Allelic association analysis of the 5-HT(2C) receptor gene in bipolar affective disorder

Blanca Gutiérrez; Lourdes Fañanás; María J. Arranz; Vicenç Vallès; Roser Guillamat; Jim Van Os; David Collier

doi:10.1016/0304-3940(96)12746-4

Allelic association analysis of the 5-HT(2C) receptor gene in bipolar affective disorder

Blanca Gutiérrez, Lourdes Fañanás^*, María J. Arranz, Vicenç Vallès, Roser Guillamat, Jim Van Os, David Collier

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

We have examined a structural variant of the 5-HT(2C) receptor (Cys23Ser) for allelic association with bipolar affective disorder in 88 cases and 113 controls. Overall, there was no significant difference in allele frequencies between the two groups, indicating that the 5-HT(2C) gene is not a major risk factor for bipolar affective disorder. However, when the subjects were analysed according to sex, there was a small excess of the serine ser23 allele in female cases (P = 0.04) and this effect was also seen if the ser23 allele was considered recessive (P = 0.03). A small increase in significance was found if only female cases with a known family history were included (P = 0.01). These results suggest that the ser23 allele may increase susceptibility to bipolar affective disorder in women.

Original language	English
Pages (from-to)	65-67
Number of pages	3
Journal	Neuroscience Letters
Volume	212
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(96)12746-4
Publication status	Published - 5 Jul 1996
Externally published	Yes

Keywords

5-HT(2C) receptor
Association study
Gender differences
Manic depression

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10.1016/0304-3940(96)12746-4

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title = "Allelic association analysis of the 5-HT(2C) receptor gene in bipolar affective disorder",

abstract = "We have examined a structural variant of the 5-HT(2C) receptor (Cys23Ser) for allelic association with bipolar affective disorder in 88 cases and 113 controls. Overall, there was no significant difference in allele frequencies between the two groups, indicating that the 5-HT(2C) gene is not a major risk factor for bipolar affective disorder. However, when the subjects were analysed according to sex, there was a small excess of the serine ser23 allele in female cases (P = 0.04) and this effect was also seen if the ser23 allele was considered recessive (P = 0.03). A small increase in significance was found if only female cases with a known family history were included (P = 0.01). These results suggest that the ser23 allele may increase susceptibility to bipolar affective disorder in women.",

keywords = "5-HT(2C) receptor, Association study, Gender differences, Manic depression",

author = "Blanca Guti{\'e}rrez and Lourdes Fa{\~n}an{\'a}s and Arranz, {Mar{\'i}a J.} and Vicen{\c c} Vall{\`e}s and Roser Guillamat and {Van Os}, Jim and David Collier",

note = "Funding Information: This work was supportedb y a grant from the British Council and the SpanishM inistryof Educationa nd Science (project 100B). Blanca Guti6rrez was awarded a PhD grant (ISP/5-95)b y the 'InstituUt niversitardi e Salut Ptiblicad e Catalunya'T.h e contributioonf Carlos Torrico (Institutd e RecercaO ncolbgicaIR O, BarcelonaS, pain)is gratefullya cknowledgedW. e are gratefult o the HGMP ResourceC entre,Hinxton Hall, CambridgeshireU,K for the provisiono f oligonucleotidper imersf or this research.",

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AU - Gutiérrez, Blanca

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AU - Arranz, María J.

AU - Vallès, Vicenç

AU - Guillamat, Roser

AU - Van Os, Jim

AU - Collier, David

N1 - Funding Information: This work was supportedb y a grant from the British Council and the SpanishM inistryof Educationa nd Science (project 100B). Blanca Guti6rrez was awarded a PhD grant (ISP/5-95)b y the 'InstituUt niversitardi e Salut Ptiblicad e Catalunya'T.h e contributioonf Carlos Torrico (Institutd e RecercaO ncolbgicaIR O, BarcelonaS, pain)is gratefullya cknowledgedW. e are gratefult o the HGMP ResourceC entre,Hinxton Hall, CambridgeshireU,K for the provisiono f oligonucleotidper imersf or this research.

PY - 1996/7/5

Y1 - 1996/7/5

N2 - We have examined a structural variant of the 5-HT(2C) receptor (Cys23Ser) for allelic association with bipolar affective disorder in 88 cases and 113 controls. Overall, there was no significant difference in allele frequencies between the two groups, indicating that the 5-HT(2C) gene is not a major risk factor for bipolar affective disorder. However, when the subjects were analysed according to sex, there was a small excess of the serine ser23 allele in female cases (P = 0.04) and this effect was also seen if the ser23 allele was considered recessive (P = 0.03). A small increase in significance was found if only female cases with a known family history were included (P = 0.01). These results suggest that the ser23 allele may increase susceptibility to bipolar affective disorder in women.

AB - We have examined a structural variant of the 5-HT(2C) receptor (Cys23Ser) for allelic association with bipolar affective disorder in 88 cases and 113 controls. Overall, there was no significant difference in allele frequencies between the two groups, indicating that the 5-HT(2C) gene is not a major risk factor for bipolar affective disorder. However, when the subjects were analysed according to sex, there was a small excess of the serine ser23 allele in female cases (P = 0.04) and this effect was also seen if the ser23 allele was considered recessive (P = 0.03). A small increase in significance was found if only female cases with a known family history were included (P = 0.01). These results suggest that the ser23 allele may increase susceptibility to bipolar affective disorder in women.

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Allelic association analysis of the 5-HT(2C) receptor gene in bipolar affective disorder

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Keywords

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