Alcohol intake and breast cancer in the European prospective investigation into cancer and nutrition

Isabelle Romieu; Chiara Scoccianti; Véronique Chajès; Jordi De Batlle; Carine Biessy; Laure Dossus; Laura Baglietto; Françoise Clavel-Chapelon; Kim Overvad; Anja Olsen; Anne Tjønneland; Rudolf Kaaks; Annekatrin Lukanova; Heiner Boeing; Antonia Trichopoulou; Pagona Lagiou; Dimitrios Trichopoulos; Domenico Palli; Sabina Sieri; Rosario Tumino; Paolo Vineis; Salvatore Panico; H. Bas Bueno-De-Mesquita; Carla H. Van Gils; Petra H. Peeters; Eiliv Lund; Guri Skeie; Elisabete Weiderpass; José Ramõn Quirõs García; María Dolores Chirlaque; Eva Ardanaz; María José Sánchez; Eric J. Duell; Pilar Amiano; Signe Borgquist; Elisabet Wirfält; Göran Hallmans; Ingegerd Johansson; Lena Maria Nilsson; Kay Tee Khaw; Nick Wareham; Timothy J. Key; Ruth C. Travis; Neil Murphy; Petra A. Wark; Pietro Ferrari; Elio Riboli

doi:10.1002/ijc.29469

Alcohol intake and breast cancer in the European prospective investigation into cancer and nutrition

Isabelle Romieu^*, Chiara Scoccianti, Véronique Chajès, Jordi De Batlle, Carine Biessy, Laure Dossus, Laura Baglietto, Françoise Clavel-Chapelon, Kim Overvad, Anja Olsen, Anne Tjønneland, Rudolf Kaaks, Annekatrin Lukanova, Heiner Boeing, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Domenico Palli, Sabina Sieri, Rosario TuminoPaolo Vineis, Salvatore Panico, H. Bas Bueno-De-Mesquita, Carla H. Van Gils, Petra H. Peeters, Eiliv Lund, Guri Skeie, Elisabete Weiderpass, José Ramõn Quirõs García, María Dolores Chirlaque, Eva Ardanaz, María José Sánchez, Eric J. Duell, Pilar Amiano, Signe Borgquist, Elisabet Wirfält, Göran Hallmans, Ingegerd Johansson, Lena Maria Nilsson, Kay Tee Khaw, Nick Wareham, Timothy J. Key, Ruth C. Travis, Neil Murphy, Petra A. Wark, Pietro Ferrari, Elio Riboli

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Alcohol intake has been associated to breast cancer in pre and postmenopausal women; however results are inconclusive regarding tumor hormonal receptor status, and potential modifying factors like age at start drinking. Therefore, we investigated the relation between alcohol intake and the risk of breast cancer using prospective observational data from the European Prospective Investigation into Cancer and Nutrition (EPIC). Up to 334,850 women, aged 35-70 years at baseline, were recruited in ten European countries and followed up an average of 11 years. Alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. The study outcomes were the Hazard ratios (HR) of developing breast cancer according to hormonal receptor status. During 3,670,439 person-years, 11,576 incident breast cancer cases were diagnosed. Alcohol intake was significantly related to breast cancer risk, for each 10 g/day increase in alcohol intake the HR increased by 4.2% (95% CI: 2.7-5.8%). Taking 0 to 5 g/day as reference, alcohol intake of >5 to 15 g/day was related to a 5.9% increase in breast cancer risk (95% CI: 1-11%). Significant increasing trends were observed between alcohol intake and ER+/PR+, ER-/PR-, HER2- and ER-/PR-HER2- tumors. Breast cancer risk was stronger among women who started drinking prior to first full-time pregnancy. Overall, our results confirm the association between alcohol intake and both hormone receptor positive and hormone receptor negative breast tumors, suggesting that timing of exposure to alcohol drinking may affect the risk. Therefore, women should be advised to control their alcohol consumption. What's new? Although it is now established that alcohol consumption increases breast cancer risk, many questions remain. Using a prospective study design with 11,576 incident breast cancer cases across 10 European countries, the authors confirmed the increased risk of alcohol on breast cancer development. They further show that women who started drinking before their first full-term pregnancy have a higher risk than women who started afterwards. These effects were observed in hormone-receptor positive and -negative tumors pointing to non-hormonal pathways that need to be further investigated.

Original language	English
Pages (from-to)	1921-1930
Number of pages	10
Journal	International Journal of Cancer
Volume	137
Issue number	8
DOIs	https://doi.org/10.1002/ijc.29469
Publication status	Published - 1 Jan 2015

Keywords

alcohol consumption
breast cancer
prospective study

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10.1002/ijc.29469

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Romieu, I., Scoccianti, C., Chajès, V., De Batlle, J., Biessy, C., Dossus, L., Baglietto, L., Clavel-Chapelon, F., Overvad, K., Olsen, A., Tjønneland, A., Kaaks, R., Lukanova, A., Boeing, H., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Sieri, S., ... Riboli, E. (2015). Alcohol intake and breast cancer in the European prospective investigation into cancer and nutrition. International Journal of Cancer, 137(8), 1921-1930. https://doi.org/10.1002/ijc.29469

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title = "Alcohol intake and breast cancer in the European prospective investigation into cancer and nutrition",

abstract = "Alcohol intake has been associated to breast cancer in pre and postmenopausal women; however results are inconclusive regarding tumor hormonal receptor status, and potential modifying factors like age at start drinking. Therefore, we investigated the relation between alcohol intake and the risk of breast cancer using prospective observational data from the European Prospective Investigation into Cancer and Nutrition (EPIC). Up to 334,850 women, aged 35-70 years at baseline, were recruited in ten European countries and followed up an average of 11 years. Alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. The study outcomes were the Hazard ratios (HR) of developing breast cancer according to hormonal receptor status. During 3,670,439 person-years, 11,576 incident breast cancer cases were diagnosed. Alcohol intake was significantly related to breast cancer risk, for each 10 g/day increase in alcohol intake the HR increased by 4.2% (95% CI: 2.7-5.8%). Taking 0 to 5 g/day as reference, alcohol intake of >5 to 15 g/day was related to a 5.9% increase in breast cancer risk (95% CI: 1-11%). Significant increasing trends were observed between alcohol intake and ER+/PR+, ER-/PR-, HER2- and ER-/PR-HER2- tumors. Breast cancer risk was stronger among women who started drinking prior to first full-time pregnancy. Overall, our results confirm the association between alcohol intake and both hormone receptor positive and hormone receptor negative breast tumors, suggesting that timing of exposure to alcohol drinking may affect the risk. Therefore, women should be advised to control their alcohol consumption. What's new? Although it is now established that alcohol consumption increases breast cancer risk, many questions remain. Using a prospective study design with 11,576 incident breast cancer cases across 10 European countries, the authors confirmed the increased risk of alcohol on breast cancer development. They further show that women who started drinking before their first full-term pregnancy have a higher risk than women who started afterwards. These effects were observed in hormone-receptor positive and -negative tumors pointing to non-hormonal pathways that need to be further investigated.",

keywords = "alcohol consumption, breast cancer, prospective study",

author = "Isabelle Romieu and Chiara Scoccianti and V{\'e}ronique Chaj{\`e}s and {De Batlle}, Jordi and Carine Biessy and Laure Dossus and Laura Baglietto and Fran{\c c}oise Clavel-Chapelon and Kim Overvad and Anja Olsen and Anne Tj{\o}nneland and Rudolf Kaaks and Annekatrin Lukanova and Heiner Boeing and Antonia Trichopoulou and Pagona Lagiou and Dimitrios Trichopoulos and Domenico Palli and Sabina Sieri and Rosario Tumino and Paolo Vineis and Salvatore Panico and Bueno-De-Mesquita, {H. Bas} and {Van Gils}, {Carla H.} and Peeters, {Petra H.} and Eiliv Lund and Guri Skeie and Elisabete Weiderpass and Garc{\'i}a, {Jos{\'e} Ram{\~o}n Quir{\~o}s} and Chirlaque, {Mar{\'i}a Dolores} and Eva Ardanaz and S{\'a}nchez, {Mar{\'i}a Jos{\'e}} and Duell, {Eric J.} and Pilar Amiano and Signe Borgquist and Elisabet Wirf{\"a}lt and G{\"o}ran Hallmans and Ingegerd Johansson and Nilsson, {Lena Maria} and Khaw, {Kay Tee} and Nick Wareham and Key, {Timothy J.} and Travis, {Ruth C.} and Neil Murphy and Wark, {Petra A.} and Pietro Ferrari and Elio Riboli",

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doi = "10.1002/ijc.29469",

language = "English",

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journal = "International Journal of Cancer",

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Romieu, I, Scoccianti, C, Chajès, V, De Batlle, J, Biessy, C, Dossus, L, Baglietto, L, Clavel-Chapelon, F, Overvad, K, Olsen, A, Tjønneland, A, Kaaks, R, Lukanova, A, Boeing, H, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Palli, D, Sieri, S, Tumino, R, Vineis, P, Panico, S, Bueno-De-Mesquita, HB, Van Gils, CH, Peeters, PH, Lund, E, Skeie, G, Weiderpass, E, García, JRQ, Chirlaque, MD, Ardanaz, E, Sánchez, MJ, Duell, EJ, Amiano, P, Borgquist, S, Wirfält, E, Hallmans, G, Johansson, I, Nilsson, LM, Khaw, KT, Wareham, N, Key, TJ, Travis, RC, Murphy, N, Wark, PA, Ferrari, P & Riboli, E 2015, 'Alcohol intake and breast cancer in the European prospective investigation into cancer and nutrition', International Journal of Cancer, vol. 137, no. 8, pp. 1921-1930. https://doi.org/10.1002/ijc.29469

TY - JOUR

T1 - Alcohol intake and breast cancer in the European prospective investigation into cancer and nutrition

AU - Romieu, Isabelle

AU - Scoccianti, Chiara

AU - Chajès, Véronique

AU - De Batlle, Jordi

AU - Biessy, Carine

AU - Dossus, Laure

AU - Baglietto, Laura

AU - Clavel-Chapelon, Françoise

AU - Overvad, Kim

AU - Olsen, Anja

AU - Tjønneland, Anne

AU - Kaaks, Rudolf

AU - Lukanova, Annekatrin

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - Lagiou, Pagona

AU - Trichopoulos, Dimitrios

AU - Palli, Domenico

AU - Sieri, Sabina

AU - Tumino, Rosario

AU - Vineis, Paolo

AU - Panico, Salvatore

AU - Bueno-De-Mesquita, H. Bas

AU - Van Gils, Carla H.

AU - Peeters, Petra H.

AU - Lund, Eiliv

AU - Skeie, Guri

AU - Weiderpass, Elisabete

AU - García, José Ramõn Quirõs

AU - Chirlaque, María Dolores

AU - Ardanaz, Eva

AU - Sánchez, María José

AU - Duell, Eric J.

AU - Amiano, Pilar

AU - Borgquist, Signe

AU - Wirfält, Elisabet

AU - Hallmans, Göran

AU - Johansson, Ingegerd

AU - Nilsson, Lena Maria

AU - Khaw, Kay Tee

AU - Wareham, Nick

AU - Key, Timothy J.

AU - Travis, Ruth C.

AU - Murphy, Neil

AU - Wark, Petra A.

AU - Ferrari, Pietro

AU - Riboli, Elio

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Alcohol intake has been associated to breast cancer in pre and postmenopausal women; however results are inconclusive regarding tumor hormonal receptor status, and potential modifying factors like age at start drinking. Therefore, we investigated the relation between alcohol intake and the risk of breast cancer using prospective observational data from the European Prospective Investigation into Cancer and Nutrition (EPIC). Up to 334,850 women, aged 35-70 years at baseline, were recruited in ten European countries and followed up an average of 11 years. Alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. The study outcomes were the Hazard ratios (HR) of developing breast cancer according to hormonal receptor status. During 3,670,439 person-years, 11,576 incident breast cancer cases were diagnosed. Alcohol intake was significantly related to breast cancer risk, for each 10 g/day increase in alcohol intake the HR increased by 4.2% (95% CI: 2.7-5.8%). Taking 0 to 5 g/day as reference, alcohol intake of >5 to 15 g/day was related to a 5.9% increase in breast cancer risk (95% CI: 1-11%). Significant increasing trends were observed between alcohol intake and ER+/PR+, ER-/PR-, HER2- and ER-/PR-HER2- tumors. Breast cancer risk was stronger among women who started drinking prior to first full-time pregnancy. Overall, our results confirm the association between alcohol intake and both hormone receptor positive and hormone receptor negative breast tumors, suggesting that timing of exposure to alcohol drinking may affect the risk. Therefore, women should be advised to control their alcohol consumption. What's new? Although it is now established that alcohol consumption increases breast cancer risk, many questions remain. Using a prospective study design with 11,576 incident breast cancer cases across 10 European countries, the authors confirmed the increased risk of alcohol on breast cancer development. They further show that women who started drinking before their first full-term pregnancy have a higher risk than women who started afterwards. These effects were observed in hormone-receptor positive and -negative tumors pointing to non-hormonal pathways that need to be further investigated.

AB - Alcohol intake has been associated to breast cancer in pre and postmenopausal women; however results are inconclusive regarding tumor hormonal receptor status, and potential modifying factors like age at start drinking. Therefore, we investigated the relation between alcohol intake and the risk of breast cancer using prospective observational data from the European Prospective Investigation into Cancer and Nutrition (EPIC). Up to 334,850 women, aged 35-70 years at baseline, were recruited in ten European countries and followed up an average of 11 years. Alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. The study outcomes were the Hazard ratios (HR) of developing breast cancer according to hormonal receptor status. During 3,670,439 person-years, 11,576 incident breast cancer cases were diagnosed. Alcohol intake was significantly related to breast cancer risk, for each 10 g/day increase in alcohol intake the HR increased by 4.2% (95% CI: 2.7-5.8%). Taking 0 to 5 g/day as reference, alcohol intake of >5 to 15 g/day was related to a 5.9% increase in breast cancer risk (95% CI: 1-11%). Significant increasing trends were observed between alcohol intake and ER+/PR+, ER-/PR-, HER2- and ER-/PR-HER2- tumors. Breast cancer risk was stronger among women who started drinking prior to first full-time pregnancy. Overall, our results confirm the association between alcohol intake and both hormone receptor positive and hormone receptor negative breast tumors, suggesting that timing of exposure to alcohol drinking may affect the risk. Therefore, women should be advised to control their alcohol consumption. What's new? Although it is now established that alcohol consumption increases breast cancer risk, many questions remain. Using a prospective study design with 11,576 incident breast cancer cases across 10 European countries, the authors confirmed the increased risk of alcohol on breast cancer development. They further show that women who started drinking before their first full-term pregnancy have a higher risk than women who started afterwards. These effects were observed in hormone-receptor positive and -negative tumors pointing to non-hormonal pathways that need to be further investigated.

KW - alcohol consumption

KW - breast cancer

KW - prospective study

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U2 - 10.1002/ijc.29469

DO - 10.1002/ijc.29469

M3 - Article

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AN - SCOPUS:84938924341

SN - 0020-7136

VL - 137

SP - 1921

EP - 1930

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 8

ER -

Alcohol intake and breast cancer in the European prospective investigation into cancer and nutrition

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