Airway wall thickness associated with forced expiratory volume in 1 second decline and development of airflow limitation

F.A.A. Mohamed Hoesein; Pim A. de Jong; Jan-Willem J. Lammers; Willem P. T. M. Mali; Michael Schmidt; Harry J. de Koning; Carlijn van der Aalst; Matthijs Oudkerk; Rozemarijn Vliegenthart; Harry J. M. Groen; Bram van Ginneken; Eva M. van Rikxoort; Pieter Zanen

doi:10.1183/09031936.00020714

Airway wall thickness associated with forced expiratory volume in 1 second decline and development of airflow limitation

F.A.A. Mohamed Hoesein, Pim A. de Jong, Jan-Willem J. Lammers, Willem P. T. M. Mali, Michael Schmidt, Harry J. de Koning, Carlijn van der Aalst, Matthijs Oudkerk, Rozemarijn Vliegenthart, Harry J. M. Groen, Bram van Ginneken, Eva M. van Rikxoort, Pieter Zanen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Airway wall thickness and emphysema contribute to airflow limitation.

We examined their association with lung function decline and development of airflow limitation in 2021 male smokers with and without airflow limitation. Airway wall thickness and emphysema were quantified on chest computed tomography and expressed as the square root of wall area of a 10-mm lumen perimeter (Pi10) and the 15th percentile method (Perc15), respectively. Baseline and follow-up (median (interquartile range) 3 (2.9-3.1) years) spirometry was available.

Pi10 and Perc15 correlated with baseline forced expiratory volume in 1 s (FEV1) (r=-0.49 and 0.11, respectively (p<0.001)). Multiple linear regression showed that Pi10 and Perc15 at baseline were associated with a lower FEV1 after follow-up (p<0.05). For each SD increase in Pi10 and decrease in Perc15 the FEV1 decreased by 20mL and 30.2mL, respectively. The odds ratio for developing airflow limitation after 3 years was 2.45 for a 1-mm higher Pi10 and 1.46 for a 10-HU lower Perc15 (p<0.001).

A greater degree of airway wall thickness and emphysema was associated with a higher FEV1 decline and development of airflow limitation after 3 years of follow-up.

Original language	English
Pages (from-to)	644-651
Number of pages	8
Journal	European Respiratory Journal
Volume	45
Issue number	3
DOIs	https://doi.org/10.1183/09031936.00020714
Publication status	Published - Mar 2015

Keywords

OBSTRUCTIVE PULMONARY-DISEASE
LUNG-FUNCTION
COMPUTED-TOMOGRAPHY
HEAVY SMOKERS
EMPHYSEMA
DIMENSIONS
SCANS
COPD
AGE

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Mohamed Hoesein, F. A. A., de Jong, P. A., Lammers, J.-W. J., Mali, W. P. T. M., Schmidt, M., de Koning, H. J., van der Aalst, C., Oudkerk, M., Vliegenthart, R., Groen, H. J. M., van Ginneken, B., van Rikxoort, E. M., & Zanen, P. (2015). Airway wall thickness associated with forced expiratory volume in 1 second decline and development of airflow limitation. European Respiratory Journal, 45(3), 644-651. https://doi.org/10.1183/09031936.00020714

@article{5a57fa0cad244214aeae7531b15118b7,

title = "Airway wall thickness associated with forced expiratory volume in 1 second decline and development of airflow limitation",

abstract = "Airway wall thickness and emphysema contribute to airflow limitation.We examined their association with lung function decline and development of airflow limitation in 2021 male smokers with and without airflow limitation. Airway wall thickness and emphysema were quantified on chest computed tomography and expressed as the square root of wall area of a 10-mm lumen perimeter (Pi10) and the 15th percentile method (Perc15), respectively. Baseline and follow-up (median (interquartile range) 3 (2.9-3.1) years) spirometry was available.Pi10 and Perc15 correlated with baseline forced expiratory volume in 1 s (FEV1) (r=-0.49 and 0.11, respectively (p<0.001)). Multiple linear regression showed that Pi10 and Perc15 at baseline were associated with a lower FEV1 after follow-up (p<0.05). For each SD increase in Pi10 and decrease in Perc15 the FEV1 decreased by 20mL and 30.2mL, respectively. The odds ratio for developing airflow limitation after 3 years was 2.45 for a 1-mm higher Pi10 and 1.46 for a 10-HU lower Perc15 (p<0.001).A greater degree of airway wall thickness and emphysema was associated with a higher FEV1 decline and development of airflow limitation after 3 years of follow-up.",

keywords = "OBSTRUCTIVE PULMONARY-DISEASE, LUNG-FUNCTION, COMPUTED-TOMOGRAPHY, HEAVY SMOKERS, EMPHYSEMA, DIMENSIONS, SCANS, COPD, AGE",

author = "{Mohamed Hoesein}, F.A.A. and {de Jong}, {Pim A.} and Lammers, {Jan-Willem J.} and Mali, {Willem P. T. M.} and Michael Schmidt and {de Koning}, {Harry J.} and {van der Aalst}, Carlijn and Matthijs Oudkerk and Rozemarijn Vliegenthart and Groen, {Harry J. M.} and {van Ginneken}, Bram and {van Rikxoort}, {Eva M.} and Pieter Zanen",

year = "2015",

month = mar,

doi = "10.1183/09031936.00020714",

language = "English",

volume = "45",

pages = "644--651",

journal = "European Respiratory Journal",

issn = "0903-1936",

publisher = "European Respiratory Society",

number = "3",

}

Mohamed Hoesein, FAA, de Jong, PA, Lammers, J-WJ, Mali, WPTM, Schmidt, M, de Koning, HJ, van der Aalst, C, Oudkerk, M, Vliegenthart, R, Groen, HJM, van Ginneken, B, van Rikxoort, EM & Zanen, P 2015, 'Airway wall thickness associated with forced expiratory volume in 1 second decline and development of airflow limitation', European Respiratory Journal, vol. 45, no. 3, pp. 644-651. https://doi.org/10.1183/09031936.00020714

TY - JOUR

T1 - Airway wall thickness associated with forced expiratory volume in 1 second decline and development of airflow limitation

AU - Mohamed Hoesein, F.A.A.

AU - de Jong, Pim A.

AU - Lammers, Jan-Willem J.

AU - Mali, Willem P. T. M.

AU - Schmidt, Michael

AU - de Koning, Harry J.

AU - van der Aalst, Carlijn

AU - Oudkerk, Matthijs

AU - Vliegenthart, Rozemarijn

AU - Groen, Harry J. M.

AU - van Ginneken, Bram

AU - van Rikxoort, Eva M.

AU - Zanen, Pieter

PY - 2015/3

Y1 - 2015/3

N2 - Airway wall thickness and emphysema contribute to airflow limitation.We examined their association with lung function decline and development of airflow limitation in 2021 male smokers with and without airflow limitation. Airway wall thickness and emphysema were quantified on chest computed tomography and expressed as the square root of wall area of a 10-mm lumen perimeter (Pi10) and the 15th percentile method (Perc15), respectively. Baseline and follow-up (median (interquartile range) 3 (2.9-3.1) years) spirometry was available.Pi10 and Perc15 correlated with baseline forced expiratory volume in 1 s (FEV1) (r=-0.49 and 0.11, respectively (p<0.001)). Multiple linear regression showed that Pi10 and Perc15 at baseline were associated with a lower FEV1 after follow-up (p<0.05). For each SD increase in Pi10 and decrease in Perc15 the FEV1 decreased by 20mL and 30.2mL, respectively. The odds ratio for developing airflow limitation after 3 years was 2.45 for a 1-mm higher Pi10 and 1.46 for a 10-HU lower Perc15 (p<0.001).A greater degree of airway wall thickness and emphysema was associated with a higher FEV1 decline and development of airflow limitation after 3 years of follow-up.

AB - Airway wall thickness and emphysema contribute to airflow limitation.We examined their association with lung function decline and development of airflow limitation in 2021 male smokers with and without airflow limitation. Airway wall thickness and emphysema were quantified on chest computed tomography and expressed as the square root of wall area of a 10-mm lumen perimeter (Pi10) and the 15th percentile method (Perc15), respectively. Baseline and follow-up (median (interquartile range) 3 (2.9-3.1) years) spirometry was available.Pi10 and Perc15 correlated with baseline forced expiratory volume in 1 s (FEV1) (r=-0.49 and 0.11, respectively (p<0.001)). Multiple linear regression showed that Pi10 and Perc15 at baseline were associated with a lower FEV1 after follow-up (p<0.05). For each SD increase in Pi10 and decrease in Perc15 the FEV1 decreased by 20mL and 30.2mL, respectively. The odds ratio for developing airflow limitation after 3 years was 2.45 for a 1-mm higher Pi10 and 1.46 for a 10-HU lower Perc15 (p<0.001).A greater degree of airway wall thickness and emphysema was associated with a higher FEV1 decline and development of airflow limitation after 3 years of follow-up.

KW - OBSTRUCTIVE PULMONARY-DISEASE

KW - LUNG-FUNCTION

KW - COMPUTED-TOMOGRAPHY

KW - HEAVY SMOKERS

KW - EMPHYSEMA

KW - DIMENSIONS

KW - SCANS

KW - COPD

KW - AGE

U2 - 10.1183/09031936.00020714

DO - 10.1183/09031936.00020714

M3 - Article

C2 - 25614166

SN - 0903-1936

VL - 45

SP - 644

EP - 651

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - 3

ER -

Airway wall thickness associated with forced expiratory volume in 1 second decline and development of airflow limitation

Abstract

Keywords

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