An evidence-based analysis of the management of N0 neck in patients with cancer of the parotid gland

Jose Guilherme Vartanian; Joao Gonçalves Filho; Luiz Paulo Kowalski; Jatin P. Shah; Carlos Suárez; Alessandra Rinaldo; Remco De Bree; Juan P. Rodrigo; Marc Hamoir; Robert P. Takes; Antti A. Mäkitie; Peter Zbären; Simon Andreasen; Vincent Vander Poorten; Alvaro Sanabria; Henrik Hellquist; K. Thomas Robbins; Carsten C. Bödeker; Carl Silver; Alfio Ferlito

doi:10.1080/14737140.2019.1674143

An evidence-based analysis of the management of N0 neck in patients with cancer of the parotid gland

Jose Guilherme Vartanian^*
, Joao Gonçalves Filho
, Luiz Paulo Kowalski
, Jatin P. Shah
, Carlos Suárez
, Alessandra Rinaldo
, Remco De Bree
, Juan P. Rodrigo
, Marc Hamoir
, Robert P. Takes
, Antti A. Mäkitie
, Peter Zbären
, Simon Andreasen
, Vincent Vander Poorten
, Alvaro Sanabria
, Henrik Hellquist
, K. Thomas Robbins
, Carsten C. Bödeker
, Carl Silver
, Alfio Ferlito

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

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Abstract

Introduction: Management of clinically negative neck (cN0) in patients with parotid gland cancer is controversial. Treatment options can include observation, elective neck dissection or elective radiotherapy. Areas covered: We addressed the treatment options for cN0 patients with parotid gland cancer. A literature review was undertaken to determine the optimal management of this group of patients. Expert opinion: Patients with parotid carcinoma and clinically negative neck have various options for their management. The analysis of tumor stage, histology and grade is essential to better define patients at risk for occult lymph node metastasis. These patients can be managed by surgery, radiotherapy or their combination, depending on the presence of risk factors, the moment at which such risk factors are detected, patient-related clinical conditions, medical provider expertise and institutional facilities.

Original language	English
Pages (from-to)	899-908
Number of pages	10
Journal	Expert Review of Anticancer Therapy
Volume	19
Issue number	10
DOIs	https://doi.org/10.1080/14737140.2019.1674143
Publication status	Published - 3 Oct 2019

Keywords

elective neck treatment
neck dissection
parotid gland
radiotherapy
Salivary gland

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10.1080/14737140.2019.1674143

vartanianFinal published version, 1.21 MBLicence: Taverne

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Vartanian, J. G., Gonçalves Filho, J., Kowalski, L. P., Shah, J. P., Suárez, C., Rinaldo, A., De Bree, R., Rodrigo, J. P., Hamoir, M., Takes, R. P., Mäkitie, A. A., Zbären, P., Andreasen, S., Poorten, V. V., Sanabria, A., Hellquist, H., Robbins, K. T., Bödeker, C. C., Silver, C., & Ferlito, A. (2019). An evidence-based analysis of the management of N0 neck in patients with cancer of the parotid gland. Expert Review of Anticancer Therapy, 19(10), 899-908. https://doi.org/10.1080/14737140.2019.1674143

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title = "An evidence-based analysis of the management of N0 neck in patients with cancer of the parotid gland",

abstract = "Introduction: Management of clinically negative neck (cN0) in patients with parotid gland cancer is controversial. Treatment options can include observation, elective neck dissection or elective radiotherapy. Areas covered: We addressed the treatment options for cN0 patients with parotid gland cancer. A literature review was undertaken to determine the optimal management of this group of patients. Expert opinion: Patients with parotid carcinoma and clinically negative neck have various options for their management. The analysis of tumor stage, histology and grade is essential to better define patients at risk for occult lymph node metastasis. These patients can be managed by surgery, radiotherapy or their combination, depending on the presence of risk factors, the moment at which such risk factors are detected, patient-related clinical conditions, medical provider expertise and institutional facilities.",

keywords = "elective neck treatment, neck dissection, parotid gland, radiotherapy, Salivary gland",

author = "Vartanian, \{Jose Guilherme\} and \{Gon{\c c}alves Filho\}, Joao and Kowalski, \{Luiz Paulo\} and Shah, \{Jatin P.\} and Carlos Su{\'a}rez and Alessandra Rinaldo and \{De Bree\}, Remco and Rodrigo, \{Juan P.\} and Marc Hamoir and Takes, \{Robert P.\} and M{\"a}kitie, \{Antti A.\} and Peter Zb{\"a}ren and Simon Andreasen and Poorten, \{Vincent Vander\} and Alvaro Sanabria and Henrik Hellquist and Robbins, \{K. Thomas\} and B{\"o}deker, \{Carsten C.\} and Carl Silver and Alfio Ferlito",

year = "2019",

month = oct,

day = "3",

doi = "10.1080/14737140.2019.1674143",

language = "English",

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pages = "899--908",

journal = "Expert Review of Anticancer Therapy",

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Vartanian, JG, Gonçalves Filho, J, Kowalski, LP, Shah, JP, Suárez, C, Rinaldo, A, De Bree, R, Rodrigo, JP, Hamoir, M, Takes, RP, Mäkitie, AA, Zbären, P, Andreasen, S, Poorten, VV, Sanabria, A, Hellquist, H, Robbins, KT, Bödeker, CC, Silver, C & Ferlito, A 2019, 'An evidence-based analysis of the management of N0 neck in patients with cancer of the parotid gland', Expert Review of Anticancer Therapy, vol. 19, no. 10, pp. 899-908. https://doi.org/10.1080/14737140.2019.1674143

TY - JOUR

T1 - An evidence-based analysis of the management of N0 neck in patients with cancer of the parotid gland

AU - Vartanian, Jose Guilherme

AU - Gonçalves Filho, Joao

AU - Kowalski, Luiz Paulo

AU - Shah, Jatin P.

AU - Suárez, Carlos

AU - Rinaldo, Alessandra

AU - De Bree, Remco

AU - Rodrigo, Juan P.

AU - Hamoir, Marc

AU - Takes, Robert P.

AU - Mäkitie, Antti A.

AU - Zbären, Peter

AU - Andreasen, Simon

AU - Poorten, Vincent Vander

AU - Sanabria, Alvaro

AU - Hellquist, Henrik

AU - Robbins, K. Thomas

AU - Bödeker, Carsten C.

AU - Silver, Carl

AU - Ferlito, Alfio

PY - 2019/10/3

Y1 - 2019/10/3

N2 - Introduction: Management of clinically negative neck (cN0) in patients with parotid gland cancer is controversial. Treatment options can include observation, elective neck dissection or elective radiotherapy. Areas covered: We addressed the treatment options for cN0 patients with parotid gland cancer. A literature review was undertaken to determine the optimal management of this group of patients. Expert opinion: Patients with parotid carcinoma and clinically negative neck have various options for their management. The analysis of tumor stage, histology and grade is essential to better define patients at risk for occult lymph node metastasis. These patients can be managed by surgery, radiotherapy or their combination, depending on the presence of risk factors, the moment at which such risk factors are detected, patient-related clinical conditions, medical provider expertise and institutional facilities.

AB - Introduction: Management of clinically negative neck (cN0) in patients with parotid gland cancer is controversial. Treatment options can include observation, elective neck dissection or elective radiotherapy. Areas covered: We addressed the treatment options for cN0 patients with parotid gland cancer. A literature review was undertaken to determine the optimal management of this group of patients. Expert opinion: Patients with parotid carcinoma and clinically negative neck have various options for their management. The analysis of tumor stage, histology and grade is essential to better define patients at risk for occult lymph node metastasis. These patients can be managed by surgery, radiotherapy or their combination, depending on the presence of risk factors, the moment at which such risk factors are detected, patient-related clinical conditions, medical provider expertise and institutional facilities.

KW - elective neck treatment

KW - neck dissection

KW - parotid gland

KW - radiotherapy

KW - Salivary gland

UR - https://www.scopus.com/pages/publications/85073183472

U2 - 10.1080/14737140.2019.1674143

DO - 10.1080/14737140.2019.1674143

M3 - Review article

C2 - 31591950

AN - SCOPUS:85073183472

SN - 1473-7140

VL - 19

SP - 899

EP - 908

JO - Expert Review of Anticancer Therapy

JF - Expert Review of Anticancer Therapy

IS - 10

ER -

An evidence-based analysis of the management of N0 neck in patients with cancer of the parotid gland

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