TY - JOUR
T1 - Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT)
T2 - protocol for a multicentre randomised controlled trial
AU - Neerland, Bjørn Erik
AU - Busund, Rolf
AU - Haaverstad, Rune
AU - Helbostad, Jorunn L
AU - Landsverk, Svein Aslak
AU - Martinaityte, Ieva
AU - Norum, Hilde Margrethe
AU - Ræder, Johan
AU - Selbaek, Geir
AU - Simpson, Melanie R
AU - Skaar, Elisabeth
AU - Skjærvold, Nils Kristian
AU - Skovlund, Eva
AU - Slooter, Arjen Jc
AU - Svendsen, Øyvind Sverre
AU - Tønnessen, Theis
AU - Wahba, Alexander
AU - Zetterberg, Henrik
AU - Wyller, Torgeir Bruun
N1 - Funding Information:
The trial is funded by KLINBEFORSK, The National Programme for Clinical Therapy Research in the Specialist Health Service in Norway, grant number 2020204. HZ is a Wallenberg Scholar.
Publisher Copyright:
© 2022 BMJ Publishing Group. All rights reserved.
PY - 2022/6/20
Y1 - 2022/6/20
N2 - INTRODUCTION: Postoperative delirium is common in older cardiac surgery patients and associated with negative short-term and long-term outcomes. The alpha-2-adrenergic receptor agonist dexmedetomidine shows promise as prophylaxis and treatment for delirium in intensive care units (ICU) and postoperative settings. Clonidine has similar pharmacological properties and can be administered both parenterally and orally. We aim to study whether repurposing of clonidine can represent a novel treatment option for delirium, and the possible effects of dexmedetomidine and clonidine on long-term cognitive trajectories, motor activity patterns and biomarkers of neuronal injury, and whether these effects are associated with frailty status.METHODS AND ANALYSIS: This five-centre, double-blind randomised controlled trial will include 900 cardiac surgery patients aged 70+ years. Participants will be randomised 1:1:1 to dexmedetomidine or clonidine or placebo. The study drug will be given as a continuous intravenous infusion from the start of cardiopulmonary bypass, at a rate of 0.4 µg/kg/hour. The infusion rate will be decreased to 0.2 µg/kg/hour postoperatively and be continued until discharge from the ICU or 24 hours postoperatively, whichever happens first.Primary end point is the 7-day cumulative incidence of postoperative delirium (Diagnostic and Statistical Manual of Mental Disorders, fifth edition). Secondary end points include the composite end point of coma, delirium or death, in addition to delirium severity and motor activity patterns, levels of circulating biomarkers of neuronal injury, cognitive function and frailty status 1 and 6 months after surgery.ETHICS AND DISSEMINATION: This trial is approved by the Regional Committee for Ethics in Medical Research in Norway (South-East Norway) and by the Norwegian Medicines Agency. Dissemination plans include publication in peer-reviewed medical journals and presentation at scientific meetings.TRIAL REGISTRATION NUMBER: NCT05029050.
AB - INTRODUCTION: Postoperative delirium is common in older cardiac surgery patients and associated with negative short-term and long-term outcomes. The alpha-2-adrenergic receptor agonist dexmedetomidine shows promise as prophylaxis and treatment for delirium in intensive care units (ICU) and postoperative settings. Clonidine has similar pharmacological properties and can be administered both parenterally and orally. We aim to study whether repurposing of clonidine can represent a novel treatment option for delirium, and the possible effects of dexmedetomidine and clonidine on long-term cognitive trajectories, motor activity patterns and biomarkers of neuronal injury, and whether these effects are associated with frailty status.METHODS AND ANALYSIS: This five-centre, double-blind randomised controlled trial will include 900 cardiac surgery patients aged 70+ years. Participants will be randomised 1:1:1 to dexmedetomidine or clonidine or placebo. The study drug will be given as a continuous intravenous infusion from the start of cardiopulmonary bypass, at a rate of 0.4 µg/kg/hour. The infusion rate will be decreased to 0.2 µg/kg/hour postoperatively and be continued until discharge from the ICU or 24 hours postoperatively, whichever happens first.Primary end point is the 7-day cumulative incidence of postoperative delirium (Diagnostic and Statistical Manual of Mental Disorders, fifth edition). Secondary end points include the composite end point of coma, delirium or death, in addition to delirium severity and motor activity patterns, levels of circulating biomarkers of neuronal injury, cognitive function and frailty status 1 and 6 months after surgery.ETHICS AND DISSEMINATION: This trial is approved by the Regional Committee for Ethics in Medical Research in Norway (South-East Norway) and by the Norwegian Medicines Agency. Dissemination plans include publication in peer-reviewed medical journals and presentation at scientific meetings.TRIAL REGISTRATION NUMBER: NCT05029050.
KW - adult anaesthesia
KW - cardiac surgery
KW - delirium & cognitive disorders
KW - geriatric medicine
UR - http://www.scopus.com/inward/record.url?scp=85132290294&partnerID=8YFLogxK
U2 - 10.1136/bmjopen-2021-057460
DO - 10.1136/bmjopen-2021-057460
M3 - Article
C2 - 35725264
SN - 2044-6055
VL - 12
JO - BMJ Open
JF - BMJ Open
IS - 6
M1 - e057460
ER -