., van der Horst, G. T. J., & Gaillard, C. A. J. M. (2015). An observational study on disturbed peripheral circadian rhythms in hemodialysis patients. Chronobiology International, 32(6), 848-857. https://doi.org/10.3109/07420528.2015.1048868

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title = "An observational study on disturbed peripheral circadian rhythms in hemodialysis patients",

abstract = "The quality of life of hemodialysis (HD) patients is hampered by reduced nocturnal sleep quality and excessive daytime sleepiness. In addition to the sleep/wake cycle, levels of circadian biomarkers (e.g. melatonin) are disturbed in end-stage renal disease (ESRD). This suggests impaired circadian clock performance in HD patients, but the underlying mechanism is unknown. In this observational study, diurnal rhythms of sleep, serum melatonin and cortisol concentrations and clock gene mRNA expression are compared between HD patients (n = 9) and healthy control subjects (n = 9). In addition, the presence of circulating factors that might affect circadian rhythmicity is tested in vitro with cell culture experiments. Reduced sleep quality (median sleep onset latency [interquartile range] of 23.9 [17.3] min for patients versus 5.0 [10] minutes for controls, p ",

keywords = "Circadian clock, clock genes, clock synchronization, cortisol, end-stage renal disease, hemodialysis, melatonin, sleep, GENE-EXPRESSION, MELATONIN, CLOCK, SLEEP, VARIABILITY, KIDNEY, PERIOD, MICE",

author = "Marije Russcher and Ines Chaves and Karolina Lech and Koch, {Birgit C. P.} and Nagtegaal, {J. Elsbeth} and Dorsman, {Kira F.} and Anke't Jong and Manfred Kayser and {van Faassen}, {H. (Martijn) J. R.} and Kema, {Ido P.} and {van der Horst}, {Gijsbertus T. J.} and Gaillard, {Carlo A. J. M.}",

year = "2015",

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doi = "10.3109/07420528.2015.1048868",

language = "English",

volume = "32",

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AU - Russcher, Marije

AU - Chaves, Ines

AU - Lech, Karolina

AU - Koch, Birgit C. P.

AU - Nagtegaal, J. Elsbeth

AU - Dorsman, Kira F.

AU - Jong, Anke't

AU - Kayser, Manfred

AU - van Faassen, H. (Martijn) J. R.

AU - Kema, Ido P.

AU - van der Horst, Gijsbertus T. J.

AU - Gaillard, Carlo A. J. M.

PY - 2015/7

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N2 - The quality of life of hemodialysis (HD) patients is hampered by reduced nocturnal sleep quality and excessive daytime sleepiness. In addition to the sleep/wake cycle, levels of circadian biomarkers (e.g. melatonin) are disturbed in end-stage renal disease (ESRD). This suggests impaired circadian clock performance in HD patients, but the underlying mechanism is unknown. In this observational study, diurnal rhythms of sleep, serum melatonin and cortisol concentrations and clock gene mRNA expression are compared between HD patients (n = 9) and healthy control subjects (n = 9). In addition, the presence of circulating factors that might affect circadian rhythmicity is tested in vitro with cell culture experiments. Reduced sleep quality (median sleep onset latency [interquartile range] of 23.9 [17.3] min for patients versus 5.0 [10] minutes for controls, p

AB - The quality of life of hemodialysis (HD) patients is hampered by reduced nocturnal sleep quality and excessive daytime sleepiness. In addition to the sleep/wake cycle, levels of circadian biomarkers (e.g. melatonin) are disturbed in end-stage renal disease (ESRD). This suggests impaired circadian clock performance in HD patients, but the underlying mechanism is unknown. In this observational study, diurnal rhythms of sleep, serum melatonin and cortisol concentrations and clock gene mRNA expression are compared between HD patients (n = 9) and healthy control subjects (n = 9). In addition, the presence of circulating factors that might affect circadian rhythmicity is tested in vitro with cell culture experiments. Reduced sleep quality (median sleep onset latency [interquartile range] of 23.9 [17.3] min for patients versus 5.0 [10] minutes for controls, p

KW - Circadian clock

KW - clock genes

KW - clock synchronization

KW - cortisol

KW - end-stage renal disease

KW - hemodialysis

KW - melatonin

KW - sleep

KW - GENE-EXPRESSION

KW - MELATONIN

KW - CLOCK

KW - SLEEP

KW - VARIABILITY

KW - KIDNEY

KW - PERIOD

KW - MICE

U2 - 10.3109/07420528.2015.1048868

DO - 10.3109/07420528.2015.1048868

M3 - Article

SN - 1525-6073

VL - 32

SP - 848

EP - 857

JO - Chronobiology International

JF - Chronobiology International

IS - 6

ER -

An observational study on disturbed peripheral circadian rhythms in hemodialysis patients

Abstract

Keywords

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