An association study of debrisoquine hydroxylase (CYP2D6) polymorphisms in schizophrenia

E. Dawson; J. F. Powell; M. M. Nothen; M. A. Crocq; M. Lanczik; J. Korner; M. Rietschel; J. Van Os; P. Wright; M. Gill

doi:10.1097/00041444-199400440-00005

An association study of debrisoquine hydroxylase (CYP2D6) polymorphisms in schizophrenia

E. Dawson^*, J. F. Powell, M. M. Nothen, M. A. Crocq, M. Lanczik, J. Korner, M. Rietschel, J. Van Os, P. Wright, M. Gill

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

24 Citations (Scopus)

Abstract

The cytochrome P450 mono-oxygenases are a group of enzymes that metabolize a variety of exogenous and endogenous compounds, some of which are potentially toxic. Individual variations in the metabolism of potential toxins could influence susceptibility to disorders having genetic and environmental components, such as schizophrenia. The frequency of two common mutant alleles of the gene for the cytochrome P450 enzyme debrisoquine-4-hydroxylase (CYP2D6) was determined in 264 Caucasian schizophrenic patients and 217 controls, using the polymerase chain reaction and restriction enzyme digestions. The patient and control samples showed no significant deviation from Hardy-Weinberg equilibrium and the frequency of each mutant allele (CYP2D6A and CYP2D6B) did not differ between patients and controls.

Original language	English
Pages (from-to)	215-218
Number of pages	4
Journal	Psychiatric Genetics
Volume	4
Issue number	4
DOIs	https://doi.org/10.1097/00041444-199400440-00005
Publication status	Published - 1994
Externally published	Yes

Keywords

Association study
CYP2D6
Debrisoquine 4-Hydroxylase
Schizophrenia

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10.1097/00041444-199400440-00005

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title = "An association study of debrisoquine hydroxylase (CYP2D6) polymorphisms in schizophrenia",

abstract = "The cytochrome P450 mono-oxygenases are a group of enzymes that metabolize a variety of exogenous and endogenous compounds, some of which are potentially toxic. Individual variations in the metabolism of potential toxins could influence susceptibility to disorders having genetic and environmental components, such as schizophrenia. The frequency of two common mutant alleles of the gene for the cytochrome P450 enzyme debrisoquine-4-hydroxylase (CYP2D6) was determined in 264 Caucasian schizophrenic patients and 217 controls, using the polymerase chain reaction and restriction enzyme digestions. The patient and control samples showed no significant deviation from Hardy-Weinberg equilibrium and the frequency of each mutant allele (CYP2D6A and CYP2D6B) did not differ between patients and controls.",

keywords = "Association study, CYP2D6, Debrisoquine 4-Hydroxylase, Schizophrenia",

author = "E. Dawson and Powell, {J. F.} and Nothen, {M. M.} and Crocq, {M. A.} and M. Lanczik and J. Korner and M. Rietschel and {Van Os}, J. and P. Wright and M. Gill",

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doi = "10.1097/00041444-199400440-00005",

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T1 - An association study of debrisoquine hydroxylase (CYP2D6) polymorphisms in schizophrenia

AU - Dawson, E.

AU - Powell, J. F.

AU - Nothen, M. M.

AU - Crocq, M. A.

AU - Lanczik, M.

AU - Korner, J.

AU - Rietschel, M.

AU - Van Os, J.

AU - Wright, P.

AU - Gill, M.

PY - 1994

Y1 - 1994

N2 - The cytochrome P450 mono-oxygenases are a group of enzymes that metabolize a variety of exogenous and endogenous compounds, some of which are potentially toxic. Individual variations in the metabolism of potential toxins could influence susceptibility to disorders having genetic and environmental components, such as schizophrenia. The frequency of two common mutant alleles of the gene for the cytochrome P450 enzyme debrisoquine-4-hydroxylase (CYP2D6) was determined in 264 Caucasian schizophrenic patients and 217 controls, using the polymerase chain reaction and restriction enzyme digestions. The patient and control samples showed no significant deviation from Hardy-Weinberg equilibrium and the frequency of each mutant allele (CYP2D6A and CYP2D6B) did not differ between patients and controls.

AB - The cytochrome P450 mono-oxygenases are a group of enzymes that metabolize a variety of exogenous and endogenous compounds, some of which are potentially toxic. Individual variations in the metabolism of potential toxins could influence susceptibility to disorders having genetic and environmental components, such as schizophrenia. The frequency of two common mutant alleles of the gene for the cytochrome P450 enzyme debrisoquine-4-hydroxylase (CYP2D6) was determined in 264 Caucasian schizophrenic patients and 217 controls, using the polymerase chain reaction and restriction enzyme digestions. The patient and control samples showed no significant deviation from Hardy-Weinberg equilibrium and the frequency of each mutant allele (CYP2D6A and CYP2D6B) did not differ between patients and controls.

KW - Association study

KW - CYP2D6

KW - Debrisoquine 4-Hydroxylase

KW - Schizophrenia

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DO - 10.1097/00041444-199400440-00005

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ER -

An association study of debrisoquine hydroxylase (CYP2D6) polymorphisms in schizophrenia

Abstract

Keywords

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