Amyloid and its association with default network integrity in Alzheimer's disease

Sofie M Adriaanse; Ernesto J Sanz-Arigita; Maja A A Binnewijzend; Rik Ossenkoppele; Nelleke Tolboom; Daniëlle M E van Assema; Alle Meije Wink; Ronald Boellaard; Maqsood Yaqub; Albert D Windhorst; Wiesje M van der Flier; Philip Scheltens; Adriaan A Lammertsma; Serge A R B Rombouts; Frederik Barkhof; Bart N M van Berckel

doi:10.1002/hbm.22213

Amyloid and its association with default network integrity in Alzheimer's disease

Sofie M Adriaanse^*, Ernesto J Sanz-Arigita, Maja A A Binnewijzend, Rik Ossenkoppele, Nelleke Tolboom, Daniëlle M E van Assema, Alle Meije Wink, Ronald Boellaard, Maqsood Yaqub, Albert D Windhorst, Wiesje M van der Flier, Philip Scheltens, Adriaan A Lammertsma, Serge A R B Rombouts, Frederik Barkhof, Bart N M van Berckel

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The purpose of this study was to investigate the association between functional connectivity and β-amyloid depositions in the default mode network (DMN) in Alzheimer's disease (AD), patients with mild cognitive impairment (MCI), and healthy elderly. Twenty-five patients with AD, 12 patients with MCI, and 18 healthy controls were included in the study. Resting-state functional magnetic resonance imaging was used to assess functional connectivity in the DMN. In parallel, amyloid burden was measured in the same subjects using positron emission tomography with carbon-11-labeled Pittsburgh Compound-B as amyloid tracer. Functional connectivity of the DMN and amyloid deposition within the DMN were not associated across all subjects or within diagnostic groups. Longitudinal studies are needed to examine if amyloid depositions precede aberrant functional connectivity in the DMN.

Original language	English
Pages (from-to)	779-91
Number of pages	13
Journal	Human Brain Mapping
Volume	35
Issue number	3
DOIs	https://doi.org/10.1002/hbm.22213
Publication status	Published - Mar 2014
Externally published	Yes

Keywords

Aged
Aging/metabolism
Alzheimer Disease/metabolism
Amyloid beta-Peptides/metabolism
Aniline Compounds
Brain/metabolism
Cognitive Dysfunction/metabolism
Female
Functional Neuroimaging/instrumentation
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Nerve Net/metabolism
Positron-Emission Tomography/instrumentation
Thiazoles

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10.1002/hbm.22213

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Adriaanse, S. M., Sanz-Arigita, E. J., Binnewijzend, M. A. A., Ossenkoppele, R., Tolboom, N., van Assema, D. M. E., Wink, A. M., Boellaard, R., Yaqub, M., Windhorst, A. D., van der Flier, W. M., Scheltens, P., Lammertsma, A. A., Rombouts, S. A. R. B., Barkhof, F., & van Berckel, B. N. M. (2014). Amyloid and its association with default network integrity in Alzheimer's disease. Human Brain Mapping, 35(3), 779-91. https://doi.org/10.1002/hbm.22213

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title = "Amyloid and its association with default network integrity in Alzheimer's disease",

abstract = "The purpose of this study was to investigate the association between functional connectivity and β-amyloid depositions in the default mode network (DMN) in Alzheimer's disease (AD), patients with mild cognitive impairment (MCI), and healthy elderly. Twenty-five patients with AD, 12 patients with MCI, and 18 healthy controls were included in the study. Resting-state functional magnetic resonance imaging was used to assess functional connectivity in the DMN. In parallel, amyloid burden was measured in the same subjects using positron emission tomography with carbon-11-labeled Pittsburgh Compound-B as amyloid tracer. Functional connectivity of the DMN and amyloid deposition within the DMN were not associated across all subjects or within diagnostic groups. Longitudinal studies are needed to examine if amyloid depositions precede aberrant functional connectivity in the DMN.",

keywords = "Aged, Aging/metabolism, Alzheimer Disease/metabolism, Amyloid beta-Peptides/metabolism, Aniline Compounds, Brain/metabolism, Cognitive Dysfunction/metabolism, Female, Functional Neuroimaging/instrumentation, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net/metabolism, Positron-Emission Tomography/instrumentation, Thiazoles",

author = "Adriaanse, {Sofie M} and Sanz-Arigita, {Ernesto J} and Binnewijzend, {Maja A A} and Rik Ossenkoppele and Nelleke Tolboom and {van Assema}, {Dani{\"e}lle M E} and Wink, {Alle Meije} and Ronald Boellaard and Maqsood Yaqub and Windhorst, {Albert D} and {van der Flier}, {Wiesje M} and Philip Scheltens and Lammertsma, {Adriaan A} and Rombouts, {Serge A R B} and Frederik Barkhof and {van Berckel}, {Bart N M}",

note = "Copyright {\textcopyright} 2012 Wiley Periodicals, Inc.",

year = "2014",

month = mar,

doi = "10.1002/hbm.22213",

language = "English",

volume = "35",

pages = "779--91",

journal = "Human Brain Mapping",

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Adriaanse, SM, Sanz-Arigita, EJ, Binnewijzend, MAA, Ossenkoppele, R, Tolboom, N, van Assema, DME, Wink, AM, Boellaard, R, Yaqub, M, Windhorst, AD, van der Flier, WM, Scheltens, P, Lammertsma, AA, Rombouts, SARB, Barkhof, F & van Berckel, BNM 2014, 'Amyloid and its association with default network integrity in Alzheimer's disease', Human Brain Mapping, vol. 35, no. 3, pp. 779-91. https://doi.org/10.1002/hbm.22213

TY - JOUR

T1 - Amyloid and its association with default network integrity in Alzheimer's disease

AU - Adriaanse, Sofie M

AU - Sanz-Arigita, Ernesto J

AU - Binnewijzend, Maja A A

AU - Ossenkoppele, Rik

AU - Tolboom, Nelleke

AU - van Assema, Daniëlle M E

AU - Wink, Alle Meije

AU - Boellaard, Ronald

AU - Yaqub, Maqsood

AU - Windhorst, Albert D

AU - van der Flier, Wiesje M

AU - Scheltens, Philip

AU - Lammertsma, Adriaan A

AU - Rombouts, Serge A R B

AU - Barkhof, Frederik

AU - van Berckel, Bart N M

PY - 2014/3

Y1 - 2014/3

N2 - The purpose of this study was to investigate the association between functional connectivity and β-amyloid depositions in the default mode network (DMN) in Alzheimer's disease (AD), patients with mild cognitive impairment (MCI), and healthy elderly. Twenty-five patients with AD, 12 patients with MCI, and 18 healthy controls were included in the study. Resting-state functional magnetic resonance imaging was used to assess functional connectivity in the DMN. In parallel, amyloid burden was measured in the same subjects using positron emission tomography with carbon-11-labeled Pittsburgh Compound-B as amyloid tracer. Functional connectivity of the DMN and amyloid deposition within the DMN were not associated across all subjects or within diagnostic groups. Longitudinal studies are needed to examine if amyloid depositions precede aberrant functional connectivity in the DMN.

AB - The purpose of this study was to investigate the association between functional connectivity and β-amyloid depositions in the default mode network (DMN) in Alzheimer's disease (AD), patients with mild cognitive impairment (MCI), and healthy elderly. Twenty-five patients with AD, 12 patients with MCI, and 18 healthy controls were included in the study. Resting-state functional magnetic resonance imaging was used to assess functional connectivity in the DMN. In parallel, amyloid burden was measured in the same subjects using positron emission tomography with carbon-11-labeled Pittsburgh Compound-B as amyloid tracer. Functional connectivity of the DMN and amyloid deposition within the DMN were not associated across all subjects or within diagnostic groups. Longitudinal studies are needed to examine if amyloid depositions precede aberrant functional connectivity in the DMN.

KW - Aged

KW - Aging/metabolism

KW - Alzheimer Disease/metabolism

KW - Amyloid beta-Peptides/metabolism

KW - Aniline Compounds

KW - Brain/metabolism

KW - Cognitive Dysfunction/metabolism

KW - Female

KW - Functional Neuroimaging/instrumentation

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Nerve Net/metabolism

KW - Positron-Emission Tomography/instrumentation

KW - Thiazoles

U2 - 10.1002/hbm.22213

DO - 10.1002/hbm.22213

M3 - Article

C2 - 23238869

SN - 1065-9471

VL - 35

SP - 779

EP - 791

JO - Human Brain Mapping

JF - Human Brain Mapping

IS - 3

ER -

Amyloid and its association with default network integrity in Alzheimer's disease

Abstract

Keywords

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