Alcohol facilitates CD1d loading, subsequent activation of NKT cells, and reduces the incidence of diabetes in NOD mice.

K. Buschard; A.K. Hansen; K. Jensen; D.J. Lindenbergh-Kortleve; L.F. de Ruiter; T. Krohn; M.R. Hufeldt; F.K. Vogensen; B. Aasted; T. Osterbye; B.O. Roep; C. de Haar; E.E.S. Nieuwenhuis

doi:10.1371/journal.pone.0017931

Alcohol facilitates CD1d loading, subsequent activation of NKT cells, and reduces the incidence of diabetes in NOD mice.

K. Buschard
, A.K. Hansen
, K. Jensen
, D.J. Lindenbergh-Kortleve
, L.F. de Ruiter
, T. Krohn
, M.R. Hufeldt
, F.K. Vogensen
, B. Aasted
, T. Osterbye
, B.O. Roep
, C. de Haar
, E.E.S. Nieuwenhuis

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Ethanol ('alcohol') is a partly hydrophobic detergent that may affect the accessibility of glycolipids thereby influencing immunological effects of these molecules. METHODS: The study included cellular in vitro tests using α-galactosylceramide (αGalCer), and in vivo NOD mice experiments detecting diabetes incidence and performing behavioural and bacterial analyses. RESULTS: Alcohol in concentrations from 0.6% to 2.5% increased IL-2 production from NKT cells stimulated with αGalCer by 60% (p

Original language	English
Article number	e17931
Journal	PLoS ONE [E]
Volume	6
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0017931
Publication status	Published - 2011

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10.1371/journal.pone.0017931

http://www.ncbi.nlm.nih.gov/pubmed/21483778

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Buschard, K., Hansen, A. K., Jensen, K., Lindenbergh-Kortleve, D. J., de Ruiter, L. F., Krohn, T., Hufeldt, M. R., Vogensen, F. K., Aasted, B., Osterbye, T., Roep, B. O., de Haar, C., & Nieuwenhuis, E. E. S. (2011). Alcohol facilitates CD1d loading, subsequent activation of NKT cells, and reduces the incidence of diabetes in NOD mice. PLoS ONE [E], 6(4), Article e17931. https://doi.org/10.1371/journal.pone.0017931

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title = "Alcohol facilitates CD1d loading, subsequent activation of NKT cells, and reduces the incidence of diabetes in NOD mice.",

abstract = "BACKGROUND: Ethanol ('alcohol') is a partly hydrophobic detergent that may affect the accessibility of glycolipids thereby influencing immunological effects of these molecules. METHODS: The study included cellular in vitro tests using α-galactosylceramide (αGalCer), and in vivo NOD mice experiments detecting diabetes incidence and performing behavioural and bacterial analyses. RESULTS: Alcohol in concentrations from 0.6\% to 2.5\% increased IL-2 production from NKT cells stimulated with αGalCer by 60\% (p",

author = "K. Buschard and A.K. Hansen and K. Jensen and D.J. Lindenbergh-Kortleve and \{de Ruiter\}, L.F. and T. Krohn and M.R. Hufeldt and F.K. Vogensen and B. Aasted and T. Osterbye and B.O. Roep and \{de Haar\}, C. and E.E.S. Nieuwenhuis",

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Buschard, K, Hansen, AK, Jensen, K, Lindenbergh-Kortleve, DJ, de Ruiter, LF, Krohn, T, Hufeldt, MR, Vogensen, FK, Aasted, B, Osterbye, T, Roep, BO, de Haar, C & Nieuwenhuis, EES 2011, 'Alcohol facilitates CD1d loading, subsequent activation of NKT cells, and reduces the incidence of diabetes in NOD mice.', PLoS ONE [E], vol. 6, no. 4, e17931. https://doi.org/10.1371/journal.pone.0017931

TY - JOUR

T1 - Alcohol facilitates CD1d loading, subsequent activation of NKT cells, and reduces the incidence of diabetes in NOD mice.

AU - Buschard, K.

AU - Hansen, A.K.

AU - Jensen, K.

AU - Lindenbergh-Kortleve, D.J.

AU - de Ruiter, L.F.

AU - Krohn, T.

AU - Hufeldt, M.R.

AU - Vogensen, F.K.

AU - Aasted, B.

AU - Osterbye, T.

AU - Roep, B.O.

AU - de Haar, C.

AU - Nieuwenhuis, E.E.S.

PY - 2011

Y1 - 2011

N2 - BACKGROUND: Ethanol ('alcohol') is a partly hydrophobic detergent that may affect the accessibility of glycolipids thereby influencing immunological effects of these molecules. METHODS: The study included cellular in vitro tests using α-galactosylceramide (αGalCer), and in vivo NOD mice experiments detecting diabetes incidence and performing behavioural and bacterial analyses. RESULTS: Alcohol in concentrations from 0.6% to 2.5% increased IL-2 production from NKT cells stimulated with αGalCer by 60% (p

AB - BACKGROUND: Ethanol ('alcohol') is a partly hydrophobic detergent that may affect the accessibility of glycolipids thereby influencing immunological effects of these molecules. METHODS: The study included cellular in vitro tests using α-galactosylceramide (αGalCer), and in vivo NOD mice experiments detecting diabetes incidence and performing behavioural and bacterial analyses. RESULTS: Alcohol in concentrations from 0.6% to 2.5% increased IL-2 production from NKT cells stimulated with αGalCer by 60% (p

U2 - 10.1371/journal.pone.0017931

DO - 10.1371/journal.pone.0017931

M3 - Article

C2 - 21483778

SN - 1932-6203

VL - 6

JO - PLoS ONE [E]

JF - PLoS ONE [E]

IS - 4

M1 - e17931

ER -

Alcohol facilitates CD1d loading, subsequent activation of NKT cells, and reduces the incidence of diabetes in NOD mice.

Abstract

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