TY - JOUR
T1 - An observational cohort of patients with colorectal peritoneal metastases or pseudomyxoma peritonei treated with CRS-HIPEC
T2 - Development and first results of the Dutch CRS-HIPEC quality registry
AU - van Erning, Felice N.
AU - van den Heuvel, Teun B.M.
AU - Sijtsma, Femke P.C.
AU - Boerma, Djamila
AU - Brandt-Kerkhof, Alexandra R.M.
AU - Bremers, André J.
AU - van Duyn, Eino B.
AU - van Grevenstein, Helma M.U.
AU - Hemmer, Patrick H.J.
AU - Kok, Niels F.M.
AU - Madsen, Eva
AU - de Reuver, Philip R.
AU - Wiezer, René J.
AU - Witkamp, Arjan J.
AU - Nienhuijs, Simon W.
AU - Poelmann, Floris B.
AU - Tuynman, Jurriaan B.
AU - Been, Lucas B.
AU - Rovers, Koen P.
AU - de Hingh, Ignace H.J.T.
N1 - Publisher Copyright:
© 2024 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology
PY - 2024/12
Y1 - 2024/12
N2 - Introduction: To improve care for patients with colorectal peritoneal metastases (CRC-PM) or pseudomyxoma peritonei (PMP), the Dutch CRS-HIPEC quality registry was initiated in 2019. The aims are to describe the development and content of this registry and to give insight into the data collected during the first years. Materials and methods: The registry is an observational cohort in the Netherlands. All patients with CRC-PM or PMP who intend to undergo cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) from 6 hospitals are included. Clinical data and outcomes (including hospital variation) were analyzed. Results: In 2019–2022, 889 patients were included in the CRS-HIPEC quality registry: 749 (84 %) with CRC-PM and 140 (16 %) with PMP. Peritoneal metastases were diagnosed synchronously in 51 % of CRC-PM patients and in 94 % of PMP patients. In patients undergoing complete CRS, the median peritoneal cancer index was 8 (IQR 4–13) for CRC-PM and 15 (IQR 6–26) for PMP. Complete cytoreduction was achieved in 639 CRC-PM patients (97 %) and 108 PMP patients (82 %). HIPEC was mainly performed with mitomycin C (CRC-PM: 94 %, PMP: 92 %). Major postoperative complications (Clavien-Dindo grade ≥3) occurred in 148 CRC-PM patients (22 %) and 30 PMP patients (23 %) with 90-day mortality rates of 2 %. In CRC-PM, differences between hospitals were observed regarding proportions of diagnostic laparoscopies/laparotomies, (neo)adjuvant treatment, ostomy formations and re-admissions. Conclusion: The CRS-HIPEC quality registry provides insight into the outcomes of CRS-HIPEC and enables clinical auditing and observational cohort studies aiming to improve treatment outcomes for patients with CRC-PM and PMP.
AB - Introduction: To improve care for patients with colorectal peritoneal metastases (CRC-PM) or pseudomyxoma peritonei (PMP), the Dutch CRS-HIPEC quality registry was initiated in 2019. The aims are to describe the development and content of this registry and to give insight into the data collected during the first years. Materials and methods: The registry is an observational cohort in the Netherlands. All patients with CRC-PM or PMP who intend to undergo cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) from 6 hospitals are included. Clinical data and outcomes (including hospital variation) were analyzed. Results: In 2019–2022, 889 patients were included in the CRS-HIPEC quality registry: 749 (84 %) with CRC-PM and 140 (16 %) with PMP. Peritoneal metastases were diagnosed synchronously in 51 % of CRC-PM patients and in 94 % of PMP patients. In patients undergoing complete CRS, the median peritoneal cancer index was 8 (IQR 4–13) for CRC-PM and 15 (IQR 6–26) for PMP. Complete cytoreduction was achieved in 639 CRC-PM patients (97 %) and 108 PMP patients (82 %). HIPEC was mainly performed with mitomycin C (CRC-PM: 94 %, PMP: 92 %). Major postoperative complications (Clavien-Dindo grade ≥3) occurred in 148 CRC-PM patients (22 %) and 30 PMP patients (23 %) with 90-day mortality rates of 2 %. In CRC-PM, differences between hospitals were observed regarding proportions of diagnostic laparoscopies/laparotomies, (neo)adjuvant treatment, ostomy formations and re-admissions. Conclusion: The CRS-HIPEC quality registry provides insight into the outcomes of CRS-HIPEC and enables clinical auditing and observational cohort studies aiming to improve treatment outcomes for patients with CRC-PM and PMP.
KW - Colorectal cancer
KW - CRS-HIPEC
KW - Observational cohort
KW - Peritoneal metastases
KW - Pseudomyxoma peritonei
KW - Registry
UR - http://www.scopus.com/inward/record.url?scp=85202936556&partnerID=8YFLogxK
U2 - 10.1016/j.ejso.2024.108568
DO - 10.1016/j.ejso.2024.108568
M3 - Article
AN - SCOPUS:85202936556
SN - 0748-7983
VL - 50
JO - European Journal of Surgical Oncology
JF - European Journal of Surgical Oncology
IS - 12
M1 - 108568
ER -