Alterations in regulatory T cells induced by specific oligosaccharides improve vaccine responsiveness in mice.

M.A. Schijf; J. Kerperien; J. Bastiaans; K. Szklany; J. Meerding; G.A. Hofman; L Boon; F. van Wijk; J. Garssen; B. van 't Land

Alterations in regulatory T cells induced by specific oligosaccharides improve vaccine responsiveness in mice.

Translated title of the contribution: Alterations in regulatory T cells induced by specific oligosaccharides improve vaccine responsiveness in mice.

M.A. Schijf, J. Kerperien, J. Bastiaans, K. Szklany, J. Meerding, G.A. Hofman, L Boon, F. van Wijk, J. Garssen, B. van 't Land

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Prophylactic vaccinations are generally performed to protect naive individuals with or without suppressed immune responsiveness. In a mouse model for Influenza vaccinations the specific alterations of CD4(+)CD25(+)Foxp3(+) regulatory T-cells (Tregs) in the immune modulation induced by orally supplied oligosaccharides containing scGOS/lcFOS/pAOS was assessed. This dietary intervention increased vaccine specific DTH responses. In addition, a significant increased percentage of T-bet(+) (Th1) activated CD69(+)CD4(+) T cells (p

Translated title of the contribution	Alterations in regulatory T cells induced by specific oligosaccharides improve vaccine responsiveness in mice.
Original language	Undefined/Unknown
Article number	e75148
Pages (from-to)	e75148
Number of pages	1
Journal	PLoS ONE [E]
Volume	8
Issue number	9
Publication status	Published - 2013

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title = "Alterations in regulatory T cells induced by specific oligosaccharides improve vaccine responsiveness in mice.",

abstract = "Prophylactic vaccinations are generally performed to protect naive individuals with or without suppressed immune responsiveness. In a mouse model for Influenza vaccinations the specific alterations of CD4(+)CD25(+)Foxp3(+) regulatory T-cells (Tregs) in the immune modulation induced by orally supplied oligosaccharides containing scGOS/lcFOS/pAOS was assessed. This dietary intervention increased vaccine specific DTH responses. In addition, a significant increased percentage of T-bet(+) (Th1) activated CD69(+)CD4(+) T cells (p",

author = "M.A. Schijf and J. Kerperien and J. Bastiaans and K. Szklany and J. Meerding and G.A. Hofman and L Boon and {van Wijk}, F. and J. Garssen and {van 't Land}, B.",

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T1 - Alterations in regulatory T cells induced by specific oligosaccharides improve vaccine responsiveness in mice.

AU - Schijf, M.A.

AU - Kerperien, J.

AU - Bastiaans, J.

AU - Szklany, K.

AU - Meerding, J.

AU - Hofman, G.A.

AU - Boon, L

AU - van Wijk, F.

AU - Garssen, J.

AU - van 't Land, B.

PY - 2013

Y1 - 2013

N2 - Prophylactic vaccinations are generally performed to protect naive individuals with or without suppressed immune responsiveness. In a mouse model for Influenza vaccinations the specific alterations of CD4(+)CD25(+)Foxp3(+) regulatory T-cells (Tregs) in the immune modulation induced by orally supplied oligosaccharides containing scGOS/lcFOS/pAOS was assessed. This dietary intervention increased vaccine specific DTH responses. In addition, a significant increased percentage of T-bet(+) (Th1) activated CD69(+)CD4(+) T cells (p

AB - Prophylactic vaccinations are generally performed to protect naive individuals with or without suppressed immune responsiveness. In a mouse model for Influenza vaccinations the specific alterations of CD4(+)CD25(+)Foxp3(+) regulatory T-cells (Tregs) in the immune modulation induced by orally supplied oligosaccharides containing scGOS/lcFOS/pAOS was assessed. This dietary intervention increased vaccine specific DTH responses. In addition, a significant increased percentage of T-bet(+) (Th1) activated CD69(+)CD4(+) T cells (p

M3 - Article

SN - 1932-6203

VL - 8

SP - e75148

JO - PLoS ONE [E]

JF - PLoS ONE [E]

IS - 9

M1 - e75148

ER -

Alterations in regulatory T cells induced by specific oligosaccharides improve vaccine responsiveness in mice.

Abstract

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