TY - JOUR
T1 - Amyotrophic lateral sclerosis
AU - van Es, Michael A.
AU - Hardiman, Orla
AU - Chio, Adriano
AU - Al-Chalabi, Ammar
AU - Pasterkamp, R. Jeroen
AU - Veldink, Jan H.
AU - van den Berg, Leonard H.
N1 - Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/11/4
Y1 - 2017/11/4
N2 - Amyotrophic lateral sclerosis is characterised by the progressive loss of motor neurons in the brain and spinal cord. This neurodegenerative syndrome shares pathobiological features with frontotemporal dementia and, indeed, many patients show features of both diseases. Many different genes and pathophysiological processes contribute to the disease, and it will be necessary to understand this heterogeneity to find effective treatments. In this Seminar, we discuss clinical and diagnostic approaches as well as scientific advances in the research fields of genetics, disease modelling, biomarkers, and therapeutic strategies.
AB - Amyotrophic lateral sclerosis is characterised by the progressive loss of motor neurons in the brain and spinal cord. This neurodegenerative syndrome shares pathobiological features with frontotemporal dementia and, indeed, many patients show features of both diseases. Many different genes and pathophysiological processes contribute to the disease, and it will be necessary to understand this heterogeneity to find effective treatments. In this Seminar, we discuss clinical and diagnostic approaches as well as scientific advances in the research fields of genetics, disease modelling, biomarkers, and therapeutic strategies.
UR - http://www.scopus.com/inward/record.url?scp=85019945045&partnerID=8YFLogxK
U2 - 10.1016/S0140-6736(17)31287-4
DO - 10.1016/S0140-6736(17)31287-4
M3 - Review article
C2 - 28552366
SN - 0140-6736
VL - 390
SP - 2084
EP - 2098
JO - The Lancet
JF - The Lancet
IS - 10107
ER -