An association of particulate air pollution and traffic exposure with mortality after lung transplantation in Europe

David Ruttens; Stijn E. Verleden; Esmée M. Bijnens; Ellen Winckelmans; Jens Gottlieb; Gregor Warnecke; Federica Meloni; Monica Morosini; Wim Van Der Bij; Erik A. Verschuuren; Urte Sommerwerck; Gerhard Weinreich; Markus Kamler; Antonio Roman; Susana Gomez-Olles; Cristina Berastegui; Christian Benden; Are Martin Holm; Martin Iversen; Hans Henrik Schultz; Bart Luijk; Erik Jan Oudijk; Johanna M. Kwakkel-Van Erp; Peter Jaksch; Walter Klepetko; Nikolaus Kneidinger; Claus Neurohr; Paul Corris; Andrew J. Fisher; James Lordan; Gerard Meachery; Davide Piloni; Elly Vandermeulen; Hannelore Bellon; Barbara Hoffmann; Danielle Vienneau; Gerard Hoek; Kees De Hoogh; Benoit Nemery; Geert M. Verleden; Robin Vos; Tim S. Nawrot; Bart M. Vanaudenaerde

doi:10.1183/13993003.00484-2016

An association of particulate air pollution and traffic exposure with mortality after lung transplantation in Europe

David Ruttens, Stijn E. Verleden, Esmée M. Bijnens, Ellen Winckelmans, Jens Gottlieb, Gregor Warnecke, Federica Meloni, Monica Morosini, Wim Van Der Bij, Erik A. Verschuuren, Urte Sommerwerck, Gerhard Weinreich, Markus Kamler, Antonio Roman, Susana Gomez-Olles, Cristina Berastegui, Christian Benden, Are Martin Holm, Martin Iversen, Hans Henrik SchultzBart Luijk, Erik Jan Oudijk, Johanna M. Kwakkel-Van Erp, Peter Jaksch, Walter Klepetko, Nikolaus Kneidinger, Claus Neurohr, Paul Corris, Andrew J. Fisher, James Lordan, Gerard Meachery, Davide Piloni, Elly Vandermeulen, Hannelore Bellon, Barbara Hoffmann, Danielle Vienneau, Gerard Hoek, Kees De Hoogh, Benoit Nemery, Geert M. Verleden, Robin Vos, Tim S. Nawrot, Bart M. Vanaudenaerde^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Air pollution from road traffic is a serious health risk, especially for susceptible individuals. Single-centre studies showed an association with chronic lung allograft dysfunction (CLAD) and survival after lung transplantation, but there are no large studies. 13 lung transplant centres in 10 European countries created a cohort of 5707 patients. For each patient, we quantified residential particulate matter with aerodynamic diameter ≤ 10 μm (PM10) by land use regression models, and the traffic exposure by quantifying total road length within buffer zones around the home addresses of patients and distance to a major road or freeway. After correction for macrolide use, we found associations between air pollution variables and CLAD/mortality. Given the important interaction with macrolides, we stratified according to macrolide use. No associations were observed in 2151 patients taking macrolides. However, in 3556 patients not taking macrolides, mortality was associated with PM10 (hazard ratio 1.081, 95% CI 1.000-1.167); similarly, CLAD and mortality were associated with road lengths in buffers of 200-1000 and 100-500 m, respectively (hazard ratio 1.085-1.130). Sensitivity analyses for various possible confounders confirmed the robustness of these associations. Long-term residential air pollution and traffic exposure were associated with CLAD and survival after lung transplantation, but only in patients not taking macrolides.

Original language	English
Journal	European Respiratory Journal
Volume	49
Issue number	1
DOIs	https://doi.org/10.1183/13993003.00484-2016
Publication status	Published - 2016

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Ruttens, D., Verleden, S. E., Bijnens, E. M., Winckelmans, E., Gottlieb, J., Warnecke, G., Meloni, F., Morosini, M., Van Der Bij, W., Verschuuren, E. A., Sommerwerck, U., Weinreich, G., Kamler, M., Roman, A., Gomez-Olles, S., Berastegui, C., Benden, C., Holm, A. M., Iversen, M., ... Vanaudenaerde, B. M. (2016). An association of particulate air pollution and traffic exposure with mortality after lung transplantation in Europe. European Respiratory Journal, 49(1). https://doi.org/10.1183/13993003.00484-2016

@article{1e3603affc974821a115535f69929e45,

title = "An association of particulate air pollution and traffic exposure with mortality after lung transplantation in Europe",

abstract = "Air pollution from road traffic is a serious health risk, especially for susceptible individuals. Single-centre studies showed an association with chronic lung allograft dysfunction (CLAD) and survival after lung transplantation, but there are no large studies. 13 lung transplant centres in 10 European countries created a cohort of 5707 patients. For each patient, we quantified residential particulate matter with aerodynamic diameter ≤ 10 μm (PM10) by land use regression models, and the traffic exposure by quantifying total road length within buffer zones around the home addresses of patients and distance to a major road or freeway. After correction for macrolide use, we found associations between air pollution variables and CLAD/mortality. Given the important interaction with macrolides, we stratified according to macrolide use. No associations were observed in 2151 patients taking macrolides. However, in 3556 patients not taking macrolides, mortality was associated with PM10 (hazard ratio 1.081, 95% CI 1.000-1.167); similarly, CLAD and mortality were associated with road lengths in buffers of 200-1000 and 100-500 m, respectively (hazard ratio 1.085-1.130). Sensitivity analyses for various possible confounders confirmed the robustness of these associations. Long-term residential air pollution and traffic exposure were associated with CLAD and survival after lung transplantation, but only in patients not taking macrolides.",

author = "David Ruttens and Verleden, {Stijn E.} and Bijnens, {Esm{\'e}e M.} and Ellen Winckelmans and Jens Gottlieb and Gregor Warnecke and Federica Meloni and Monica Morosini and {Van Der Bij}, Wim and Verschuuren, {Erik A.} and Urte Sommerwerck and Gerhard Weinreich and Markus Kamler and Antonio Roman and Susana Gomez-Olles and Cristina Berastegui and Christian Benden and Holm, {Are Martin} and Martin Iversen and Schultz, {Hans Henrik} and Bart Luijk and Oudijk, {Erik Jan} and {Kwakkel-Van Erp}, {Johanna M.} and Peter Jaksch and Walter Klepetko and Nikolaus Kneidinger and Claus Neurohr and Paul Corris and Fisher, {Andrew J.} and James Lordan and Gerard Meachery and Davide Piloni and Elly Vandermeulen and Hannelore Bellon and Barbara Hoffmann and Danielle Vienneau and Gerard Hoek and {De Hoogh}, Kees and Benoit Nemery and Verleden, {Geert M.} and Robin Vos and Nawrot, {Tim S.} and Vanaudenaerde, {Bart M.}",

note = "Publisher Copyright: Copyright {\textcopyright} ERS 2016.",

year = "2016",

doi = "10.1183/13993003.00484-2016",

language = "English",

volume = "49",

journal = "European Respiratory Journal",

issn = "0903-1936",

publisher = "European Respiratory Society",

number = "1",

}

Ruttens, D, Verleden, SE, Bijnens, EM, Winckelmans, E, Gottlieb, J, Warnecke, G, Meloni, F, Morosini, M, Van Der Bij, W, Verschuuren, EA, Sommerwerck, U, Weinreich, G, Kamler, M, Roman, A, Gomez-Olles, S, Berastegui, C, Benden, C, Holm, AM, Iversen, M, Schultz, HH, Luijk, B, Oudijk, EJ, Kwakkel-Van Erp, JM, Jaksch, P, Klepetko, W, Kneidinger, N, Neurohr, C, Corris, P, Fisher, AJ, Lordan, J, Meachery, G, Piloni, D, Vandermeulen, E, Bellon, H, Hoffmann, B, Vienneau, D, Hoek, G, De Hoogh, K, Nemery, B, Verleden, GM, Vos, R, Nawrot, TS & Vanaudenaerde, BM 2016, 'An association of particulate air pollution and traffic exposure with mortality after lung transplantation in Europe', European Respiratory Journal, vol. 49, no. 1. https://doi.org/10.1183/13993003.00484-2016

TY - JOUR

T1 - An association of particulate air pollution and traffic exposure with mortality after lung transplantation in Europe

AU - Ruttens, David

AU - Verleden, Stijn E.

AU - Bijnens, Esmée M.

AU - Winckelmans, Ellen

AU - Gottlieb, Jens

AU - Warnecke, Gregor

AU - Meloni, Federica

AU - Morosini, Monica

AU - Van Der Bij, Wim

AU - Verschuuren, Erik A.

AU - Sommerwerck, Urte

AU - Weinreich, Gerhard

AU - Kamler, Markus

AU - Roman, Antonio

AU - Gomez-Olles, Susana

AU - Berastegui, Cristina

AU - Benden, Christian

AU - Holm, Are Martin

AU - Iversen, Martin

AU - Schultz, Hans Henrik

AU - Luijk, Bart

AU - Oudijk, Erik Jan

AU - Kwakkel-Van Erp, Johanna M.

AU - Jaksch, Peter

AU - Klepetko, Walter

AU - Kneidinger, Nikolaus

AU - Neurohr, Claus

AU - Corris, Paul

AU - Fisher, Andrew J.

AU - Lordan, James

AU - Meachery, Gerard

AU - Piloni, Davide

AU - Vandermeulen, Elly

AU - Bellon, Hannelore

AU - Hoffmann, Barbara

AU - Vienneau, Danielle

AU - Hoek, Gerard

AU - De Hoogh, Kees

AU - Nemery, Benoit

AU - Verleden, Geert M.

AU - Vos, Robin

AU - Nawrot, Tim S.

AU - Vanaudenaerde, Bart M.

PY - 2016

Y1 - 2016

N2 - Air pollution from road traffic is a serious health risk, especially for susceptible individuals. Single-centre studies showed an association with chronic lung allograft dysfunction (CLAD) and survival after lung transplantation, but there are no large studies. 13 lung transplant centres in 10 European countries created a cohort of 5707 patients. For each patient, we quantified residential particulate matter with aerodynamic diameter ≤ 10 μm (PM10) by land use regression models, and the traffic exposure by quantifying total road length within buffer zones around the home addresses of patients and distance to a major road or freeway. After correction for macrolide use, we found associations between air pollution variables and CLAD/mortality. Given the important interaction with macrolides, we stratified according to macrolide use. No associations were observed in 2151 patients taking macrolides. However, in 3556 patients not taking macrolides, mortality was associated with PM10 (hazard ratio 1.081, 95% CI 1.000-1.167); similarly, CLAD and mortality were associated with road lengths in buffers of 200-1000 and 100-500 m, respectively (hazard ratio 1.085-1.130). Sensitivity analyses for various possible confounders confirmed the robustness of these associations. Long-term residential air pollution and traffic exposure were associated with CLAD and survival after lung transplantation, but only in patients not taking macrolides.

AB - Air pollution from road traffic is a serious health risk, especially for susceptible individuals. Single-centre studies showed an association with chronic lung allograft dysfunction (CLAD) and survival after lung transplantation, but there are no large studies. 13 lung transplant centres in 10 European countries created a cohort of 5707 patients. For each patient, we quantified residential particulate matter with aerodynamic diameter ≤ 10 μm (PM10) by land use regression models, and the traffic exposure by quantifying total road length within buffer zones around the home addresses of patients and distance to a major road or freeway. After correction for macrolide use, we found associations between air pollution variables and CLAD/mortality. Given the important interaction with macrolides, we stratified according to macrolide use. No associations were observed in 2151 patients taking macrolides. However, in 3556 patients not taking macrolides, mortality was associated with PM10 (hazard ratio 1.081, 95% CI 1.000-1.167); similarly, CLAD and mortality were associated with road lengths in buffers of 200-1000 and 100-500 m, respectively (hazard ratio 1.085-1.130). Sensitivity analyses for various possible confounders confirmed the robustness of these associations. Long-term residential air pollution and traffic exposure were associated with CLAD and survival after lung transplantation, but only in patients not taking macrolides.

UR - http://www.scopus.com/inward/record.url?scp=85017023847&partnerID=8YFLogxK

U2 - 10.1183/13993003.00484-2016

DO - 10.1183/13993003.00484-2016

M3 - Article

C2 - 27836956

AN - SCOPUS:85017023847

SN - 0903-1936

VL - 49

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - 1

ER -

An association of particulate air pollution and traffic exposure with mortality after lung transplantation in Europe

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