TY - JOUR
T1 - Always on the Move
T2 - Overview on Chromatin Dynamics within Nuclear Processes
AU - Delvaux de Fenffe, Charlotte M
AU - Govers, Jolijn
AU - Mattiroli, Francesca
N1 - Publisher Copyright:
© 2025 The Authors. Published by American Chemical Society.
PY - 2025/5/20
Y1 - 2025/5/20
N2 - Our genome is organized into chromatin, a dynamic and modular structure made of nucleosomes. Chromatin organization controls access to the DNA sequence, playing a fundamental role in cell identity and function. How nucleosomes enable these processes is an active area of study. In this review, we provide an overview of chromatin dynamics, its properties, mechanisms, and functions. We highlight the diverse ways by which chromatin dynamics is controlled during transcription, DNA replication, and repair. Recent technological developments have promoted discoveries in this area, to which we provide an outlook on future research directions.
AB - Our genome is organized into chromatin, a dynamic and modular structure made of nucleosomes. Chromatin organization controls access to the DNA sequence, playing a fundamental role in cell identity and function. How nucleosomes enable these processes is an active area of study. In this review, we provide an overview of chromatin dynamics, its properties, mechanisms, and functions. We highlight the diverse ways by which chromatin dynamics is controlled during transcription, DNA replication, and repair. Recent technological developments have promoted discoveries in this area, to which we provide an outlook on future research directions.
KW - chromatin dynamics
KW - nucleosome
KW - DNA sequence
KW - chromatin organization
UR - https://www.scopus.com/pages/publications/105004051548
U2 - 10.1021/acs.biochem.5c00114
DO - 10.1021/acs.biochem.5c00114
M3 - Review article
C2 - 40312022
SN - 0006-2960
VL - 64
SP - 2138
EP - 2153
JO - Biochemistry
JF - Biochemistry
IS - 10
ER -