Air pollution and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts for Air Pollution Effects (ESCAPE)

Gabriele Nagel; Massimo Stafoggia; Marie Pedersen; Zorana J. Andersen; Claudia Galassi; Jule Munkenast; Andrea Jaensch; Johan Sommar; Bertil Forsberg; David Olsson; Bente Oftedal; Norun H. Krog; Geir Aamodt; Andrei Pyko; Göran Pershagen; Michal Korek; Ulf De Faire; Nancy L. Pedersen; Claes Göran Östenson; Laura Fratiglioni; Mette Sørensen; Anne Tjønneland; Petra H. Peeters; Bas Bueno-de-Mesquita; Roel Vermeulen; Marloes Eeftens; Michelle Plusquin; Timothy J. Key; Hans Concin; Alois Lang; Meng Wang; Ming Yi Tsai; Sara Grioni; Alessandro Marcon; Vittorio Krogh; Fulvio Ricceri; Carlotta Sacerdote; Andrea Ranzi; Giulia Cesaroni; Francesco Forastiere; Ibon Tamayo-Uria; Pilar Amiano; Miren Dorronsoro; Kees de Hoogh; Rob Beelen; Paolo Vineis; Bert Brunekreef; Gerard Hoek; Ole Raaschou-Nielsen; Gudrun Weinmayr

doi:10.1002/ijc.31564

Air pollution and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts for Air Pollution Effects (ESCAPE)

Gabriele Nagel^*, Massimo Stafoggia, Marie Pedersen, Zorana J. Andersen, Claudia Galassi, Jule Munkenast, Andrea Jaensch, Johan Sommar, Bertil Forsberg, David Olsson, Bente Oftedal, Norun H. Krog, Geir Aamodt, Andrei Pyko, Göran Pershagen, Michal Korek, Ulf De Faire, Nancy L. Pedersen, Claes Göran Östenson, Laura FratiglioniMette Sørensen, Anne Tjønneland, Petra H. Peeters, Bas Bueno-de-Mesquita, Roel Vermeulen, Marloes Eeftens, Michelle Plusquin, Timothy J. Key, Hans Concin, Alois Lang, Meng Wang, Ming Yi Tsai, Sara Grioni, Alessandro Marcon, Vittorio Krogh, Fulvio Ricceri, Carlotta Sacerdote, Andrea Ranzi, Giulia Cesaroni, Francesco Forastiere, Ibon Tamayo-Uria, Pilar Amiano, Miren Dorronsoro, Kees de Hoogh, Rob Beelen, Paolo Vineis, Bert Brunekreef, Gerard Hoek, Ole Raaschou-Nielsen, Gudrun Weinmayr

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Air pollution has been classified as carcinogenic to humans. However, to date little is known about the relevance for cancers of the stomach and upper aerodigestive tract (UADT). We investigated the association of long-term exposure to ambient air pollution with incidence of gastric and UADT cancer in 11 European cohorts. Air pollution exposure was assigned by land-use regression models for particulate matter (PM) below 10 μm (PM₁₀), below 2.5 μm (PM_2.5), between 2.5 and 10 μm (PM_coarse), PM_2.5 absorbance and nitrogen oxides (NO₂ and NO_X) as well as approximated by traffic indicators. Cox regression models with adjustment for potential confounders were used for cohort-specific analyses. Combined estimates were determined with random effects meta-analyses. During average follow-up of 14.1 years of 305,551 individuals, 744 incident cases of gastric cancer and 933 of UADT cancer occurred. The hazard ratio for an increase of 5 μg/m³ of PM_2.5 was 1.38 (95% CI 0.99; 1.92) for gastric and 1.05 (95% CI 0.62; 1.77) for UADT cancers. No associations were found for any of the other exposures considered. Adjustment for additional confounders and restriction to study participants with stable addresses did not influence markedly the effect estimate for PM_2.5 and gastric cancer. Higher estimated risks of gastric cancer associated with PM_2.5 was found in men (HR 1.98 [1.30; 3.01]) as compared to women (HR 0.85 [0.5; 1.45]). This large multicentre cohort study shows an association between long-term exposure to PM_2.5 and gastric cancer, but not UADT cancers, suggesting that air pollution may contribute to gastric cancer risk.

Original language	English
Pages (from-to)	1632-1643
Number of pages	12
Journal	International Journal of Cancer
Volume	143
Issue number	7
Early online date	26 Apr 2018
DOIs	https://doi.org/10.1002/ijc.31564
Publication status	Published - 1 Oct 2018

Keywords

Air pollution
Epidemiology
ESCAPE
Gastric cancer
Upper aerodigestive tract cancer
epidemiology
gastric cancer
air pollution
upper aerodigestive tract cancer

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10.1002/ijc.31564

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Nagel, G., Stafoggia, M., Pedersen, M., Andersen, Z. J., Galassi, C., Munkenast, J., Jaensch, A., Sommar, J., Forsberg, B., Olsson, D., Oftedal, B., Krog, N. H., Aamodt, G., Pyko, A., Pershagen, G., Korek, M., De Faire, U., Pedersen, N. L., Östenson, C. G., ... Weinmayr, G. (2018). Air pollution and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts for Air Pollution Effects (ESCAPE). International Journal of Cancer, 143(7), 1632-1643. https://doi.org/10.1002/ijc.31564

@article{abc2d18b0e9e451c86e058bb5a1512b4,

title = "Air pollution and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts for Air Pollution Effects (ESCAPE)",

abstract = "Air pollution has been classified as carcinogenic to humans. However, to date little is known about the relevance for cancers of the stomach and upper aerodigestive tract (UADT). We investigated the association of long-term exposure to ambient air pollution with incidence of gastric and UADT cancer in 11 European cohorts. Air pollution exposure was assigned by land-use regression models for particulate matter (PM) below 10 μm (PM10), below 2.5 μm (PM2.5), between 2.5 and 10 μm (PMcoarse), PM2.5 absorbance and nitrogen oxides (NO2 and NOX) as well as approximated by traffic indicators. Cox regression models with adjustment for potential confounders were used for cohort-specific analyses. Combined estimates were determined with random effects meta-analyses. During average follow-up of 14.1 years of 305,551 individuals, 744 incident cases of gastric cancer and 933 of UADT cancer occurred. The hazard ratio for an increase of 5 μg/m3 of PM2.5 was 1.38 (95% CI 0.99; 1.92) for gastric and 1.05 (95% CI 0.62; 1.77) for UADT cancers. No associations were found for any of the other exposures considered. Adjustment for additional confounders and restriction to study participants with stable addresses did not influence markedly the effect estimate for PM2.5 and gastric cancer. Higher estimated risks of gastric cancer associated with PM2.5 was found in men (HR 1.98 [1.30; 3.01]) as compared to women (HR 0.85 [0.5; 1.45]). This large multicentre cohort study shows an association between long-term exposure to PM2.5 and gastric cancer, but not UADT cancers, suggesting that air pollution may contribute to gastric cancer risk.",

keywords = "Air pollution, Epidemiology, ESCAPE, Gastric cancer, Upper aerodigestive tract cancer, epidemiology, gastric cancer, air pollution, upper aerodigestive tract cancer",

author = "Gabriele Nagel and Massimo Stafoggia and Marie Pedersen and Andersen, {Zorana J.} and Claudia Galassi and Jule Munkenast and Andrea Jaensch and Johan Sommar and Bertil Forsberg and David Olsson and Bente Oftedal and Krog, {Norun H.} and Geir Aamodt and Andrei Pyko and G{\"o}ran Pershagen and Michal Korek and {De Faire}, Ulf and Pedersen, {Nancy L.} and {\"O}stenson, {Claes G{\"o}ran} and Laura Fratiglioni and Mette S{\o}rensen and Anne Tj{\o}nneland and Peeters, {Petra H.} and Bas Bueno-de-Mesquita and Roel Vermeulen and Marloes Eeftens and Michelle Plusquin and Key, {Timothy J.} and Hans Concin and Alois Lang and Meng Wang and Tsai, {Ming Yi} and Sara Grioni and Alessandro Marcon and Vittorio Krogh and Fulvio Ricceri and Carlotta Sacerdote and Andrea Ranzi and Giulia Cesaroni and Francesco Forastiere and Ibon Tamayo-Uria and Pilar Amiano and Miren Dorronsoro and {de Hoogh}, Kees and Rob Beelen and Paolo Vineis and Bert Brunekreef and Gerard Hoek and Ole Raaschou-Nielsen and Gudrun Weinmayr",

year = "2018",

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doi = "10.1002/ijc.31564",

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volume = "143",

pages = "1632--1643",

journal = "International Journal of Cancer",

issn = "0020-7136",

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Nagel, G, Stafoggia, M, Pedersen, M, Andersen, ZJ, Galassi, C, Munkenast, J, Jaensch, A, Sommar, J, Forsberg, B, Olsson, D, Oftedal, B, Krog, NH, Aamodt, G, Pyko, A, Pershagen, G, Korek, M, De Faire, U, Pedersen, NL, Östenson, CG, Fratiglioni, L, Sørensen, M, Tjønneland, A, Peeters, PH, Bueno-de-Mesquita, B, Vermeulen, R, Eeftens, M, Plusquin, M, Key, TJ, Concin, H, Lang, A, Wang, M, Tsai, MY, Grioni, S, Marcon, A, Krogh, V, Ricceri, F, Sacerdote, C, Ranzi, A, Cesaroni, G, Forastiere, F, Tamayo-Uria, I, Amiano, P, Dorronsoro, M, de Hoogh, K, Beelen, R, Vineis, P, Brunekreef, B, Hoek, G, Raaschou-Nielsen, O & Weinmayr, G 2018, 'Air pollution and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts for Air Pollution Effects (ESCAPE)', International Journal of Cancer, vol. 143, no. 7, pp. 1632-1643. https://doi.org/10.1002/ijc.31564

Air pollution and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts for Air Pollution Effects (ESCAPE). / Nagel, Gabriele; Stafoggia, Massimo; Pedersen, Marie et al.
In: International Journal of Cancer, Vol. 143, No. 7, 01.10.2018, p. 1632-1643.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Air pollution and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts for Air Pollution Effects (ESCAPE)

AU - Nagel, Gabriele

AU - Stafoggia, Massimo

AU - Pedersen, Marie

AU - Andersen, Zorana J.

AU - Galassi, Claudia

AU - Munkenast, Jule

AU - Jaensch, Andrea

AU - Sommar, Johan

AU - Forsberg, Bertil

AU - Olsson, David

AU - Oftedal, Bente

AU - Krog, Norun H.

AU - Aamodt, Geir

AU - Pyko, Andrei

AU - Pershagen, Göran

AU - Korek, Michal

AU - De Faire, Ulf

AU - Pedersen, Nancy L.

AU - Östenson, Claes Göran

AU - Fratiglioni, Laura

AU - Sørensen, Mette

AU - Tjønneland, Anne

AU - Peeters, Petra H.

AU - Bueno-de-Mesquita, Bas

AU - Vermeulen, Roel

AU - Eeftens, Marloes

AU - Plusquin, Michelle

AU - Key, Timothy J.

AU - Concin, Hans

AU - Lang, Alois

AU - Wang, Meng

AU - Tsai, Ming Yi

AU - Grioni, Sara

AU - Marcon, Alessandro

AU - Krogh, Vittorio

AU - Ricceri, Fulvio

AU - Sacerdote, Carlotta

AU - Ranzi, Andrea

AU - Cesaroni, Giulia

AU - Forastiere, Francesco

AU - Tamayo-Uria, Ibon

AU - Amiano, Pilar

AU - Dorronsoro, Miren

AU - de Hoogh, Kees

AU - Beelen, Rob

AU - Vineis, Paolo

AU - Brunekreef, Bert

AU - Hoek, Gerard

AU - Raaschou-Nielsen, Ole

AU - Weinmayr, Gudrun

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Air pollution has been classified as carcinogenic to humans. However, to date little is known about the relevance for cancers of the stomach and upper aerodigestive tract (UADT). We investigated the association of long-term exposure to ambient air pollution with incidence of gastric and UADT cancer in 11 European cohorts. Air pollution exposure was assigned by land-use regression models for particulate matter (PM) below 10 μm (PM10), below 2.5 μm (PM2.5), between 2.5 and 10 μm (PMcoarse), PM2.5 absorbance and nitrogen oxides (NO2 and NOX) as well as approximated by traffic indicators. Cox regression models with adjustment for potential confounders were used for cohort-specific analyses. Combined estimates were determined with random effects meta-analyses. During average follow-up of 14.1 years of 305,551 individuals, 744 incident cases of gastric cancer and 933 of UADT cancer occurred. The hazard ratio for an increase of 5 μg/m3 of PM2.5 was 1.38 (95% CI 0.99; 1.92) for gastric and 1.05 (95% CI 0.62; 1.77) for UADT cancers. No associations were found for any of the other exposures considered. Adjustment for additional confounders and restriction to study participants with stable addresses did not influence markedly the effect estimate for PM2.5 and gastric cancer. Higher estimated risks of gastric cancer associated with PM2.5 was found in men (HR 1.98 [1.30; 3.01]) as compared to women (HR 0.85 [0.5; 1.45]). This large multicentre cohort study shows an association between long-term exposure to PM2.5 and gastric cancer, but not UADT cancers, suggesting that air pollution may contribute to gastric cancer risk.

AB - Air pollution has been classified as carcinogenic to humans. However, to date little is known about the relevance for cancers of the stomach and upper aerodigestive tract (UADT). We investigated the association of long-term exposure to ambient air pollution with incidence of gastric and UADT cancer in 11 European cohorts. Air pollution exposure was assigned by land-use regression models for particulate matter (PM) below 10 μm (PM10), below 2.5 μm (PM2.5), between 2.5 and 10 μm (PMcoarse), PM2.5 absorbance and nitrogen oxides (NO2 and NOX) as well as approximated by traffic indicators. Cox regression models with adjustment for potential confounders were used for cohort-specific analyses. Combined estimates were determined with random effects meta-analyses. During average follow-up of 14.1 years of 305,551 individuals, 744 incident cases of gastric cancer and 933 of UADT cancer occurred. The hazard ratio for an increase of 5 μg/m3 of PM2.5 was 1.38 (95% CI 0.99; 1.92) for gastric and 1.05 (95% CI 0.62; 1.77) for UADT cancers. No associations were found for any of the other exposures considered. Adjustment for additional confounders and restriction to study participants with stable addresses did not influence markedly the effect estimate for PM2.5 and gastric cancer. Higher estimated risks of gastric cancer associated with PM2.5 was found in men (HR 1.98 [1.30; 3.01]) as compared to women (HR 0.85 [0.5; 1.45]). This large multicentre cohort study shows an association between long-term exposure to PM2.5 and gastric cancer, but not UADT cancers, suggesting that air pollution may contribute to gastric cancer risk.

KW - Air pollution

KW - Epidemiology

KW - ESCAPE

KW - Gastric cancer

KW - Upper aerodigestive tract cancer

KW - epidemiology

KW - gastric cancer

KW - air pollution

KW - upper aerodigestive tract cancer

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U2 - 10.1002/ijc.31564

DO - 10.1002/ijc.31564

M3 - Article

AN - SCOPUS:85050601553

SN - 0020-7136

VL - 143

SP - 1632

EP - 1643

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 7

ER -

Air pollution and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts for Air Pollution Effects (ESCAPE)

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