TY - JOUR
T1 - Ambient Air Pollution and Adult Asthma Incidence in Six European Cohorts (ESCAPE)
AU - Jacquemin, B.
AU - Siroux, V.
AU - Sanchez, M.
AU - Carsin, A. E.
AU - Schikowski, T.
AU - Adam, M.
AU - Bellisario, V.
AU - Buschka, A.
AU - Bono, R.
AU - Brunekreef, B.
AU - Cai, Y.
AU - Cirach, M.
AU - Clavel-Chapelon, F.
AU - Declercq, C.
AU - de Marco, R.
AU - de Nazelle, A.
AU - Ducret-Stich, R. E.
AU - Ferretti, V. V.
AU - Gerbase, M. W.
AU - Hardy, R.
AU - Heinrich, J.
AU - Janson, C.
AU - Jarvis, D.
AU - Al Kanaani, Z.
AU - Keidel, D.
AU - Kuh, D.
AU - Le Moual, N.
AU - Nieuwenhuijsen, M. J.
AU - Marcon, A.
AU - Modig, L.
AU - Pin, I.
AU - Rochat, T.
AU - Schindler, C.
AU - Sugiri, D.
AU - Stempfelet, M.
AU - Temam, S.
AU - Tsai, M. Y.
AU - Varraso, R.
AU - Vienneau, D.
AU - Vierkotter, A.
AU - Hansell, A. L.
AU - Kramer, U.
AU - Probst-Hensch, N. M.
AU - Sunyer, J.
AU - Kunzli, N.
AU - Kauffmann, F.
N1 - Jacquemin, Benedicte Siroux, Valerie Sanchez, Margaux Carsin, Anne-Elie Schikowski, Tamara Adam, Martin Bellisario, Valeria Buschka, Anna Bono, Roberto Brunekreef, Bert Cai, Yutong Cirach, Marta Clavel-Chapelon, Francoise Declercq, Christophe de Marco, Roberto de Nazelle, Audrey Ducret-Stich, Regina E Ferretti, Virginia Valeria Gerbase, Margaret W Hardy, Rebecca Heinrich, Joachim Janson, Christer Jarvis, Deborah Al Kanaani, Zaina Keidel, Dirk Kuh, Diana Le Moual, Nicole Nieuwenhuijsen, Mark J Marcon, Alessandro Modig, Lars Pin, Isabelle Rochat, Thierry Schindler, Christian Sugiri, Dorothea Stempfelet, Morgane Temam, Sofia Tsai, Ming-Yi Varraso, Raphaelle Vienneau, Danielle Vierkotter, Andrea Hansell, Anna L Kramer, Ursula Probst-Hensch, Nicole M Sunyer, Jordi Kunzli, Nino Kauffmann, Francine United States Environ Health Perspect. 2015 Jun;123(6):613-21. doi: 10.1289/ehp.1408206. Epub 2015 Feb 24.
PY - 2015
Y1 - 2015
N2 - BACKGROUND: Short-term exposure to air pollution has adverse effects among patients with asthma, but whether long-term exposure to air pollution is a cause of adult-onset asthma is unclear. OBJECTIVE: We aimed to investigate the association between air pollution and adult onset asthma. METHODS: Asthma incidence was prospectively assessed in six European cohorts. Exposures studied were annual average concentrations at home addresses for nitrogen oxides assessed for 23,704 participants (including 1,257 incident cases) and particulate matter (PM) assessed for 17,909 participants through ESCAPE land-use regression models and traffic exposure indicators. Meta-analyses of cohort-specific logistic regression on asthma incidence were performed. Models were adjusted for age, sex, overweight, education, and smoking and included city/area within each cohort as a random effect. RESULTS: In this longitudinal analysis, asthma incidence was positively, but not significantly, associated with all exposure metrics, except for PMcoarse. Positive associations of borderline significance were observed for nitrogen dioxide [adjusted odds ratio (OR) = 1.10; 95% CI: 0.99, 1.21 per 10 mug/m3; p = 0.10] and nitrogen oxides (adjusted OR = 1.04; 95% CI: 0.99, 1.08 per 20 mug/m3; p = 0.08). Nonsignificant positive associations were estimated for PM10 (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 10 mug/m3), PM2.5 (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 5 mug/m3), PM2.5absorbance (adjusted OR = 1.06; 95% CI: 0.95, 1.19 per 10-5/m), traffic load (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 4 million vehicles x meters/day on major roads in a 100-m buffer), and traffic intensity (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 5,000 vehicles/day on the nearest road). A nonsignificant negative association was estimated for PMcoarse (adjusted OR = 0.98; 95% CI: 0.87, 1.14 per 5 mug/m3). CONCLUSIONS: Results suggest a deleterious effect of ambient air pollution on asthma incidence in adults. Further research with improved personal-level exposure assessment (vs. residential exposure assessment only) and phenotypic characterization is needed. CITATION: Jacquemin B, Siroux V, Sanchez M, Carsin AE, Schikowski T, Adam M, Bellisario V, Buschka A, Bono R, Brunekreef B, Cai Y, Cirach M, Clavel-Chapelon F, Declercq C, de Marco R, de Nazelle A, Ducret-Stich RE, Ferretti VV, Gerbase MW, Hardy R, Heinrich J, Janson C, Jarvis D, Al Kanaani Z, Keidel D, Kuh D, Le Moual N, Nieuwenhuijsen MJ, Marcon A, Modig L, Pin I, Rochat T, Schindler C, Sugiri D, Stempfelet M, Temam S, Tsai MY, Varraso R, Vienneau D, Vierkotter A, Hansell AL, Kramer U, Probst-Hensch NM, Sunyer J, Kunzli N, Kauffmann F. 2015. Ambient air pollution and adult asthma incidence in six European cohorts (ESCAPE). Environ Health Perspect 123:613-621; http://dx.doi.org/10.1289/ehp.1408206.
AB - BACKGROUND: Short-term exposure to air pollution has adverse effects among patients with asthma, but whether long-term exposure to air pollution is a cause of adult-onset asthma is unclear. OBJECTIVE: We aimed to investigate the association between air pollution and adult onset asthma. METHODS: Asthma incidence was prospectively assessed in six European cohorts. Exposures studied were annual average concentrations at home addresses for nitrogen oxides assessed for 23,704 participants (including 1,257 incident cases) and particulate matter (PM) assessed for 17,909 participants through ESCAPE land-use regression models and traffic exposure indicators. Meta-analyses of cohort-specific logistic regression on asthma incidence were performed. Models were adjusted for age, sex, overweight, education, and smoking and included city/area within each cohort as a random effect. RESULTS: In this longitudinal analysis, asthma incidence was positively, but not significantly, associated with all exposure metrics, except for PMcoarse. Positive associations of borderline significance were observed for nitrogen dioxide [adjusted odds ratio (OR) = 1.10; 95% CI: 0.99, 1.21 per 10 mug/m3; p = 0.10] and nitrogen oxides (adjusted OR = 1.04; 95% CI: 0.99, 1.08 per 20 mug/m3; p = 0.08). Nonsignificant positive associations were estimated for PM10 (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 10 mug/m3), PM2.5 (adjusted OR = 1.04; 95% CI: 0.88, 1.23 per 5 mug/m3), PM2.5absorbance (adjusted OR = 1.06; 95% CI: 0.95, 1.19 per 10-5/m), traffic load (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 4 million vehicles x meters/day on major roads in a 100-m buffer), and traffic intensity (adjusted OR = 1.10; 95% CI: 0.93, 1.30 per 5,000 vehicles/day on the nearest road). A nonsignificant negative association was estimated for PMcoarse (adjusted OR = 0.98; 95% CI: 0.87, 1.14 per 5 mug/m3). CONCLUSIONS: Results suggest a deleterious effect of ambient air pollution on asthma incidence in adults. Further research with improved personal-level exposure assessment (vs. residential exposure assessment only) and phenotypic characterization is needed. CITATION: Jacquemin B, Siroux V, Sanchez M, Carsin AE, Schikowski T, Adam M, Bellisario V, Buschka A, Bono R, Brunekreef B, Cai Y, Cirach M, Clavel-Chapelon F, Declercq C, de Marco R, de Nazelle A, Ducret-Stich RE, Ferretti VV, Gerbase MW, Hardy R, Heinrich J, Janson C, Jarvis D, Al Kanaani Z, Keidel D, Kuh D, Le Moual N, Nieuwenhuijsen MJ, Marcon A, Modig L, Pin I, Rochat T, Schindler C, Sugiri D, Stempfelet M, Temam S, Tsai MY, Varraso R, Vienneau D, Vierkotter A, Hansell AL, Kramer U, Probst-Hensch NM, Sunyer J, Kunzli N, Kauffmann F. 2015. Ambient air pollution and adult asthma incidence in six European cohorts (ESCAPE). Environ Health Perspect 123:613-621; http://dx.doi.org/10.1289/ehp.1408206.
U2 - 10.1289/ehp.1408206
DO - 10.1289/ehp.1408206
M3 - Article
SN - 1552-9924
VL - 123
SP - 613
EP - 621
JO - Environmental health perspectives
JF - Environmental health perspectives
IS - 6
ER -