An international Ki67 reproducibility study in adrenal cortical Carcinoma

Thomas G. Papathomas; Eugenio Pucci; Thomas J. Giordano; Hao Lu; Eleonora Duregon; Marco Volante; Mauro Papotti; Ricardo V. Lloyd; Arthur S. Tischler; Francien H. Van Nederveen; Vania Nose; Lori Erickson; Ozgur Mete; Sylvia L. Asa; John Turchini; Anthony J. Gill; Xavier Matias-Guiu; Kassiani Skordilis; Timothy J. Stephenson; Frederique Tissier; Richard A. Feelders; Marcel Smid; Alex Nigg; Esther Korpershoek; Peter J. Van Der Spek; Winand N M Dinjens; Andrew P. Stubbs; Ronald R. De Krijger

doi:10.1097/PAS.0000000000000574

An international Ki67 reproducibility study in adrenal cortical Carcinoma

Thomas G. Papathomas^*, Eugenio Pucci, Thomas J. Giordano, Hao Lu, Eleonora Duregon, Marco Volante, Mauro Papotti, Ricardo V. Lloyd, Arthur S. Tischler, Francien H. Van Nederveen, Vania Nose, Lori Erickson, Ozgur Mete, Sylvia L. Asa, John Turchini, Anthony J. Gill, Xavier Matias-Guiu, Kassiani Skordilis, Timothy J. Stephenson, Frederique TissierRichard A. Feelders, Marcel Smid, Alex Nigg, Esther Korpershoek, Peter J. Van Der Spek, Winand N M Dinjens, Andrew P. Stubbs, Ronald R. De Krijger

^*Corresponding author for this work

Department of Pathology

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

Abstract

Despite the established role of Ki67 labeling index in prognostic stratification of adrenocortical carcinomas and its recent integration into treatment flow charts, the reproducibility of the assessment method has not been determined. The aim of this study was to investigate interobserver variability among endocrine pathologists using a web-based virtual microscopy approach. Ki67-stained slides of 76 adrenocortical carcinomas were analyzed independently by 14 observers, each according to their method of preference including eyeballing, formal manual counting, and digital image analysis. The interobserver variation was statistically significant (P

Original language	English
Pages (from-to)	569-576
Number of pages	8
Journal	American Journal of Surgical Pathology
Volume	40
Issue number	4
DOIs	https://doi.org/10.1097/PAS.0000000000000574
Publication status	Published - 2016

Keywords

Adrenal cortical carcinoma
Digital pathology
Interobserver variation
Ki67 labeling index
Proliferation

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Papathomas, T. G., Pucci, E., Giordano, T. J., Lu, H., Duregon, E., Volante, M., Papotti, M., Lloyd, R. V., Tischler, A. S., Van Nederveen, F. H., Nose, V., Erickson, L., Mete, O., Asa, S. L., Turchini, J., Gill, A. J., Matias-Guiu, X., Skordilis, K., Stephenson, T. J., ... De Krijger, R. R. (2016). An international Ki67 reproducibility study in adrenal cortical Carcinoma. American Journal of Surgical Pathology, 40(4), 569-576. https://doi.org/10.1097/PAS.0000000000000574

@article{dc6e75ac2c8140b5b5df8013cd21bf35,

title = "An international Ki67 reproducibility study in adrenal cortical Carcinoma",

abstract = "Despite the established role of Ki67 labeling index in prognostic stratification of adrenocortical carcinomas and its recent integration into treatment flow charts, the reproducibility of the assessment method has not been determined. The aim of this study was to investigate interobserver variability among endocrine pathologists using a web-based virtual microscopy approach. Ki67-stained slides of 76 adrenocortical carcinomas were analyzed independently by 14 observers, each according to their method of preference including eyeballing, formal manual counting, and digital image analysis. The interobserver variation was statistically significant (P",

keywords = "Adrenal cortical carcinoma, Digital pathology, Interobserver variation, Ki67 labeling index, Proliferation",

author = "Papathomas, {Thomas G.} and Eugenio Pucci and Giordano, {Thomas J.} and Hao Lu and Eleonora Duregon and Marco Volante and Mauro Papotti and Lloyd, {Ricardo V.} and Tischler, {Arthur S.} and {Van Nederveen}, {Francien H.} and Vania Nose and Lori Erickson and Ozgur Mete and Asa, {Sylvia L.} and John Turchini and Gill, {Anthony J.} and Xavier Matias-Guiu and Kassiani Skordilis and Stephenson, {Timothy J.} and Frederique Tissier and Feelders, {Richard A.} and Marcel Smid and Alex Nigg and Esther Korpershoek and {Van Der Spek}, {Peter J.} and Dinjens, {Winand N M} and Stubbs, {Andrew P.} and {De Krijger}, {Ronald R.}",

year = "2016",

doi = "10.1097/PAS.0000000000000574",

language = "English",

volume = "40",

pages = "569--576",

journal = "American Journal of Surgical Pathology",

issn = "0147-5185",

publisher = "Lippincott Williams & Wilkins",

number = "4",

}

Papathomas, TG, Pucci, E, Giordano, TJ, Lu, H, Duregon, E, Volante, M, Papotti, M, Lloyd, RV, Tischler, AS, Van Nederveen, FH, Nose, V, Erickson, L, Mete, O, Asa, SL, Turchini, J, Gill, AJ, Matias-Guiu, X, Skordilis, K, Stephenson, TJ, Tissier, F, Feelders, RA, Smid, M, Nigg, A, Korpershoek, E, Van Der Spek, PJ, Dinjens, WNM, Stubbs, AP & De Krijger, RR 2016, 'An international Ki67 reproducibility study in adrenal cortical Carcinoma', American Journal of Surgical Pathology, vol. 40, no. 4, pp. 569-576. https://doi.org/10.1097/PAS.0000000000000574

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AU - Papathomas, Thomas G.

AU - Pucci, Eugenio

AU - Giordano, Thomas J.

AU - Lu, Hao

AU - Duregon, Eleonora

AU - Volante, Marco

AU - Papotti, Mauro

AU - Lloyd, Ricardo V.

AU - Tischler, Arthur S.

AU - Van Nederveen, Francien H.

AU - Nose, Vania

AU - Erickson, Lori

AU - Mete, Ozgur

AU - Asa, Sylvia L.

AU - Turchini, John

AU - Gill, Anthony J.

AU - Matias-Guiu, Xavier

AU - Skordilis, Kassiani

AU - Stephenson, Timothy J.

AU - Tissier, Frederique

AU - Feelders, Richard A.

AU - Smid, Marcel

AU - Nigg, Alex

AU - Korpershoek, Esther

AU - Van Der Spek, Peter J.

AU - Dinjens, Winand N M

AU - Stubbs, Andrew P.

AU - De Krijger, Ronald R.

PY - 2016

Y1 - 2016

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KW - Adrenal cortical carcinoma

KW - Digital pathology

KW - Interobserver variation

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KW - Proliferation

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JO - American Journal of Surgical Pathology

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ER -

An international Ki67 reproducibility study in adrenal cortical Carcinoma

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Keywords

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